Laura N Vogt,Kathrin S Fröhlich
Laura N Vogt
Decades of research into the noncoding transcriptome have unveiled a complex, multilayered web of molecular interactions that govern gene expression, protein synthesis, and cellular function, challenging the once-presumed linear simplicity ...
Context Specificity of MAP3K DLK Signaling in the Nervous System: Insights from Genetics and Genomics [0.03%]
神经系统的MAP3K DLK信号转导的背景特异性：来自遗传学和基因组学研究的新见解
Erin M Ritchie,Yishi Jin
Erin M Ritchie
The MAP3K dual-leucine zipper kinases are stress-sensing signaling molecules that have important roles in neuronal development and maintenance, traumatic injury, and neurodegeneration. These kinases activate signal transduction cascades and...
The Field of Hair Cell Regeneration Is Ready for Input from Genomics and Epigenetics [0.03%]
听觉毛细胞再生研究领域迎来基因组学及表观遗传学输入契机
Donald L Swiderski,Lindsey M Q Wilson,Yehoash Raphael
Donald L Swiderski
Cochlear hair cells are epithelial cells that are not replaced when lost, leading to permanent hearing loss. The lack of spontaneous regeneration of hair cells is a rarity in epithelial tissues, including hair cell epithelia. Evolutionary c...
Erica A Birkholz,Emily G Armbruster,Joe Pogliano
Erica A Birkholz
Nucleus-forming jumbo bacteriophages display a surprisingly intricate replication cycle inside of bacterial host cells, challenging the long-standing paradigm of prokaryotic simplicity. The phage nucleus encloses phage DNA in a protein shel...
Phylogenomic Approaches to Study Adaptive Evolution in Mammals: From Aging to Aquatic Lifestyles [0.03%]
从衰老到水生生活方式：研究哺乳动物适应性进化的方法
Nathan L Clark,Amanda Kowalczyk,Emily E K Kopania et al.
Nathan L Clark et al.
The natural world is full of valuable lessons about genetic adaptation as organisms respond to changing conditions around them. Deciphering these changes is a major goal of evolutionary genetics. Advances have been made through phylogenomic...
Anne E West
Anne E West
The brain has a remarkable ability to adapt its function in response to both environmental and internal cues. The cellular composition of the brain is largely static after birth; thus, persistent experience-dependent changes in brain functi...
Fueling the Mind: Brain Metabolism in Health and Neurodevelopmental Disorders [0.03%]
思维燃料：健康和神经发育障碍中的脑代谢
Domenico Marano,Vittoria Mariano,Gaia Novarino
Domenico Marano
The adult human brain, under resting conditions, consumes approximately 20% of total body glucose, a demand that is even higher during the first decade of life. The brain metabolic landscape is intricately regulated throughout development, ...
Longhua Guo
Longhua Guo
Species such as planarians expand our horizons of imagination and fuel innovation. The ability to regenerate any tissues lost to injury has fascinated many generations of biologists studying regenerative biology. Recent experimental data ha...
Ross C Hardison
Ross C Hardison
Studies of globin gene clusters have established many paradigms of gene regulation. This review focuses on the α- and β-globin gene clusters of humans and mice, summarizing important insights from high-throughput biochemical assays and di...
Nathan T Mortimer,Todd A Schlenke
Nathan T Mortimer
Parasitoid wasps are a large and diverse group of species that infect a wide variety of insect hosts. In response, hosts have evolved numerous defensive strategies to protect against infection. Here, we review the immune and behavioral defe...