Phosphoinositide Regulation of TRP Channels: A Functional Overview in the Structural Era [0.03%]
结构时代的TRP通道的磷脂调控功能概述
Tibor Rohacs
Tibor Rohacs
Transient receptor potential (TRP) ion channels have diverse activation mechanisms including physical stimuli, such as high or low temperatures, and a variety of intracellular signaling molecules. Regulation by phosphoinositides and their d...
Xin Rui Lim,Osama F Harraz
Xin Rui Lim
Mechanical forces influence different cell types in our bodies. Among the earliest forces experienced in mammals is blood movement in the vascular system. Blood flow starts at the embryonic stage and ceases when the heart stops. Blood flow ...
Intestinal Tuft Cells: Morphology, Function, and Implications for Human Health [0.03%]
肠道刷细胞：形态、功能及其对人类健康的影响
Jennifer B Silverman,Paige N Vega,Matthew J Tyska et al.
Jennifer B Silverman et al.
Tuft cells are a rare and morphologically distinct chemosensory cell type found throughout many organs, including the gastrointestinal tract. These cells were identified by their unique morphologies distinguished by large apical protrusions...
Jaime Ibarrola,Iris Z Jaffe
Jaime Ibarrola
Originally described as the renal aldosterone receptor that regulates sodium homeostasis, it is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in vascular endothelial and smooth muscle cells. Ample data dem...
Orhi Esarte Palomero,Megan Larmore,Paul G DeCaen
Orhi Esarte Palomero
Polycystin subunits can form hetero- and homotetrameric ion channels in the membranes of various compartments of the cell. Homotetrameric polycystin channels are voltage- and calcium-modulated, whereas heterotetrameric versions are proposed...
Thomas A Longden,Guiling Zhao,Ashwini Hariharan et al.
Thomas A Longden et al.
Pericytes, attached to the surface of capillaries, play an important role in regulating local blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with confocal and multiphoton imaging techniques, the 3D stru...
Molecular Physiology of TRPV Channels: Controversies and Future Challenges [0.03%]
瞬时受体电位香草酸亚型通道的分子生理学：争议与未来挑战
Tamara Rosenbaum,León D Islas
Tamara Rosenbaum
The ability to detect stimuli from the environment plays a pivotal role in our survival. The molecules that allow the detection of such signals include ion channels, which are proteins expressed in different cells and organs. Among these io...
Mechanisms of Protein Trafficking and Quality Control in the Kidney and Beyond [0.03%]
肾脏及其它器官中蛋白质运输和质量控制的机制研究进展
Jillian L Shaw,Juan Lorenzo Pablo,Anna Greka
Jillian L Shaw
Numerous trafficking and quality control pathways evolved to handle the diversity of proteins made by eukaryotic cells. However, at every step along the biosynthetic pathway, there is the potential for quality control system failure. This r...
Máté Katona,Mark T Gladwin,Adam C Straub
Máté Katona
Resistance arteries and arterioles evolved as specialized blood vessels serving two important functions: (a) regulating peripheral vascular resistance and blood pressure and (b) matching oxygen and nutrient delivery to metabolic demands of ...
Proprioception: A New Era Set in Motion by Emerging Genetic and Bionic Strategies? [0.03%]
本体感受：新的纪元是否由新兴的遗传和仿生策略开启？
Paul D Marasco,Joriene C de Nooij
Paul D Marasco
The generation of an internal body model and its continuous update is essential in sensorimotor control. Although known to rely on proprioceptive sensory feedback, the underlying mechanism that transforms this sensory feedback into a dynami...