Abena K Kwaa,Joel N Blankson
Abena K Kwaa
Elite controllers are a heterogeneous group of people living with HIV who control viral replication without antiretroviral therapy. There is substantial evidence that at least some elite controllers are infected with replication-competent v...
Arthur Weiss
Arthur Weiss
I have spent more than the last 40 years at the University of California, San Francisco (UCSF), studying T cell receptor (TCR) signaling. I was blessed with supportive mentors, an exceptionally talented group of trainees, and wonderful coll...
Dali Han,Meng Michelle Xu
Dali Han
Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In th...
Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils [0.03%]
组织髓系细胞的起源和异质性：关于GMP衍生的单核细胞和中性粒细胞的关注点
Lai Guan Ng,Zhaoyuan Liu,Immanuel Kwok et al.
Lai Guan Ng et al.
Myeloid cells are a significant proportion of leukocytes within tissues, comprising granulocytes, monocytes, dendritic cells, and macrophages. With the identification of various myeloid cells that perform separate but complementary function...
Modeling T Cell Fate [0.03%]
T细胞命运决定的模型研究
Rob J De Boer,Andrew J Yates
Rob J De Boer
Many of the pathways that underlie the diversification of naive T cells into effector and memory subsets, and the maintenance of these populations, remain controversial. In recent years a variety of experimental tools have been developed th...
Denis A Mogilenko,Alexey Sergushichev,Maxim N Artyomov
Denis A Mogilenko
Over the last decade, immunometabolism has emerged as a novel interdisciplinary field of research and yielded significant fundamental insights into the regulation of immune responses. Multiple classical approaches to interrogate immunometab...
Interfering with Interferons: A Critical Mechanism for Critical COVID-19 Pneumonia [0.03%]
干扰干扰素：Critical COVID-19肺炎的关键机制
Helen C Su,Huie Jing,Yu Zhang et al.
Helen C Su et al.
Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign infection in most individuals to critical pneumonia and death in a few. Genetic studies in patients have established that critical cases can result from in...
Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging [0.03%]
高度分化的T细胞亚群在衰老过程中导致组织损伤
Gonzalo Soto-Heredero,Manuel M Gómez de Las Heras,J Ignacio Escrig-Larena et al.
Gonzalo Soto-Heredero et al.
There is a dramatic remodeling of the T cell compartment during aging. The most notorious changes are the reduction of the naive T cell pool and the accumulation of memory-like T cells. Memory-like T cells in older people acquire a phenotyp...
Not Dead Yet [0.03%]
还活着
Betty Diamond
Betty Diamond
I have been a scientific grasshopper throughout my career, moving from question to question within the domain of lupus. This has proven to be immensely gratifying. Scientific exploration is endlessly fascinating, and succeeding in studies y...
Simone Caielli,Zurong Wan,Virginia Pascual
Simone Caielli
Autoreactive B cells and interferons are central players in systemic lupus erythematosus (SLE) pathogenesis. The partial success of drugs targeting these pathways, however, supports heterogeneity in upstream mechanisms contributing to disea...