CGRP and Migraine: Real World Insights and Future Therapeutic Directions [0.03%]
降钙素基因相关肽与偏头痛：真实世界认知及未来治疗展望
Andrew F Russo,Eric A Kaiser
Andrew F Russo
Therapeutic targeting of the neuropeptide calcitonin gene-related peptide (CGRP) is a bench-to-bedside success story that has established migraine as a treatable neurological disorder. There are now eight monoclonal antibodies and small-mol...
Justin R Clark,Anthony W Maresso
Justin R Clark
Wastewater-based epidemiology (WBE) is the analysis of wastewater to detect pathogen levels or activity for public health awareness or action. Pioneered in the 1940s, WBE underwent a resurgence during the COVID-19 pandemic, providing import...
Susanne B Nicholas,Niloofar Nobakht,Radica Z Alicic
Susanne B Nicholas
Chronic kidney disease (CKD) affects 35.5 million US adults, but most patients are unaware of their diagnosis. Screening for CKD at-risk individuals is required, as symptoms do not appear until advanced stages. The combination of urine albu...
Anne Sophie Sølling,Bente L Langdahl,Felicia Cosman
Anne Sophie Sølling
Postmenopausal osteoporosis is a chronic progressive disease related to estrogen deficiency at menopause, aging, and superimposed genetic and environmental factors. Many patients with osteoporosis are not diagnosed, and the majority are not...
Regulatory T Cell Depletion in Cancer: Challenges, Opportunities, and Future Directions for Antibody Development [0.03%]
癌症中的调节性T细胞耗竭：抗体开发的挑战、机遇和未来方向
Mariela Navarrete,Cristobal Costoya,Felipe Galvez-Cancino et al.
Mariela Navarrete et al.
Regulatory T cells (Tregs) accumulate in the tumor microenvironment, where they suppress antitumor immunity and hinder immunotherapy efficacy. Antibody-mediated Treg depletion has emerged as a promising strategy, but its clinical translatio...
Lipoprotein(a): An Underappreciated Inherited Risk Factor for Atherosclerosis, Aortic Stenosis, and Abdominal Aortic Aneurysm [0.03%]
脂蛋白(a)：一种未被重视的动脉粥样硬化、主动脉瓣狭窄和腹主动脉瘤的遗传性危险因素
Marlys L Koschinsky,Dinesh K Kalra,Michael B Boffa
Marlys L Koschinsky
Elevated plasma concentration of lipoprotein(a) is a highly prevalent, independent, and causal risk factor for the development of numerous cardiovascular diseases. This review summarizes the key clinical evidence for elevated lipoprotein(a)...
Approach Toward Early Detection and Prevention of Early-Onset Colorectal Cancer [0.03%]
早期结直肠癌的早期检测和预防策略
Cassandra D L Fritz,Manju George,John M Carethers et al.
Cassandra D L Fritz et al.
Early-onset colorectal cancer (CRC), commonly defined as a CRC diagnosis before 50 years of age, is rapidly increasing. Despite overt symptoms, younger patients with early-onset CRC endure prolonged diagnostic delays. This review urgently d...
Maria Effenberger,Herbert Tilg
Maria Effenberger
Artificial sweeteners are widely used worldwide, yet their potential health effects remain a topic of debate. Recent studies suggest that artificial sweeteners, both nutritive and nonnutritive, may stimulate appetite, leading to increased c...
To Beat or Not to Beat: When and How to Treat Premature Ventricular Complexes [0.03%]
治疗过早室性收缩：何时及如何治疗？
Andres Enriquez,Matthew Hanson,Fermin Garcia
Andres Enriquez
Premature ventricular complexes (PVCs) are prevalent arrhythmias and a common reason for cardiac consultation. While often benign, PVCs can be markers of underlying heart disease and result in significant symptoms, left ventricular dysfunct...
Kawasaki Disease Vasculitis: From Diagnosis to New Concepts in Pathophysiology and Therapeutic Approaches [0.03%]
川崎病血管炎：从诊断到病理生理和治疗的新概念
Magali Noval Rivas,Moshe Arditi
Magali Noval Rivas
Kawasaki disease (KD) is an acute, self-limiting vasculitis that primarily affects children under 5 years old. KD manifests as a persistent fever in the presence of mucocutaneous inflammation and lymphadenopathy, which in severe cases leads...