Valvular Heart Disease: New Concepts in Pathophysiology and Therapeutic Approaches [0.03%]
瓣膜性心脏病：病理生理学及治疗的新概念
Mackram F Eleid,Vuyisile T Nkomo,Sorin V Pislaru et al.
Mackram F Eleid et al.
This review discusses recent advancements in the field of valvular heart disease. Topics covered include recognition of the impact of atrial fibrillation on development and assessment of valvular disease, strategies for global prevention of...
All the Tau We Cannot See [0.03%]
我们看不到的所有倒数
Bradley Hyman
Bradley Hyman
Alzheimer's disease (AD) was described in 1906 as a dementing disease marked by the presence of two types of fibrillar aggregates in the brain: neurofibrillary tangles and senile plaques. The process of aggregation and formation of the aggr...
Mark D Elliott,Hila Milo Rasouly,Ali G Gharavi
Mark D Elliott
Hundreds of different genetic causes of chronic kidney disease are now recognized, and while individually rare, taken together they are significant contributors to both adult and pediatric diseases. Traditional genetics approaches relied he...
Primary Aldosteronism and the Role of Mineralocorticoid Receptor Antagonists for the Heart and Kidneys [0.03%]
原发性醛固酮增多症和盐皮质激素受体拮抗剂对心脏及肾脏的影响
Jordana B Cohen,Irina Bancos,Jenifer M Brown et al.
Jordana B Cohen et al.
Primary aldosteronism (PA) is the most common cause of secondary hypertension but is frequently underrecognized and undertreated. Patients with PA are at a markedly increased risk for target organ damage to the heart and kidneys. While pati...
Cytomegalovirus Therapy: Role of Letermovir in Prophylaxis and Treatment in Transplant Recipients [0.03%]
巨细胞病毒的治疗：Letermovir在移植受者的预防和治疗中的作用
Jennifer L Saullo,Rachel A Miller
Jennifer L Saullo
Cytomegalovirus (CMV) is a common viral pathogen in the transplant population and is associated with significant morbidity and mortality. CMV prevention is paramount; however, selecting the best preventive strategy depends on many factors i...
Multispecific CAR T Cells Deprive Lymphomas of Escape via Antigen Loss [0.03%]
多特异性CAR T细胞通过抗原丢失剥夺淋巴瘤的逃逸途径
Fateeha Furqan,Nirav N Shah
Fateeha Furqan
Chimeric antigen receptor (CAR) modified T cell therapy has transformed the management of relapsed/refractory B cell malignancies. Despite high overall response rates, relapse post CAR T treatment remains a clinical challenge. Loss of targe...
Alyxandra Ramsay,Joshua D Safer
Alyxandra Ramsay
Transgender people often face barriers in health care due to lack of access to care, lack of knowledgeable healthcare professionals, discrimination, and gaps in medical and mental health research. Existing research on transgender health has...
Lessons Learned from the ISCHEMIA Trial for the Management of Patients with Stable Ischemic Heart Disease [0.03%]
ISCHEMIA试验对稳定型缺血性心脏病患者的管理启示
William E Boden,Peter H Stone
William E Boden
The recent landmark International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial was undertaken to assess whether stable angina patients with moderate to severe baseline ischemia would benefi...
Aniruddh P Patel,Amit V Khera
Aniruddh P Patel
Polygenic scores quantify inherited risk by integrating information from many common sites of DNA variation into a single number. Rapid increases in the scale of genetic association studies and new statistical algorithms have enabled develo...
Gender-Affirming Care of Transgender and Gender-Diverse Youth: Current Concepts [0.03%]
青少年性别确认护理：当前概念
Janet Y Lee,Stephen M Rosenthal
Janet Y Lee
Increasing numbers of transgender and gender-diverse (TGD) youth, from early puberty through late adolescence, are seeking medical services to bring their physical sex characteristics into alignment with their gender identity-their inner se...