Barnett S Kramer,Jennifer Miller Croswell
Barnett S Kramer
The concept of early detection of cancer holds great promise and intuitive appeal. However, powerful biases can mislead clinicians when evaluating the efficacy of screening tests by clinical observation alone. Selection bias, lead-time bias...
Robert S Bresalier
Robert S Bresalier
The incidence of esophageal adenocarcinoma (EAC) has risen dramatically over the past three decades in western countries. The importance of Barrett's esophagus (BE) derives from its potential to transform to adenocarcinoma. BE is characteri...
Role of endothelin receptor antagonists in the treatment of pulmonary arterial hypertension [0.03%]
内皮素受体拮抗剂治疗肺动脉高压的作用
Steven H Abman
Steven H Abman
Pulmonary arterial hypertension (PAH) is a severe disease with marked morbidity and mortality for which therapeutic strategies have been limited. Basic research in vascular biology has implicated endothelin-1 (ET-1) and its receptors (ET(A)...
John D Birkmeyer,Justin B Dimick
John D Birkmeyer
Surgical mortality varies widely across hospitals and surgeons, more so than would be predicted by chance alone or differences in case mix. Although a large body of research has suggested the importance of procedure volume, clinical mechani...
Bradley A Maron,Joseph Loscalzo
Bradley A Maron
The unique biochemical profile of homocysteine is characterized by chemical reactivity supporting a wide range of molecular effects and by a tendency to promote oxidant stress-induced cellular toxicity. Numerous epidemiological reports have...
Steven S Sharfstein
Steven S Sharfstein
The purpose of the psychiatric hospital changed dramatically during the twentieth century. Formerly the primary location for psychiatric treatment, the hospital now plays a more circumscribed role within a community-based system of care. Cr...
Scott H Sicherer,Hugh A Sampson
Scott H Sicherer
Food allergies, defined as an adverse immune response to food proteins, affect as many as 6% of young children and 3%-4% of adults in westernized countries, and their prevalence appears to be rising. In addition to well-recognized acute all...