Alfred L Garfall
Alfred L Garfall
Multiple myeloma is a cancer of bone marrow plasma cells that represents approximately 10% of hematologic malignancies. Though it is typically incurable, a remarkable suite of new therapies developed over the last 25 years has enabled durab...
Treatments for COVID-19 [0.03%]
COVID-19的治疗措施
Hayden S Andrews,Jonathan D Herman,Rajesh T Gandhi
Hayden S Andrews
The treatment for COVID-19 has evolved rapidly since the start of the pandemic and now consists mainly of antiviral and immunomodulatory agents. Antivirals, such as remdesivir and nirmatrelvir-ritonavir, have proved to be most useful earlie...
Konstantin A Krychtiuk,L Kristin Newby
Konstantin A Krychtiuk
Rapid and accurate triage of patients presenting with chest pain to an emergency department (ED) is critical to prevent ED overcrowding and unnecessary resource use in individuals at low risk of acute myocardial infarction (AMI) and to effi...
Mahmut S Kaymakci,Kenneth J Warrington,Tanaz A Kermani
Mahmut S Kaymakci
Giant cell arteritis (GCA) and Takayasu arteritis (TAK) are large-vessel vasculitides affecting the aorta and its branches. Arterial damage from these diseases may result in ischemic complications, aneurysms, and dissections. Despite their ...
Expansion of Anticomplement Therapy Indications from Rare Genetic Disorders to Common Kidney Diseases [0.03%]
补体抑制疗法适应症从罕见遗传病向常见肾病拓展
Takashi Miwa,Sayaka Sato,Madhu Golla et al.
Takashi Miwa et al.
Complement constitutes a major part of the innate immune system. The study of complement in human health has historically focused on infection risks associated with complement protein deficiencies; however, recent interest in the field has ...
Stephen W Duffy,Lucie de Jonge,Thomas E Duffy
Stephen W Duffy
The COVID-19 pandemic led to disruption of health services around the world, including cancer services. We carried out a narrative review of the effect of the pandemic on cancer prevention services, including screening. Services were severe...
Matthew R Dent,Jason J Rose,Jesús Tejero et al.
Matthew R Dent et al.
Carbon monoxide (CO) poisoning leads to 50,000-100,000 emergency room visits and 1,500-2,000 deaths each year in the United States alone. Even with treatment, survivors often suffer from long-term cardiac and neurocognitive deficits, highli...
Mark Chandy,Masataka Nishiga,Tzu-Tang Wei et al.
Mark Chandy et al.
Cannabis, the most commonly used recreational drug, is illicit in many areas of the world. With increasing decriminalization and legalization, cannabis use is increasing in the United States and other countries. The adverse effects of canna...
Irma Husain,Xunrong Luo
Irma Husain
Despite significant advances in the field of transplantation in the past two decades, current clinically available therapeutic options for immunomodulation remain fairly limited. The advent of calcineurin inhibitor-based immunosuppression h...
Rupali Avasare,Nicole Andeen,Laurence Beck
Rupali Avasare
Membranous nephropathy (MN), an autoimmune kidney disease and leading cause of nephrotic syndrome, leads to kidney failure in up to one-third of affected individuals. Most MN cases are due to an autoimmune reaction against the phospholipase...