Phylogenomic Approaches to Study Adaptive Evolution in Mammals: From Aging to Aquatic Lifestyles [0.03%]
从衰老到水生生活方式：研究哺乳动物适应性进化的方法
Nathan L Clark,Amanda Kowalczyk,Emily E K Kopania et al.
Nathan L Clark et al.
The natural world is full of valuable lessons about genetic adaptation as organisms respond to changing conditions around them. Deciphering these changes is a major goal of evolutionary genetics. Advances have been made through phylogenomic...
Anne E West
Anne E West
The brain has a remarkable ability to adapt its function in response to both environmental and internal cues. The cellular composition of the brain is largely static after birth; thus, persistent experience-dependent changes in brain functi...
Fueling the Mind: Brain Metabolism in Health and Neurodevelopmental Disorders [0.03%]
思维燃料：健康和神经发育障碍中的脑代谢
Domenico Marano,Vittoria Mariano,Gaia Novarino
Domenico Marano
The adult human brain, under resting conditions, consumes approximately 20% of total body glucose, a demand that is even higher during the first decade of life. The brain metabolic landscape is intricately regulated throughout development, ...
Longhua Guo
Longhua Guo
Species such as planarians expand our horizons of imagination and fuel innovation. The ability to regenerate any tissues lost to injury has fascinated many generations of biologists studying regenerative biology. Recent experimental data ha...
Ross C Hardison
Ross C Hardison
Studies of globin gene clusters have established many paradigms of gene regulation. This review focuses on the α- and β-globin gene clusters of humans and mice, summarizing important insights from high-throughput biochemical assays and di...
Nathan T Mortimer,Todd A Schlenke
Nathan T Mortimer
Parasitoid wasps are a large and diverse group of species that infect a wide variety of insect hosts. In response, hosts have evolved numerous defensive strategies to protect against infection. Here, we review the immune and behavioral defe...
From Human to Mouse and Back: Genetic and Genomic Ta(i)les of Islet Dysfunction in Type 2 Diabetes [0.03%]
从人到小鼠再回到人：2 型糖尿病胰岛功能障碍的遗传和基因组研究故事
Romy Kursawe,Khushdeep Bandesh,Sai Nivedita Krishnan et al.
Romy Kursawe et al.
Type 2 diabetes (T2D) is a complex genetic disease with substantial environmental inputs leading to glucose homeostasis defects. Insulin production is central to proper glucose control, and islet cell dysfunction and death lie at the nexus ...
Evaluating Selective Quality Control in Mammalian Oogenesis: Evidence and Opportunities [0.03%]
评价哺乳动物卵母细胞发生中选择性质量控制的证据与机遇
Jay W Zussman,Dominic J Skinner,Daniel E Wagner et al.
Jay W Zussman et al.
The formation and maintenance of the finite mammalian ovarian reserve are critical for fertility and species survival. Genetic and developmental studies have uncovered various mechanisms underlying oocyte development and maturation, reveali...
Forming a Complex: Turbocharging BMP Signal Activation by Heterodimeric Ligands and Heteromeric Receptor Complexes [0.03%]
异二聚体配体与异源受体复合物增强BMP信号转导
Jeet H Patel,Mary C Mullins
Jeet H Patel
Bone morphogenetic protein (BMP) signaling functions in a vast range of biological contexts. The basic signaling mechanism of this pathway is well-defined, with BMP ligand dimers recruiting tetrameric receptor complexes that phosphorylate S...
The Red Queen and the Timescale of Antagonistic Coevolution: Parasite Selection for Genetic Diversity [0.03%]
红皇后与拮抗性协同进化的时空尺度：寄生虫选择遗传多样性的机制
Dieter Ebert
Dieter Ebert
The Red Queen model of antagonistic coevolution has been the preferred explanation for certain biological phenomena, such as extreme genetic diversity and trans-species polymorphisms in disease genes. This model has been studied on diverse ...