The Neuroimmune Circuitry of Peripheral Sensory Neuron Subtypes in Chronic Pain [0.03%]
慢性疼痛外周感觉神经元亚型的神经免疫回路
Hyo Jeong Yong,William Renthal
Hyo Jeong Yong
Peripheral sensory neurons, long appreciated for their role in detecting environmental stimuli, also play an active role in local and systemic immune responses. In response to tissue damage, the coordinated activation of peripheral sensory ...
Alberto Guarnieri,Shannon J Turley
Alberto Guarnieri
Recent advancements in single-cell omic technology and lineage-tracing approaches have established that functional and dysfunctional activities of the immune system are critically influenced by context-specific microenvironmental factors. A...
The Molecular Logic of Immunoglobulin Heavy Chain Class Switch Recombination [0.03%]
免疫球蛋白重链类别转换重组的分子逻辑
William T Yewdell,Keith Conrad Fernandez,Stephanie M Downs-Canner et al.
William T Yewdell et al.
Class switch recombination (CSR) enables B cells to diversify antibody effector functions while preserving antigen specificity. This process involves activation-induced cytidine deaminase (AID)-mediated DNA lesions within transcribed donor ...
Decoding Human T Cell Immunity with Artificial Intelligence and Single-Cell Genomics [0.03%]
用人工智能和单细胞组学技术解读人类T细胞免疫功能
Lisa M Dratva,Sarah A Teichmann,Lorenz Kretschmer
Lisa M Dratva
T cells are key mediators of adaptive immunity, yet their highly dynamic response states and immense T cell receptor (TCR) diversity pose challenges in deciphering their functional roles in human diseases. Recent advances in single-cell gen...
Immune Niches in Cancer [0.03%]
癌症免疫生态龛
Nadine Slingerland,Eline Runderkamp,Daniela S Thommen
Nadine Slingerland
Emerging evidence underscores a key role for the tumor microenvironment in supporting or suppressing cancer immunity. Of note, pro- and antitumor immune activity is controlled by not only the types of immune cells present but also their spa...
T Cell Receptor Signaling and Immune Tolerance: From Autoimmunity to Cancer Immunity [0.03%]
T细胞受体信号转导和免疫耐受：从自身免疫到肿瘤免疫
Atsushi Tanaka,Shimon Sakaguchi
Atsushi Tanaka
The intensity of T cell receptor (TCR) signaling controls thymic positive and negative selection of conventional T cells (Tconv cells) and regulatory T cells (Treg cells), as well as their peripheral activation. Accordingly, the effects of ...
γδ T Cells for Cancer Immunotherapy: Unconventional Players Take the Spotlight [0.03%]
伽玛德尔塔T细胞在癌症免疫治疗中的作用：非传统玩家成为焦点
Georgia Stevens,Rafael Blanco-Domínguez,Sofia Mensurado et al.
Georgia Stevens et al.
The success of cancer immunotherapy depends on the mobilization of leukocytes with the capacity to eliminate tumor cells. γδ T cells represent a lymphocyte lineage with strong cytotoxic potential and abundant production of antitumor cytok...
Zhibin Zhang,Judy Lieberman
Zhibin Zhang
The major effector cells of antitumor immunity are killer lymphocytes that recognize and eliminate tumor cells. The fact that tumor cells look a lot like normal cells poses a challenge to antitumor immune control. A danger signal from the t...
B Cell Selection in Antibody Production: Affinity Rules, but Diversity Matters [0.03%]
抗体产生中的B细胞选择：亲和力准则，但多样性亦重要
Isaak Quast,David M Tarlinton
Isaak Quast
Affinity for antigen is a fundamental parameter of humoral immunity. It determines the B cell clones that participate in the response, it is a readout of clonal selection as the response progresses, and the magnitude of its improvement in T...
Targeting Inhibitory Immune Receptors in Inflammatory Disease, Guided by Molecular Understanding of Their Function [0.03%]
基于分子功能的炎症性疾病抑制性免疫受体的靶向治疗
Linde Meyaard,Michiel van der Vlist
Linde Meyaard
Immune inhibitory receptors are negative regulators of immune cells and, as such, dampen immune responses. Blocking inhibitory receptors in cancer results in not only powerful antitumor responses but also a diverse array of immune-related a...