New Oral Selective Estrogen Receptor Degraders Redefine Management of Estrogen Receptor-Positive Breast Cancer [0.03%]
新型口服选择性雌激素受体降解剂重新定义了雌激素受体阳性乳腺癌的治疗标准
Neha Pathak,Mafalda Oliveira
Neha Pathak
Oral selective estrogen receptor degraders (SERDs) are pure estrogen receptor antagonists that have the potential to overcome common resistance mechanisms to endocrine therapy in estrogen receptor-positive breast cancer. There are currently...
Saro Khemichian,Mitra K Nadim,Norah A Terrault
Saro Khemichian
Hepatorenal syndrome-acute kidney injury (HRS-AKI) occurs in the setting of advanced chronic liver disease, portal hypertension, and ascites. HRS-AKI is found in ∼20% of patients presenting to the hospital with AKI, but it may coexist with...
Cheríe S Blair,Mary Catherine Cambou,Raphael J Landovitz
Cheríe S Blair
Despite rapid advances in the field of HIV prevention and treatment, unacceptably high global HIV incidence rates highlight the ongoing need for effective HIV prevention interventions for populations at risk for HIV acquisition. This articl...
Hidradenitis Suppurativa [0.03%]
化脓性汗腺炎
S McCarthy
S McCarthy
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by the formation of nodules, abscesses, and fistulae at intertriginous sites. Pain, pruritus, malodor, and suppuration have a significant impact on quality o...
Long-Term Risks of Living Kidney Donation: State of the Evidence and Strategies to Resolve Knowledge Gaps [0.03%]
活体肾脏捐献的长期风险：现有证据及填补知识空白的方法
Vidya A Fleetwood,Ngan N Lam,Krista L Lentine
Vidya A Fleetwood
Living-donor kidney transplantation is the preferred treatment for kidney failure. In the United States, rates of living kidney donation have been stagnant, which is partly related to concerns over medical and financial risks. Recent resear...
Maia Kayal,Brigid Boland
Maia Kayal
Chronic pouchitis (CP) occurs in approximately 20% of patients with ulcerative colitis after total proctocolectomy with ileal pouch anal anastomosis and is categorized as antibiotic dependent, antibiotic refractory, or Crohn's disease-like....
Michela Faggioni,Jay Giri,Lauren Glassmoyer et al.
Michela Faggioni et al.
Over the past decade, new modalities have emerged to treat acute pulmonary embolism (PE). However, PE remains a leading cause of morbidity and mortality worldwide. In the absence of robust clinical trial data and definitive guidelines and r...
Fady F Youssef,Laurel L Branch,Mark Kowalczyk et al.
Fady F Youssef et al.
The endoscopic evaluation and management of small intestinal diseases continue to evolve and expand. The advent of small bowel wireless capsule endoscopy and deep enteroscopy with either a double- or single-balloon enteroscope now allows co...
Abhay Singh,Akriti G Jain,Betty K Hamilton et al.
Abhay Singh et al.
The population of cancer survivors is on the rise due to an increase in cancer incidence and a decline in cancer mortality. This growing survivor population creates a number of challenges. Although there have been improvements in care plann...
Emmanuel B Walter,Flor M Munoz
Emmanuel B Walter
There have been several recent advances in the prevention of lower respiratory tract disease (LRTD) due to respiratory syncytial virus (RSV) infection in older adults and young children. Three different vaccines are now approved for use in ...