Anesthetics as Treatments for Depression: Clinical Insights and Underlying Mechanisms [0.03%]
麻醉剂作为治疗抑郁的药物：临床见解和潜在机制
Macauley Smith Breault,Sirma Orguc,Ohyoon Kwon et al.
Macauley Smith Breault et al.
Major depressive disorder and treatment-resistant depression are significant worldwide health problems that need new therapies. The success of the anesthetic ketamine as an antidepressant is well known. It is less widely known that several ...
Jinbo Zhang,Jianxin Ou,Yunzhe Liu
Jinbo Zhang
During rest and sleep, the brain processes information through replay, reactivating neural patterns linked to past events and facilitating the exploration of potential future scenarios. This review summarizes recent advances in understandin...
Karrie M Kiang,Yogesh K H Wong,Soma Sengupta et al.
Karrie M Kiang et al.
Medulloblastoma is the most common pediatric brain cancer and is broadly categorized into four molecular subgroups. Understanding the cell origins of medulloblastoma is crucial for preventing tumor formation and relapse. Recent single-cell ...
Laurence Picton,Irene Pallucchi,Pierre Fontanel et al.
Laurence Picton et al.
Locomotion, like all behaviors, possesses an inherent flexibility that allows for the scaling of movement kinematic features, such as speed and vigor, in response to an ever-changing external world and internal drives. This flexibility is e...
Michael J Frank
Michael J Frank
The twenty-first century has brought forth a deluge of theories and data shedding light on the neural mechanisms of motivated behavior. Much of this progress has focused on dopaminergic dynamics, including their signaling properties (how do...
Cortical Layer-Dependent Signaling in Cognition: Three Computational Modes of the Canonical Circuit [0.03%]
皮层层级依赖的认知信号：经典环路的三种计算模式
Yasushi Miyashita
Yasushi Miyashita
The cerebral cortex performs computations via numerous six-layer modules. The operational dynamics of these modules were studied primarily in early sensory cortices using bottom-up computation for response selectivity as a model, which has ...
Samuel K Asinof,Gwyneth M Card
Samuel K Asinof
In the natural world, animals make decisions on an ongoing basis, continuously selecting which action to undertake next. In the lab, however, the neural bases of decision processes have mostly been studied using artificial trial structures....
Ling L Dong,Ila R Fiete
Ling L Dong
The activity patterns of grid cells form distinctively regular triangular lattices over the explored spatial environment and are largely invariant to visual stimuli, animal movement, and environment geometry. These neurons present numerous ...
Greta Tuckute,Nancy Kanwisher,Evelina Fedorenko
Greta Tuckute
It has long been argued that only humans could produce and understand language. But now, for the first time, artificial language models (LMs) achieve this feat. Here we survey the new purchase LMs are providing on the question of how langua...
Herwig Baier,Ethan K Scott
Herwig Baier
The zebrafish visual system has become a paradigmatic preparation for behavioral and systems neuroscience. Around 40 types of retinal ganglion cells (RGCs) serve as matched filters for stimulus features, including light, optic flow, prey, a...