Lorenzo Fabrizi,Maria Fitzgerald
Lorenzo Fabrizi
Pain is a fundamental human experience, but how does it begin? Noxious stimuli elicit strong behavioral and physiological responses, even in the youngest newborns, reflecting early subcortical engagement, but the actual experience of pain r...
Patrick A Link,Daniel J Tschumperlin
Patrick A Link
Pulmonary fibrosis is a devastating and progressive disease marked by replacement of gas-exchanging tissue with collagen-rich scar. The mechanical environment is profoundly altered in pulmonary fibrosis and contributes to disease progressio...
Decoding Connexin Hemichannels: Structure, Function, and Regulatory Mechanisms [0.03%]
连接蛋白半通道的解码：结构、功能及调节机制
Isaac E García,Jorge E Contreras
Isaac E García
Connexin hemichannels are pivotal for cellular communication, acting as independent conduits for ion and metabolite exchange, as well as precursors to gap junction channels. While their involvement in pathophysiological conditions, includin...
Tianlu Wang,Kai Zhang,Yubin Zhou
Tianlu Wang
Optogenetics and chemogenetics have transformed how physiologists interrogate biological systems by enabling precise control over protein activity and cellular function. Optogenetics uses light-sensitive proteins for rapid and localized con...
Annika Keller
Annika Keller
Primary familial brain calcification (PFBC) is a dominantly or recessively inherited neurodegenerative disease characterized by bilateral basal ganglia calcifications. Patients affected by PFBC present with diverse motor and nonmotor sympto...
Carmen A Mannella,Pawel Swietach,Liron Boyman
Carmen A Mannella
Mitochondrial ATP production dynamically adapts to cellular energy demands, with calcium (Ca2+) playing a crucial regulatory role. In this review, we critically evaluate the evidence for intramitochondrial Ca2+ ([Ca2+]m) sensitivity in key ...
Clemence Blouet,Gary J Schwartz
Clemence Blouet
Whole-body nutrient homeostasis is critical for healthy growth, successful reproduction, and survival. We propose a conceptual framework emphasizing the role of brain nutrient sensing in mediating adaptive responses for the maintenance of n...
Coordinated Remodeling of Ca2+ Signaling and Intracellular Organelles During Cell Division [0.03%]
细胞分裂过程中钙信号转导及胞器的协调重塑
Fang Yu,Lama Assaf,Khaled Machaca
Fang Yu
Cell division is essential for organismal growth and development and is associated with changes in signaling dynamics, including Ca2+ signaling, to meet structural, functional, and energetic needs. The process of cell division must ensure e...
Niels Pietsch,Sonia R Singh,Lucie Carrier
Niels Pietsch
Hypertrophic cardiomyopathy (HCM) is the most common myocardial genetic disease characterized by left ventricular hypertrophy (LVH) and diastolic dysfunction with preserved or elevated ejection fraction. Thirty-five years after the identifi...
The Proton-Activated Chloride Channel: Molecular Identification, Structure, and Role in Organelle Physiology [0.03%]
质子激活的氯通道：分子识别、结构及其在细胞器生理学中的作用
Kevin Hong Chen,Tatsuya Hagino,Zhaozhu Qiu
Kevin Hong Chen
In 2019, a novel membrane protein, PAC (also known as TMEM206), was identified as the long-sought molecular carrier of an acid- or proton-activated chloride current observed ubiquitously in mammalian cells. This discovery has led to rapid p...