Jacques Gonzales,Brian D Gulbransen
Jacques Gonzales
Enteric glia are the partners of neurons in the enteric nervous system throughout the gastrointestinal tract. Roles fulfilled by enteric glia are diverse and contribute to maintaining intestinal homeostasis through interactions with neurons...
Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease [0.03%]
缺血性心脏病中心脏电活动异质性的机制及意义研究
Hector Martinez-Navarro,Xin Zhou,Blanca Rodriguez
Hector Martinez-Navarro
A healthy heart shows intrinsic electrical heterogeneities that play a significant role in cardiac activation and repolarization. However, cardiac diseases may perturb the baseline electrical properties of the healthy cardiac tissue, leadin...
Michael J Beacom,Alistair J Gunn,Laura Bennet
Michael J Beacom
Preterm fetuses and newborns have a high risk of neural injury and impaired neural maturation, leading to neurodevelopmental disability. Developing effective treatments is rather challenging, as preterm brain injury may occur at any time du...
Katharina Maisel,Hasina Outtz Reed
Katharina Maisel
The lymphatic vasculature maintains lung homeostasis via fluid drainage in the form of lymph and by facilitating immune surveillance and leukocyte trafficking to the draining lymph nodes. Previous studies in both humans and animal models ha...
Annet Kirabo,Sepiso K Masenga,Thomas R Kleyman
Annet Kirabo
Epithelial Na+ channels (ENaCs) are known to affect blood pressure through their role in transporting Na+ in the distal nephron of the kidney. While expressed in other epithelial tissues, there is growing evidence that ENaCs are also expres...
Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics [0.03%]
蛋白质酪氨酸磷酸酶与代谢：药物研发的新前沿
Anton M Bennett,Tony Tiganis
Anton M Bennett
The increased prevalence of chronic metabolic disorders, including obesity and type 2 diabetes and their associated comorbidities, are among the world's greatest health and economic challenges. Metabolic homeostasis involves a complex inter...
The Calcium Homeostasis of Human Red Blood Cells in Health and Disease: Interactions of PIEZO1, the Plasma Membrane Calcium Pump, and Gardos Channels [0.03%]
人类红细胞健康与疾病状态下的钙稳态：PIEZO1、质膜钙泵和Gardos通道的相互作用
Virgilio L Lew
Virgilio L Lew
Calcium ions mediate the volume homeostasis of human red blood cells (RBCs) in the circulation. The mechanism by which calcium ions affect RBC hydration states always follows the same sequence. Deformation of RBCs traversing capillaries bri...
Michael J Davis,Scott D Zawieja,Philip D King
Michael J Davis
Two major functions of the lymphatic system are the reabsorption of excess interstitial fluid/protein and the coordination of immune cell interactions and trafficking. Specialized junctions between lymphatic endothelial cells optimize reabs...
Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation [0.03%]
房性健康和房颤中的电生理学及钙处理的性别差异
Charlotte E R Smith,Haibo Ni,Eleonora Grandi
Charlotte E R Smith
The importance of biological sex on disease etiology and outcomes has long been underinvestigated. While recent focus on characterizing sex differences in cardiac pathophysiology has led to improved inclusion of both sexes in scientific stu...
Stathis Megas,Anna Wilbrey-Clark,Aidan Maartens et al.
Stathis Megas et al.
Over the last decade, single-cell genomics has revealed remarkable heterogeneity and plasticity of cell types in the lungs and airways. The challenge now is to understand how these cell types interact in three-dimensional space to perform l...