T Cell Receptor Signaling and Immune Tolerance: From Autoimmunity to Cancer Immunity [0.03%]
T细胞受体信号转导和免疫耐受：从自身免疫到肿瘤免疫
Atsushi Tanaka,Shimon Sakaguchi
Atsushi Tanaka
The intensity of T cell receptor (TCR) signaling controls thymic positive and negative selection of conventional T cells (Tconv cells) and regulatory T cells (Treg cells), as well as their peripheral activation. Accordingly, the effects of ...
γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight [0.03%]
伽玛德尔塔T细胞在癌症免疫治疗中的作用：非传统玩家成为焦点
Georgia Stevens,Rafael Blanco-Domínguez,Sofia Mensurado et al.
Georgia Stevens et al.
The success of cancer immunotherapy depends on the mobilization of leukocytes with the capacity to eliminate tumor cells. γδ T cells represent a lymphocyte lineage with strong cytotoxic potential and abundant production of antitumor cytok...
Zhibin Zhang,Judy Lieberman
Zhibin Zhang
The major effector cells of antitumor immunity are killer lymphocytes that recognize and eliminate tumor cells. The fact that tumor cells look a lot like normal cells poses a challenge to antitumor immune control. A danger signal from the t...
B Cell Selection in Antibody Production: Affinity Rules, but Diversity Matters [0.03%]
抗体产生中的B细胞选择：亲和力准则，但多样性亦重要
Isaak Quast,David M Tarlinton
Isaak Quast
Affinity for antigen is a fundamental parameter of humoral immunity. It determines the B cell clones that participate in the response, it is a readout of clonal selection as the response progresses, and the magnitude of its improvement in T...
Targeting Inhibitory Immune Receptors in Inflammatory Disease, Guided by Molecular Understanding of Their Function [0.03%]
基于分子功能的炎症性疾病抑制性免疫受体的靶向治疗
Linde Meyaard,Michiel van der Vlist
Linde Meyaard
Immune inhibitory receptors are negative regulators of immune cells and, as such, dampen immune responses. Blocking inhibitory receptors in cancer results in not only powerful antitumor responses but also a diverse array of immune-related a...
Xuanming Guo,Scott J Russo
Xuanming Guo
Here we introduce the Cross-Organ Neuroimmunology of Behavior (CONB) Network, a framework that reconceptualizes behavior as an emergent property of a distributed, whole-body immune-brain network. It builds on knowledge of neuroimmune commun...
Gabriel A Rabinovich,Christoph Rademacher,Mirta Schattner et al.
Gabriel A Rabinovich et al.
Glycan-binding proteins (GBPs), including Galectins, sialic acid-binding immunoglobin-type lectins (Siglecs), and C-type lectin receptors (CLRs), are key regulators of immune cell development, activation, differentiation, trafficking, and h...
Pierre-Vincent Barbon,Guillaume Hoeffel,Tiphaine Fohrer et al.
Pierre-Vincent Barbon et al.
The exploration of neuroimmune interactions at tissue barriers has become pivotal for our understanding of how organisms survive and adapt to challenging environments. Serving both as a physical barrier and a sensory organ, the skin has evo...
Tissue Regulatory T Cells [0.03%]
组织调节性T细胞
Markus Feuerer,Daniel H D Gray,Lucille C Rankin et al.
Markus Feuerer et al.
FOXP3+ regulatory T cells (Tregs) have well-defined roles in limiting systemic immune responses against diverse stimuli. However, the observation that a subset of Tregs also enter nonlymphoid tissues, where they assume additional functions,...
Charles A P Sweeney,Hanyu Liu,Matthew Dean et al.
Charles A P Sweeney et al.
Focusing on adipose tissue function, this review examines the neuroimmune mechanisms by which sympathetic neurons regulate body weight. Under healthy conditions, anti-inflammatory cues from perineurial barrier cells, mesenchymal cells, and ...