Zhimin Fu,Yuxin Yang,Mina K Chung et al.
Zhimin Fu et al.
With the pharmacokinetics, dosing, safety, and manufacturing of approved or investigational drugs already well-characterized, drug repurposing and repositioning offer emerging strategies to rapidly develop effective treatments for various c...
Arun Rajasekaran,Dana V Rizk,Kirk N Campbell
Arun Rajasekaran
Immunoglobulin A nephropathy (IgAN) remains the leading primary glomerular disease worldwide, with a majority of patients reaching kidney failure within their lifetimes. IgAN is a heterogeneous glomerular disorder characterized by mesangial...
S Shahzad Mustafa,Aikaterini Anagnostou,Matthew Greenhawt
S Shahzad Mustafa
Peanut allergy is a significant rising public health problem affecting both children and adults. Early peanut introduction has been adopted in multiple westernized nations as a preventative strategic measure to reduce the risk of developing...
Sara Ghoneim,Michael G Drage,Kristin E Burke
Sara Ghoneim
Microscopic colitis (MC), which predominately affects older adults, is a chronic inflammatory bowel disease characterized by watery diarrhea. Diagnosis relies on histological examination, as there are no established biomarkers to facilitate...
Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis-Related Fibrosis: Therapeutic Options and Approaches to Treatment [0.03%]
与代谢异常相关脂肪性肝病和代谢异常相关非酒精性脂肪型肝炎相关的纤维化：治疗选择及治疗方法
Monica A Tincopa,Elizabeth K Speliotes,Luca Valenti et al.
Monica A Tincopa et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease impacting one-third of the adult population worldwide. MASLD has substantial associated morbidity and mortality, including progress...
Nephrolithiasis: A Paleolithic Perspective and Physiological Approach to Prevention [0.03%]
从旧石器时代视角和生理学角度预防肾结石
Calyani Ganesan,Lynda Frassetto,Alan C Pao
Calyani Ganesan
We take a Paleolithic perspective to account for why nephrolithiasis afflicts so many people and review evidence suggesting that the rapid shift in the human diet 10,000 years ago was a key event that increased stone risk in the modern era....
Hussein Sultan,Robert D Schreiber
Hussein Sultan
The past century has witnessed a paradigm shift in our understanding of the immune system's impact on tumor immunogenicity, outgrowth, and therapy. These advances come not only as a consequence of our enhanced appreciation for the mechanism...
Samantha D Minc,Katharine L McGinigle
Samantha D Minc
Peripheral artery disease (PAD) is a prevalent and underdiagnosed atherosclerotic condition affecting more than 10 million adults in the United States. PAD is a marker of systemic vascular disease and a strong predictor of myocardial infarc...
Rodrigo Paredes,S Daniel Haldar,Shubham Pant et al.
Rodrigo Paredes et al.
Cancer immunotherapy has advanced through immune checkpoint inhibitors and T cell therapies, yet challenges persist in overcoming immune evasion. Neoantigen-based vaccines have shown promise, particularly in tumors with high tumor mutation ...
Celine Yeh,Margaret C Wheless,Kristen K Ciombor et al.
Celine Yeh et al.
For decades, the management of locally advanced rectal cancer has been trimodal therapy with radiotherapy, surgery, and chemotherapy. Collectively, the adoption of total neoadjuvant therapy (TNT), advances in how radiotherapy and chemothera...