Wei Wen,Gina G Turrigiano
Wei Wen
To perform computations with the efficiency necessary for animal survival, neocortical microcircuits must be capable of reconfiguring in response to experience, while carefully regulating excitatory and inhibitory connectivity to maintain s...
Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain [0.03%]
听觉分子管弦乐中的和谐：从耳朵到大脑的发育机制
Sonja J Pyott,Gabriela Pavlinkova,Ebenezer N Yamoah et al.
Sonja J Pyott et al.
Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary a...
Michael Arcaro,Margaret Livingstone
Michael Arcaro
It is a common view that the intricate array of specialized domains in the ventral visual pathway is innately prespecified. What this review postulates is that they are not. We explore the origins of domain specificity, hypothesizing that t...
How Do You Build a Cognitive Map? The Development of Circuits and Computations for the Representation of Space in the Brain [0.03%]
大脑如何构建认知地图？脑内空间表征电路和计算的发展规律
Flavio Donato,Anja Xu Schwartzlose,Renan Augusto Viana Mendes
Flavio Donato
In mammals, the activity of neurons in the entorhinal-hippocampal network is modulated by the animal's position and its movement through space. At multiple stages of this distributed circuit, distinct populations of neurons can represent a ...
Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain [0.03%]
通过将大脑中的胶质细胞转化为神经元来抑制PTB的治疗潜力
Xiang-Dong Fu,William C Mobley
Xiang-Dong Fu
Cell replacement therapy represents a promising approach for treating neurodegenerative diseases. Contrary to the common addition strategy to generate new neurons from glia by overexpressing a lineage-specific transcription factor(s), a rec...
Gesine Saher
Gesine Saher
All mammalian cell membranes contain cholesterol to maintain membrane integrity. The transport of this hydrophobic lipid is mediated by lipoproteins. Cholesterol is especially enriched in the brain, particularly in synaptic and myelin membr...
How Flies See Motion [0.03%]
苍蝇如何看见动态物体
Alexander Borst,Lukas N Groschner
Alexander Borst
How neurons detect the direction of motion is a prime example of neural computation: Motion vision is found in the visual systems of virtually all sighted animals, it is important for survival, and it requires interesting computations with ...
Rachel I Wilson
Rachel I Wilson
Many animals can navigate toward a goal they cannot see based on an internal representation of that goal in the brain's spatial maps. These maps are organized around networks with stable fixed-point dynamics (attractors), anchored to landma...
Ben Deen,Caspar M Schwiedrzik,Julia Sliwa et al.
Ben Deen et al.
Primates have evolved diverse cognitive capabilities to navigate their complex social world. To understand how the brain implements critical social cognitive abilities, we describe functional specialization in the domains of face processing...
Cortical Integration of Vestibular and Visual Cues for Navigation, Visual Processing, and Perception [0.03%]
头动依赖的视皮层整合及其在导航、视觉处理和感知中的作用
Sepiedeh Keshavarzi,Mateo Velez-Fort,Troy W Margrie
Sepiedeh Keshavarzi
Despite increasing evidence of its involvement in several key functions of the cerebral cortex, the vestibular sense rarely enters our consciousness. Indeed, the extent to which these internal signals are incorporated within cortical sensor...