Arnav Sharma,Terren K Niethamer
Arnav Sharma
Endothelial cells (ECs) develop organ-specific gene expression and function in response to signals from the surrounding tissue. In turn, ECs can affect organ development and morphogenesis and promote or hinder disease response. In the lung,...
Charles N Serhan,Bruce D Levy
Charles N Serhan
Lung inflammation, infection, and injury can lead to critical illness and death. The current means to pharmacologically treat excessive uncontrolled lung inflammation needs improvement because many treatments are or will become immunosuppre...
From Muscle-Based Nonshivering Thermogenesis to Malignant Hyperthermia in Mammals [0.03%]
从基于肌肉的非战栗性产热到哺乳动物的恶性高热
Bradley S Launikonis,Robyn M Murphy
Bradley S Launikonis
For physiological processes in the vital organs of eutherian mammals to function, it is important to maintain constant core body temperature at ∼37°C. Mammals generate heat internally by thermogenesis. The focus of this review is on heat ...
A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome [0.03%]
刀锋上的舞蹈：急性炎症性肺损伤/急性呼吸窘迫综合征的血管反应
David R Price,Joe G N Garcia
David R Price
Historically considered a metabolically inert cellular layer separating the blood from the underlying tissue, the endothelium is now recognized as a highly dynamic, metabolically active tissue that is critical to organ homeostasis. Under ho...
Amira Klip,Katrien De Bock,Philip J Bilan et al.
Amira Klip et al.
Glucose is the universal fuel of most mammalian cells, and it is largely replenished through dietary intake. Glucose availability to tissues is paramount for the maintenance of homeostatic energetics and, hence, supply should match demand b...
Karina Cunha E Rocha,Wei Ying,Jerrold M Olefsky
Karina Cunha E Rocha
Exosomes are small extracellular vesicles that carry lipids, proteins, and microRNAs (miRNAs). They are released by all cell types and can be found not only in circulation but in many biological fluids. Exosomes are essential for interorgan...
Véronique Regnault,Patrick Lacolley,Stéphane Laurent
Véronique Regnault
The elastic properties of conductance arteries are one of the most important hemodynamic functions in the body, and data continue to emerge regarding the importance of their dysfunction in vascular aging and a range of cardiovascular diseas...
Geniver El Tekle,Natalia Andreeva,Wendy S Garrett
Geniver El Tekle
Studies in preclinical models support that the gut microbiota play a critical role in the development and progression of colorectal cancer (CRC). Specific microbial species and their corresponding virulence factors or associated small molec...
David Bradley,Tuo Deng,Dharti Shantaram et al.
David Bradley et al.
Obesity is epidemic and of great concern because of its comorbid and costly inflammatory-driven complications. Extensive investigations in mice have elucidated highly coordinated, well-balanced interactions between adipocytes and immune cel...
Ruiqi L Wang,Rui B Chang
Ruiqi L Wang
Interoception, the ability to precisely and timely sense internal body signals, is critical for life. The interoceptive system monitors a large variety of mechanical, chemical, hormonal, and pathological cues using specialized organ cells, ...