Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases [0.03%]
细胞死亡的遗传调节：自身炎症性疾病的启示
Hirotsugu Oda,Alessandro Annibaldi,Daniel L Kastner et al.
Hirotsugu Oda et al.
Metazoans have evolved innate antimicrobial defenses that promote cellular survival and proliferation. Countering the inevitable molecular mechanisms by which microbes sabotage these pathways, multicellular organisms rely on an alternative,...
Devesha H Kulkarni,Rodney D Newberry
Devesha H Kulkarni
The mammalian gut is a vast, diverse, and dynamic single-layer epithelial surface exposed to trillions of microbes, microbial products, and the diet. Underlying this epithelium lies the largest collection of immune cells in the body; these ...
Bidirectional Communication Between the Innate and Adaptive Immune Systems [0.03%]
先天免疫系统与适应性免疫系统的双向交流
Kathrynne A Warrick,Charles N Vallez,Hannah E Meibers et al.
Kathrynne A Warrick et al.
Effective bidirectional communication between the innate and adaptive immune systems is crucial for tissue homeostasis and protective immunity against infections. The innate immune system is responsible for the early sensing of and initial ...
Musa M Mhlanga,Stephanie Fanucchi,Mumin Ozturk et al.
Musa M Mhlanga et al.
There has been an increasing effort to understand the memory responses of a complex interplay among innate, adaptive, and structural cells in peripheral organs and bone marrow. Trained immunity is coined as the de facto memory of innate imm...
Linda V Sinclair,Doreen A Cantrell
Linda V Sinclair
T lymphocytes are essential for immune responses to pathogens and tumors. Their ability to rapidly clonally expand and differentiate to effector cells following infection, and then to curb effector function following infection clearance, is...
Human Immune Responses to Epstein-Barr Virus Highlighted by Immunodeficiencies [0.03%]
免疫缺陷突出的EB病毒的人体免疫反应
Sylvain Latour
Sylvain Latour
Inborn errors of immunity (IEIs) represent unique in natura models that uncover key components of immunity in humans, in particular those that predispose to infections. Epstein-Barr virus (EBV) is one of the most common opportunistic infect...
Molecular Mechanisms Governing CD8 T Cell Differentiation and Checkpoint Inhibitor Response in Cancer [0.03%]
癌症中CD8 T细胞分化和检查点抑制反应的分子机制
Lisa Rausch,Axel Kallies
Lisa Rausch
CD8 T cells play a critical role in antitumor immunity. However, over time, they often become dysfunctional or exhausted and ultimately fail to control tumor growth. To effectively harness CD8 T cells for cancer immunotherapy, a detailed un...
Barrier Integrity and Immunity: Exploring the Cutaneous Front Line in Health and Disease [0.03%]
屏障完整性和免疫性：探索健康与疾病下的皮肤前线
Keitaro Fukuda,Yoshihiro Ito,Masayuki Amagai
Keitaro Fukuda
Immune responses are influenced by not only immune cells but also the tissue microenvironment where these cells reside. Recent advancements in understanding the underlying molecular mechanisms and structures of the epidermal tight junctions...
Humanized Mouse Systems to Study Viral Infection: A New Era in Immunology Research [0.03%]
人源化小鼠系统在病毒感染研究中的应用：免疫学研究的新时代
Angela Wahl,J Victor Garcia
Angela Wahl
For decades, scientists have relied on traditional animal models to study viral infection and the immune response. However, these models have limitations, and the search for more accurate and reliable ways to study the human-pathogen interp...
From Cytokines to Tuberculosis and Back: My Journey to Understanding the Immune Response to Infection [0.03%]
从细胞因子到结核病再回到免疫反应：我研究感染免疫应答的历程
Anne O&#x;Garra
Anne O&#x;Garra
I felt honored by the invitation to write this autobiography, although it was an arduous task to describe my journey through science: first bacterial adhesion, then cytokine function, and then immune responses in tuberculosis. Since only se...