Samantha D Minc,Katharine L McGinigle
Samantha D Minc
Peripheral artery disease (PAD) is a prevalent and underdiagnosed atherosclerotic condition affecting more than 10 million adults in the United States. PAD is a marker of systemic vascular disease and a strong predictor of myocardial infarc...
Rodrigo Paredes,S Daniel Haldar,Shubham Pant et al.
Rodrigo Paredes et al.
Cancer immunotherapy has advanced through immune checkpoint inhibitors and T cell therapies, yet challenges persist in overcoming immune evasion. Neoantigen-based vaccines have shown promise, particularly in tumors with high tumor mutation ...
Celine Yeh,Margaret C Wheless,Kristen K Ciombor et al.
Celine Yeh et al.
For decades, the management of locally advanced rectal cancer has been trimodal therapy with radiotherapy, surgery, and chemotherapy. Collectively, the adoption of total neoadjuvant therapy (TNT), advances in how radiotherapy and chemothera...
CGRP and Migraine: Real World Insights and Future Therapeutic Directions [0.03%]
降钙素基因相关肽与偏头痛：真实世界认知及未来治疗展望
Andrew F Russo,Eric A Kaiser
Andrew F Russo
Therapeutic targeting of the neuropeptide calcitonin gene-related peptide (CGRP) is a bench-to-bedside success story that has established migraine as a treatable neurological disorder. There are now eight monoclonal antibodies and small-mol...
Justin R Clark,Anthony W Maresso
Justin R Clark
Wastewater-based epidemiology (WBE) is the analysis of wastewater to detect pathogen levels or activity for public health awareness or action. Pioneered in the 1940s, WBE underwent a resurgence during the COVID-19 pandemic, providing import...
Susanne B Nicholas,Niloofar Nobakht,Radica Z Alicic
Susanne B Nicholas
Chronic kidney disease (CKD) affects 35.5 million US adults, but most patients are unaware of their diagnosis. Screening for CKD at-risk individuals is required, as symptoms do not appear until advanced stages. The combination of urine albu...
Anne Sophie Sølling,Bente L Langdahl,Felicia Cosman
Anne Sophie Sølling
Postmenopausal osteoporosis is a chronic progressive disease related to estrogen deficiency at menopause, aging, and superimposed genetic and environmental factors. Many patients with osteoporosis are not diagnosed, and the majority are not...
Regulatory T Cell Depletion in Cancer: Challenges, Opportunities, and Future Directions for Antibody Development [0.03%]
癌症中的调节性T细胞耗竭：抗体开发的挑战、机遇和未来方向
Mariela Navarrete,Cristobal Costoya,Felipe Galvez-Cancino et al.
Mariela Navarrete et al.
Regulatory T cells (Tregs) accumulate in the tumor microenvironment, where they suppress antitumor immunity and hinder immunotherapy efficacy. Antibody-mediated Treg depletion has emerged as a promising strategy, but its clinical translatio...
Lipoprotein(a): An Underappreciated Inherited Risk Factor for Atherosclerosis, Aortic Stenosis, and Abdominal Aortic Aneurysm [0.03%]
脂蛋白(a)：一种未被重视的动脉粥样硬化、主动脉瓣狭窄和腹主动脉瘤的遗传性危险因素
Marlys L Koschinsky,Dinesh K Kalra,Michael B Boffa
Marlys L Koschinsky
Elevated plasma concentration of lipoprotein(a) is a highly prevalent, independent, and causal risk factor for the development of numerous cardiovascular diseases. This review summarizes the key clinical evidence for elevated lipoprotein(a)...
Approach Toward Early Detection and Prevention of Early-Onset Colorectal Cancer [0.03%]
早期结直肠癌的早期检测和预防策略
Cassandra D L Fritz,Manju George,John M Carethers et al.
Cassandra D L Fritz et al.
Early-onset colorectal cancer (CRC), commonly defined as a CRC diagnosis before 50 years of age, is rapidly increasing. Despite overt symptoms, younger patients with early-onset CRC endure prolonged diagnostic delays. This review urgently d...