Austen R D Ganley,Sylvie Hermann-Le Denmat
Austen R D Ganley
In eukaryotes, ribosomal RNA genes (rDNA) encode the major ribosomal RNA molecules and are typically organized into a distinctive genomic structure involving tandem repetition of a polycistronic coding region. Here, we review eukaryotic rDN...
Gaurav Singh,Kaveri Vaidya,Sunil Laxman
Gaurav Singh
A cell functions as a metabolic economy that parses information on nutrient availability and internal metabolic flux and then converts that to state outcomes that maintain or shift homeostasis. Here, we discuss how the nutrient-signaling ma...
Emma M Anderson,Barbara G Mellone
Emma M Anderson
Centromeres are essential chromosomal loci specified epigenetically by CENP-A chromatin, yet they undergo rapid sequence turnover, structural remodeling, and occasional repositioning. In this review, we integrate recent advances enabled by ...
Mitochondrial DNA Inheritance and Germline Purifying Selection: Insights From Drosophila [0.03%]
线粒体DNA遗传及生殖细胞纯化选择：果蝇研究中的洞见
Zhe Chen,Hong Xu
Zhe Chen
The mitochondrial genome resides in a highly mutagenic environment and is typically maternally inherited with little recombination, features that should render mitochondrial DNA (mtDNA) prone to the accumulation of deleterious variants. Con...
Robyn A Emmerson,Rebecca A Mosher
Robyn A Emmerson
Genomic imprinting is an epigenetic phenomenon in which chromosome behavior or gene expression depends on whether an allele was paternally or maternally inherited. Imprinting is commonly associated with a placenta or an analogous organ duri...
Natalie Warsinger-Pepe,Stacey L Hanlon
Natalie Warsinger-Pepe
Nonessential, supernumerary B chromosomes have been an intriguing anomaly known to researchers for over a century. B chromosomes were first identified in insects and have since been discovered in hundreds of species across many different ta...
Rini Mayangsari,Carol W Greider
Rini Mayangsari
Telomeres are sequences at chromosome ends that distinguish the natural end from a DNA break. Telomeres shorten at each round of cell division because the replisome cannot completely copy both DNA strands to the very end. This shortening is...
Mechanisms and Evolutionary Advantages of Unlimited Reproductive Lifespans in Naked Mole-Rat Queens [0.03%]
裸鼹鼠 queen 无限繁殖寿命的机制及其进化优势
Andrew C Pearson,Odei Barreñada,Miguel A Brieño-Enríquez
Andrew C Pearson
The naked mole-rat (Heterocephalus glaber) defies mammalian norms with lifelong fertility and postnatal oogenesis. Unlike most mammals, which experience reproductive senescence due to depletion of a finite ovarian follicle pool, naked mole-...
Laura N Vogt,Kathrin S Fröhlich
Laura N Vogt
Decades of research into the noncoding transcriptome have unveiled a complex, multilayered web of molecular interactions that govern gene expression, protein synthesis, and cellular function, challenging the once-presumed linear simplicity ...
Context Specificity of MAP3K DLK Signaling in the Nervous System: Insights from Genetics and Genomics [0.03%]
神经系统的MAP3K DLK信号转导的背景特异性：来自遗传学和基因组学研究的新见解
Erin M Ritchie,Yishi Jin
Erin M Ritchie
The MAP3K dual-leucine zipper kinases are stress-sensing signaling molecules that have important roles in neuronal development and maintenance, traumatic injury, and neurodegeneration. These kinases activate signal transduction cascades and...