Emerging Long-Term Risks of the Use of Proton Pump Inhibitors and Potassium-Competitive Acid Blockers [0.03%]
质子泵抑制剂和钾竞争性酸阻断剂的长期应用风险不容忽视
Katarina Jankovic,Ian M Gralnek,Halim Awadie
Katarina Jankovic
Acid-related disorders represent a significant global health burden. Pharmacological treatment of these conditions has at times been challenged and limited by incomplete effectiveness, antibiotic resistance, adverse medication effects and/o...
Lara Jehi
Lara Jehi
Drug-resistant epilepsy (DRE) is defined as failure to achieve sustained seizure control with adequate trials of two appropriate antiseizure medications (ASMs). DRE affects one-third of patients with epilepsy and is associated with signific...
Sleep Health Disparities [0.03%]
睡眠健康差异性
Seyni Gueye-Ndiaye,Susan Redline
Seyni Gueye-Ndiaye
Sleep is an important and potentially modifiable determinant of many severe health outcomes. Sleep health disparities exist and are exemplified by reported differential rates of prevalence, severity, and outcomes among minority groups and l...
Kseniya Y Simbirtseva,Paul W O&#x;Toole
Kseniya Y Simbirtseva
An altered gut microbiome is a feature of many multifactorial diseases, and microbiome effects on host metabolism, immune function, and possibly neurological function are implicated. Increased biological age is accompanied by a change in th...
Transformative Therapies for Depression: Postpartum Depression, Major Depressive Disorder, and Treatment-Resistant Depression [0.03%]
变革性抗抑郁疗法：产后抑郁症、重度抑郁症和难治性抑郁症的治疗
Elizabeth Richardson,Riah Patterson,Samantha Meltzer-Brody et al.
Elizabeth Richardson et al.
Depressive disorders present an enormous global public health burden. A notable treatment gap exists between the prevalence of depression and our ability to provide rapid-acting, effective treatment that achieves remission. Brexanolone and ...
Eamonn M Quigley,Fergus Shanahan
Eamonn M Quigley
Consumption of probiotic products continues to increase, perhaps driven by an interest in gut health. However, the field is filled with controversy, inconsistencies, misuse of terminology, and poor communication. While the probiotic concept...
Medical Therapy Alone, Percutaneous Coronary Intervention, or Coronary Artery Bypass Grafting for Treatment of Coronary Artery Disease [0.03%]
仅药物治疗、经皮冠状动脉介入治疗或冠状动脉旁路移植术治疗冠心病的效果比较研究
Daniel K Amponsah,William F Fearon
Daniel K Amponsah
In this review, we describe how the management of coronary artery disease (CAD) has become increasingly complex due to the rapid evolution of pharmacotherapy and procedural techniques. The expanding array of treatment options has driven res...
The Genetic Basis of Sudden Cardiac Death: From Diagnosis to Emerging Genetic Therapies [0.03%]
突发性心脏死亡的遗传基础：从诊断到新兴的基因治疗
Enya Dewars,Andrew Landstrom
Enya Dewars
Sudden cardiac death (SCD) is an abrupt, tragic manifestation of a number of cardiovascular diseases, primarily ion channelopathies and heritable cardiomyopathies. Because these diseases are heritable, genetics play a key role in the diagno...
James P Ho,William J Powers
James P Ho
In the past decade, adding mechanical thrombectomy (MT) of intracranial arterial occlusions to intravenous (IV) thrombolysis has revolutionized the treatment of acute ischemic stroke (AIS) by expanding the therapeutic window to 24 h. Treatm...
Riccardo Pofi,Dario De Alcubierre,Jiawen Dong et al.
Riccardo Pofi et al.
This review explores the evolving landscape of treatments for hypercortisolism, highlighting both established and emerging therapies. Although surgery remains the cornerstone of management, medical therapies play a crucial and expanding rol...