CD8+ Regulatory T Cells [0.03%]
CD8⁺ 调节性T细胞
Veena K Vuttaradhi,Clotilde M Vermelle,John Y Choi et al.
Veena K Vuttaradhi et al.
A wide variety of suppressive pathways have been investigated in efforts to understand the basis for immune tolerance. Although the contribution of CD4+ regulatory T cells (Tregs) to self-tolerance has been extensively studied, less attenti...
Harnessing the Microbiome in Cancer Immunotherapy: Regulation, Prediction, and Therapeutic Targeting [0.03%]
肿瘤免疫治疗中微生物组的应用：调节、预测及靶点探索
Hassane M Zarour,Giorgio Trinchieri
Hassane M Zarour
Humans are metaorganisms, composed of both host (human) cells and a roughly equal number of commensal microorganisms-collectively known as the microbiome-residing primarily at epithelial barrier surfaces. This review considers human cancer ...
Tada Taniguchi
Tada Taniguchi
"I appeared as a dewdrop, and disappearing as it is. All of my beloved Naniwa (Osaka) is just a dream of dreams." This quote is the funeral ode of Hideyoshi Toyotomi, who is regarded as a "Great Unifier of Japan" for his role before the Tok...
Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases [0.03%]
细胞死亡的遗传调节：自身炎症性疾病的启示
Hirotsugu Oda,Alessandro Annibaldi,Daniel L Kastner et al.
Hirotsugu Oda et al.
Metazoans have evolved innate antimicrobial defenses that promote cellular survival and proliferation. Countering the inevitable molecular mechanisms by which microbes sabotage these pathways, multicellular organisms rely on an alternative,...
Devesha H Kulkarni,Rodney D Newberry
Devesha H Kulkarni
The mammalian gut is a vast, diverse, and dynamic single-layer epithelial surface exposed to trillions of microbes, microbial products, and the diet. Underlying this epithelium lies the largest collection of immune cells in the body; these ...
Bidirectional Communication Between the Innate and Adaptive Immune Systems [0.03%]
先天免疫系统与适应性免疫系统的双向交流
Kathrynne A Warrick,Charles N Vallez,Hannah E Meibers et al.
Kathrynne A Warrick et al.
Effective bidirectional communication between the innate and adaptive immune systems is crucial for tissue homeostasis and protective immunity against infections. The innate immune system is responsible for the early sensing of and initial ...
Musa M Mhlanga,Stephanie Fanucchi,Mumin Ozturk et al.
Musa M Mhlanga et al.
There has been an increasing effort to understand the memory responses of a complex interplay among innate, adaptive, and structural cells in peripheral organs and bone marrow. Trained immunity is coined as the de facto memory of innate imm...
Linda V Sinclair,Doreen A Cantrell
Linda V Sinclair
T lymphocytes are essential for immune responses to pathogens and tumors. Their ability to rapidly clonally expand and differentiate to effector cells following infection, and then to curb effector function following infection clearance, is...
Human Immune Responses to Epstein-Barr Virus Highlighted by Immunodeficiencies [0.03%]
免疫缺陷突出的EB病毒的人体免疫反应
Sylvain Latour
Sylvain Latour
Inborn errors of immunity (IEIs) represent unique in natura models that uncover key components of immunity in humans, in particular those that predispose to infections. Epstein-Barr virus (EBV) is one of the most common opportunistic infect...
Molecular Mechanisms Governing CD8 T Cell Differentiation and Checkpoint Inhibitor Response in Cancer [0.03%]
癌症中CD8 T细胞分化和检查点抑制反应的分子机制
Lisa Rausch,Axel Kallies
Lisa Rausch
CD8 T cells play a critical role in antitumor immunity. However, over time, they often become dysfunctional or exhausted and ultimately fail to control tumor growth. To effectively harness CD8 T cells for cancer immunotherapy, a detailed un...