Tatsuro Ibe,Barry A Borlaug
Tatsuro Ibe
Glucagon-like peptide 1 receptor (GLP-1R) agonists were originally developed as treatments for diabetes and subsequently evolved into weight management medications. These drugs have recently been shown to demonstrate remarkable efficacy in ...
Tiffani J Bright,Keith C Norris
Tiffani J Bright
Artificial intelligence (AI) is transforming biomedical research, public health, and clinical care by offering opportunities to improve outcomes and advance health equity. Its promise stems from its ability to analyze complex health data to...
Contemporary Treatment Strategies in Pulmonary Hypertension: A Clinician's Guide [0.03%]
肺动脉高压的当代治疗策略——临床医师指南
Brandon Budhram,Samuel Chung,Marc Humbert et al.
Brandon Budhram et al.
Pulmonary hypertension (PH) is a complex condition characterized by pulmonary vasculopathy and progressive right ventricular dysfunction. Recent advances have reshaped PH management, including refined risk stratification, improved patient p...
Muscarinic Acetylcholine Receptor Activators as Transformative Therapeutics for Schizophrenia [0.03%]
muscarinic乙酰胆碱受体激动剂作为治疗精神分裂症的变革性药物
P Jeffrey Conn,Steven M Paul
P Jeffrey Conn
While traditional antipsychotic drugs provide symptomatic relief for positive symptoms in patients with schizophrenia, many patients are refractory to traditional antipsychotics. Furthermore, these medicines are ineffective in treating nega...
Joseph M Ladowski,Nagham Bazzi,Allan D Kirk
Joseph M Ladowski
Xenotransplantation of genetically modified pig organs has the potential to change the landscape of transplantation and chronic disease management by providing limitless personalized organs on demand. Decades of progress have resulted in re...
Tamarinde L Haven,John P A Ioannidis
Tamarinde L Haven
Reproducibility concerns in biomedical research have persisted for more than a decade, with large-scale assessments revealing significant challenges in replicating findings. Despite widespread acknowledgment of these issues, responses remai...
Jeong Uk Lim,Marcelo V Negrao,David S Hong
Jeong Uk Lim
This review examines the evolving treatment landscape for KRAS-mutant non-small cell lung cancer (NSCLC), along with the significance of KRAS mutations. The development of KRAS G12C inhibitors, such as sotorasib and adagrasib, has changed t...
Joseph Pechacek,Michail S Lionakis
Joseph Pechacek
Novel biologic therapies in the form of monoclonal antibodies and small molecule kinase inhibitors have transformed the management of several autoimmune, inflammatory, and neoplastic diseases. However, some of these biologics produce comple...
John M Carethers,Folasade P May
John M Carethers
Noninvasive tests for colorectal cancer (CRC) screening in average-risk individuals continue to evolve, with the premise of increasing screening participation among eligible individuals. In addition to fecal immunochemical testing (FIT), wh...
Chronic Cough Hypersensitivity as a Neuropathic Disorder: Implications for Management and New Treatments [0.03%]
慢性咳嗽超敏反应的神经病理性疾患属性：对治疗和管理的启示及新的治疗方法
Kian Fan Chung,Stuart B Mazzone
Kian Fan Chung
Chronic cough can coexist with or without pulmonary and extrapulmonary conditions and can be refractory to therapies that improve these associated conditions. It is underlined by cough hypersensitivity, which is characterized by increased c...