A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy [0.03%]
以史为鉴，着眼未来，平衡施策应对阿片类药物滥用危机
Sarah Warren Gooding,Jennifer L Whistler
Sarah Warren Gooding
The harmful side effects of opioid drugs such as respiratory depression, tolerance, dependence, and abuse potential have limited the therapeutic utility of opioids for their entire clinical history. However, no previous attempt to develop e...
Metabolic Rewiring and Communication: An Integrative View of Kidney Proximal Tubule Function [0.03%]
代谢重构和通讯：肾近端小管功能的整合观点
Maria Chrysopoulou,Markus M Rinschen
Maria Chrysopoulou
The kidney proximal tubule is a key organ for human metabolism. The kidney responds to stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate cause for kidney disease. Here, we review the proximal tubule...
Charlotte A Hoogstraten,Joost G Hoenderop,Jeroen H F de Baaij
Charlotte A Hoogstraten
Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water and solute reabsorption processes along the nephron. Moreover, mitochondria contribute to cellular health by the regulation of ...
Cassandra J Hatzipantelis,David E Olson
Cassandra J Hatzipantelis
Psychedelics are quite unique among drugs that impact the central nervous system, as a single administration of a psychedelic can both rapidly alter subjective experience in profound ways and produce sustained effects on circuits relevant t...
Arohan R Subramanya,Cary R Boyd-Shiwarski
Arohan R Subramanya
The cytoplasm is densely packed with molecules that contribute to its nonideal behavior. Cytosolic crowding influences chemical reaction rates, intracellular water mobility, and macromolecular complex formation. Overcrowding is potentially ...
Adipose Tissue in Cardiovascular Disease: From Basic Science to Clinical Translation [0.03%]
心血管疾病中的脂肪组织研究：从基础科学到临床转化
Murray D Polkinghorne,Henry W West,Charalambos Antoniades
Murray D Polkinghorne
The perception of adipose tissue as a metabolically quiescent tissue, primarily responsible for lipid storage and energy balance (with some endocrine, thermogenic, and insulation functions), has changed. It is now accepted that adipose tiss...
Duane D Hall,Hiroshi Takeshima,Long-Sheng Song
Duane D Hall
In both excitable and nonexcitable cells, diverse physiological processes are linked to different calcium microdomains within nanoscale junctions that form between the plasma membrane and endo-sarcoplasmic reticula. It is now appreciated th...
Elisabetta Brunello,Luca Fusi
Elisabetta Brunello
Force generation in striated muscle is primarily controlled by structural changes in the actin-containing thin filaments triggered by an increase in intracellular calcium concentration. However, recent studies have elucidated a new class of...
Thomas E DeCoursey
Thomas E DeCoursey
A handful of biological proton-selective ion channels exist. Some open at positive or negative membrane potentials, others open at low or high pH, and some are light activated. This review focuses on common features that result from the uni...
Andrea L Meredith
Andrea L Meredith
Novel KCNMA1 variants, encoding the BK K+ channel, are associated with a debilitating dyskinesia and epilepsy syndrome. Neurodevelopmental delay, cognitive disability, and brain and structural malformations are also diagnosed at lower incid...