Prenatal Immune Stress: Its Impact on Brain Development and Neuropsychiatric Disorders [0.03%]
孕期免疫应激对脑发育及神经精神疾病的影响
Navneet A Vasistha,Akira Sawa
Navneet A Vasistha
Many epidemiological studies have indicated that prenatal immune stress, frequently elicited by maternal immune activation, underlies a major risk for neuropsychiatric disorders of neurodevelopmental origin, such as schizophrenia and autism...
John O&#x;Keefe
John O&#x;Keefe
During navigation to a goal, a portion of the hippocampal place cells exhibit directional preferences, firing more in some directions than in others. These directional preferences create vector fields oriented toward locations scattered aro...
Cell Type-Specific Studies of Human Tissue for Investigation of the Molecular Cell Biology of Late-Onset Neurodegenerative Disease [0.03%]
关于人类组织的特化细胞类型的研究以探讨晚发神经退行性疾病的分子细胞生物学特性
Kert Mätlik,Christina Pressl,Nathaniel Heintz
Kert Mätlik
Decades of research into human neurodegenerative diseases have revealed important similarities as well as dissimilarities between diseases. While investigations of specific mechanistic aspects of diseases have been aided by cell and animal ...
Astrocytes as Key Regulators of Neural Signaling in Health and Disease [0.03%]
星形胶质细胞作为健康和疾病中神经信号的关键调节者
Woojin Won,Mridula Bhalla,Jae-Hun Lee et al.
Woojin Won et al.
Astrocytes, traditionally viewed as supportive cells within the central nervous system (CNS), are now recognized as dynamic regulators of neural signaling and homeostasis. They actively engage in synaptic transmission and brain health by re...
Non-Image-Forming Functions of Intrinsically Photosensitive Retinal Ganglion Cells [0.03%]
内在光敏感性视网膜神经节细胞的非图像形成功能
Jianjun Meng,Xiaodan Huang,Chaoran Ren et al.
Jianjun Meng et al.
Life on this planet is heavily influenced by light, the most critical external environmental factor. Mammals perceive environmental light mainly through three types of photoreceptors in the retina-rods, cones, and intrinsically photosensiti...
Meital Oren-Suissa,Troy R Shirangi
Meital Oren-Suissa
Sexually dimorphic instinctual behaviors that set females and males apart are found across animal clades. Recent studies in a variety of animal systems have provided deep insights into the neural circuits that guide sexually dimorphic behav...
Dimitra Vardalaki,Courtney E Yaeger,Mark T Harnett
Dimitra Vardalaki
The formation of new synapses, the connections between neurons, is the critical step for neural circuit assembly. Newly formed glutamatergic synapses are initially silent and require activity-dependent plasticity to become fully functional ...
Phase Separation-Mediated Compartmentalization Underlies Synapse Formation and Plasticity [0.03%]
相分离介导的分隔是突触形成及可塑性的基础
Xiandeng Wu,Zeyu Shen,Mingjie Zhang
Xiandeng Wu
The synapse is polarized and highly compartmentalized on both its pre- and postsynaptic sides. The compartmentalization of synaptic vesicles, as well as vesicle releasing and recycling machineries, allows neurotransmitters to be released wi...
Oluwadamilola O Lawal,Dayu Lin,Julieta E Lischinsky
Oluwadamilola O Lawal
Social behaviors, including parental care, mating, and fighting, all depend on the hormonal milieu of an organism. Decades of work highlighted estrogen as a key hormonal controller of social behaviors, exerting its influence primarily throu...
Anesthetics as Treatments for Depression: Clinical Insights and Underlying Mechanisms [0.03%]
麻醉剂作为治疗抑郁的药物：临床见解和潜在机制
Macauley Smith Breault,Sirma Orguc,Ohyoon Kwon et al.
Macauley Smith Breault et al.
Major depressive disorder and treatment-resistant depression are significant worldwide health problems that need new therapies. The success of the anesthetic ketamine as an antidepressant is well known. It is less widely known that several ...