Fabian Nimczewski,Sjaak Pouwels,Jens Hoeppner
Fabian Nimczewski
Management of esophageal adenocarcinoma is moving toward personalized, multimodal approaches, with perioperative immunotherapy now a key component. Shortly before 2025, perioperative 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (F...
APOL1-Mediated Kidney Disease and the Emerging Era of Precision Therapy [0.03%]
由APOL1介导的肾脏疾病和精准治疗新时代的到来
Timothy Hopper,Bangchen Wang,Opeyemi A Olabisi
Timothy Hopper
APOL1 renal risk genetic variants (G1 and G2) account for a substantial portion of the excess burden of nondiabetic kidney disease among individuals with recent African ancestry (within the past 10,000 years). Apolipoprotein L1 (APOL1)-medi...
Dupilumab Emerges as an Effective Antibody Therapy for Eosinophilic Esophagitis [0.03%]
Dupilumab成为治疗嗜酸细胞性食管炎的有效抗体疗法
Shifali Arora,Evan S Dellon
Shifali Arora
Eosinophilic esophagitis (EoE) is a chronic allergic disease with a complex pathogenesis driven by an abnormal type 2 immune response to food or environmental allergens in the setting of impaired esophageal epithelial function. The goals of...
Amanda M Lulu,Erica Steele,Daniel W Lee
Amanda M Lulu
Having already revolutionized outcomes for relapsed or refractory B cell malignancies and multiple myeloma, chimeric antigen receptor (CAR) T cell therapy is on the cusp of significantly impacting those with solid tumors. However, antitumor...
Lawrence Zeldin,Yevgeniy Brailovsky,Mathew S Maurer
Lawrence Zeldin
Transthyretin amyloid cardiomyopathy (ATTR-CM) has emerged as a significant yet underdiagnosed cause of heart failure. Advancements in the noninvasive imaging that facilitates diagnosis at an earlier stage of disease and treatment have mark...
Accessibility of Somatic Genetic Testing for Cancer Treatment Decisions [0.03%]
癌症治疗决策中体细胞遗传检测的可及性问题分析
Madison Klavans,Fernanda B Musa,Marilyn Huang
Madison Klavans
Advances in cancer genomics have significantly influenced and improved oncologic treatments in recent years. Somatic genetic testing, which assesses for gene amplification and acquired mutations in tumor tissue, enables the identification o...
Diffuse Parenchymal Lung Disease: Updates in Pathophysiology and Management [0.03%]
弥漫性肺间质疾病的病理生理及处理近况
Jisha Joshua,Zea Borok
Jisha Joshua
Diffuse parenchymal lung disease (DPLD) is a group of distinct inflammatory-fibrotic diseases with varied causes, clinical presentations, and outcomes. Complex pathogenesis, patient heterogeneity, and nonspecificity of diagnostic techniques...
Revascularization for Ischemic Cardiomyopathy: Disproving the 45-Year-Old Concept of Hibernating Myocardium [0.03%]
缺血性心肌病的再血管化治疗：打破冬眠心肌概念僵局
Aman Kansal,Husam M Salah,Jennifer A Rymer
Aman Kansal
The understanding of myocardial ischemia evolved from early twentieth-century studies showing reversible or irreversible damage depending on ischemia duration. The concept of hibernating myocardium emerged in the 1970s, describing chronical...
Florence Porterfield,Anam Fatima,Brunna Boaventura et al.
Florence Porterfield et al.
A new era in obesity management is emerging, characterized by the development of more effective treatments and healthcare strategies. A paradigm shift in obesity care calls for a more integrated, community-based approach that bridges the ga...
Zhimin Fu,Yuxin Yang,Mina K Chung et al.
Zhimin Fu et al.
With the pharmacokinetics, dosing, safety, and manufacturing of approved or investigational drugs already well-characterized, drug repurposing and repositioning offer emerging strategies to rapidly develop effective treatments for various c...