J P Thornhill,M Gandhi,C Orkin
J P Thornhill
Mpox, previously known as monkeypox, is caused by an Orthopoxvirus related to the variola virus that causes smallpox. Prior to 2022, mpox was considered a zoonotic disease endemic to central and west Africa. Since May 2022, more than 86,000...
Blessie Elizabeth Nelson,Funda Meric-Bernstam
Blessie Elizabeth Nelson
Antibody-drug conjugates (ADCs) have become the cornerstone of effective therapeutics in solid and hematological malignancies by harnessing potent cytotoxic payloads with targeted tumoricidal delivery. Since the monumental shift occurred wi...
Nikhilesh R Mazumder,Robert J Fontana
Nikhilesh R Mazumder
The MELD (model for end-stage liver disease) 3.0 score was developed to replace the MELD-Na score that is currently used to prioritize liver allocation for cirrhotic patients awaiting liver transplantation in the United States. The MELD 3.0...
Carlos F Gould,Sam Heft-Neal,Mary Johnson et al.
Carlos F Gould et al.
We review current knowledge on the trends and drivers of global wildfire activity, advances in the measurement of wildfire smoke exposure, and evidence on the health effects of this exposure. We describe methodological issues in estimating ...
Lucas Lauder,Felix Mahfoud,Michael Böhm
Lucas Lauder
Resistant hypertension (RH) is a severe form of hypertension associated with increased cardiovascular risk. Although true RH affects less than 10% of the patients receiving antihypertensive therapy, the absolute number is high and continues...
Antonio C Bianco
Antonio C Bianco
Levothyroxine (LT4) is effective for most patients with hypothyroidism. However, a minority of the patients remain symptomatic despite the normalization of serum thyrotropin levels. Randomized clinical trials including all types of patients...
Carmen E Guerra,Prateek V Sharma,Brenda S Castillo
Carmen E Guerra
The new generation of cancer early detection tests holds remarkable promise for revolutionizing and changing the paradigm of cancer early detection. Dozens of cancer early detection tests are being developed and evaluated. Some are already ...
Tuyet-Trinh Truong,Albert L Siu
Tuyet-Trinh Truong
Hospital at Home (HaH) provides hospital-level services in the home to eligible patients who would otherwise require facility-based hospitalization. In the last two decades, studies have shown that HaH can improve patient outcomes and satis...
Wade Thompson,Emily G McDonald
Wade Thompson
Older adults commonly end up on many medications. Deprescribing is an important part of individualizing care for older adults. It is an opportunity to discuss treatment options and revisit medications that may not have been reassessed in ma...
Ji-Woon Kim,Kanzo Suzuki,Ege T Kavalali et al.
Ji-Woon Kim et al.
Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-based antidepressant drugs are a primary line of treatment for this mental disorder, although the delayed response and incomplete efficacy in some patient...