Application and Expectations for Immune Checkpoint Blockade of LAG3 and TIGIT [0.03%]
LAG3和TIGIT免疫检查点抑制剂的应用及展望
Ecaterina Elena Dumbrava,Khaoula Ben Haj Frej,Elad Sharon et al.
Ecaterina Elena Dumbrava et al.
Immune checkpoint blockade targeting the novel targets of the lymphocyte activation gene 3 (LAG3) and the T cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibition motif domains (TIGIT) has marked a significant advancement ...
Emily F Eix,Jeniel E Nett
Emily F Eix
Candida auris is a recently emerged fungal pathogen that causes severe infections in healthcare settings around the globe. A feature that distinguishes C. auris from other fungal pathogens is its high capacity to colonize skin, leading to w...
Anthony Ghanem,Susan M Domchek
Anthony Ghanem
Pathogenic variants in BRCA1 and BRCA2 are associated with significantly elevated lifetime risks of breast, ovarian, pancreatic, and prostate cancer. These genes are critical in double-strand break repair through homologous recombination. A...
Lessons from the Use of Monoclonal Antibodies to SARS-CoV-2 Spike Protein During the COVID-19 Pandemic [0.03%]
新冠大流行期间SARS-CoV-2刺突蛋白单克隆抗体的使用及其教训
Arturo Casadevall,Daniele Focosi
Arturo Casadevall
Monoclonal antibodies (mAbs) targeting the SARS-CoV-2 Spike protein were deployed during the COVID-19 pandemic. While all of the clinically authorized mAbs were eventually defeated by SARS-CoV-2 variants, they were highly effective in preve...
Kimberly Ryan,Lidija McGrath,Kathleen Brookfield
Kimberly Ryan
Chronic hypertension and preeclampsia spectrum disorders in pregnancy are important contributors to long-term maternal morbidity and mortality. Due to physiologic changes during pregnancy and the postpartum period, blood pressure expectatio...
Biologic Medications for Severe Asthma: Implications for Understanding Pathogenic Heterogeneity and Endotypes [0.03%]
严重哮喘的生物制剂：对病理异质性和亚型的理解的影响
Richard P Ramonell,Marc C Gauthier,Anuradha Ray et al.
Richard P Ramonell et al.
Asthma is a chronic inflammatory disease of the airways long known for phenotypic heterogeneity. Phenotyping studies in asthma have led to a better characterization of disease pathogenesis, yet further work is needed to pair available treat...
Saravanakkumar Chennappan,Maria Irene Kontaridis
Saravanakkumar Chennappan
RASopathies are a group of clinically overlapping autosomal dominant disorders caused primarily by mutations in genes that reside along the canonical Ras-mitogen-activated protein kinase signaling cascade. Though individually rare, collecti...
Circulating Tumor DNA: A Pan-Cancer Biomarker in Solid Tumors with Prognostic and Predictive Value [0.03%]
循环肿瘤DNA：实体瘤中的全癌种生物标志物及其预后和预测价值
Nadia Hitchen,Adel Shahnam,Jeanne Tie
Nadia Hitchen
Circulating tumor DNA (ctDNA), often referred to as a liquid biopsy, represents a promising biomarker in the management of both localized and advanced solid tumors. It has garnered significant attention due to its potential to inform progno...
Peter D Zang,Arkhjamil Angeles,Sumanta K Pal
Peter D Zang
CD70 is an emerging target for anticancer therapies. It is an ideal antigen target given its limited expression in normal physiologic tissues and propensity to be aberrantly expressed in a variety of malignancies, thus limiting off-target t...
Omprakash Shete,Tarini Shankar Ghosh
Omprakash Shete
The human microbiome is a sensor and modulator of physiology and homeostasis. Remarkable tractability underpins the promise of therapeutic manipulation of the microbiome. However, the definition of a normal or healthy microbiome has been el...