Benjamin L L Clayton,Shane A Liddelow
Benjamin L L Clayton
Astrocytes, the bushy, star-shaped glial cells of the brain and spinal cord, support the proper development and function of many cells in the central nervous system. In response to disease or injury they transform, adopting varied morpholog...
Marilyn R Steyert,Tao Li,Xianhua Piao et al.
Marilyn R Steyert et al.
The cerebral cortex, a brain structure that is responsible for higher-order cognitive functions, contains hundreds of distinct cell types distributed across dozens of anatomical and functional areas. These cells emerge from a limited set of...
Shigeki Watanabe
Shigeki Watanabe
The mechanisms underlying synaptic vesicle endocytosis remain controversial. In the 1970s, Heuser and Reese put forward a hypothesis that clathrin-mediated endocytosis is the predominant vesicle retrieval mechanism. In their seminal papers,...
From Organoids to Assembloids: Experimental Approaches to Study Human Neuropsychiatric Disorders [0.03%]
从类器官到组装体：研究人类神经精神疾病的实验方法
Rebecca J Levy,Sergiu P Paşca
Rebecca J Levy
To understand the pathophysiology and develop effective therapeutics for brain disorders, some of which may involve uniquely human features of the nervous system, scalable human models of neural cell diversity and circuit formation are esse...
Caroline Haimerl,Filipe S Rodrigues,Joseph J Paton
Caroline Haimerl
Because organisms are able to sense its passage, it is perhaps tempting to treat time as a sensory modality, akin to vision or audition. Indeed, certain features of sensory estimation, such as Weber's law, apply to timing and sensation alik...
JoAnn Buchanan,Lucas Cheadle
JoAnn Buchanan
Oligodendrocyte precursor cells (OPCs) are glia that give rise to myelinating oligodendrocytes in the developing and adult brain. However, emerging data suggest that OPCs perform a wide range of functions beyond oligodendrogenesis. For exam...
Carina Curto,Nicole Sanderson
Carina Curto
We review recent developments of the use of topology in neuroscience. From grid cells and head direction cells to the geometry of olfactory space, modern applied topology methods such as persistent homology are increasingly being used to st...
Martyn Goulding,Tejapratap Bollu,Ansgar Büschges
Martyn Goulding
Motor systems in animals are highly dependent on sensory information for optimal control and precision, with mechanosensory feedback from the somatosensory system playing a critical role. These mechanosensory pathways are woven into the des...
Maria Sachkova,Vengamanaidu Modepalli,Maike Kittelmann
Maria Sachkova
The evolutionary success of animals can, at least in part, be attributed to the presence of neurons that allow long-distance communication between tissues, coordination of movements, and the capacity for learning. However, the evolutionary ...
Lucas Encarnacion-Rivera,Karl Deisseroth,Liqun Luo
Lucas Encarnacion-Rivera
Thirst and hunger drives are fundamental survival mechanisms that transform physiological need into motivated behavior. In the brain, discrete types of circumventricular and hypothalamic neurons serve as neural circuit elements underlying t...