Savanna N Weninger,Andrew Manley,Frank A Duca
Savanna N Weninger
The gut microbiota is a salient contributor to the development of type 2 diabetes mellitus (T2D) as a vast and complex metabolic cross talk that exists between the bacteria residing in the gastrointestinal tract and the host. This cross tal...
Novel Advances in Our Understanding of Sex-Dependent Control of Blood Pressure [0.03%]
性别依赖的血压调控的新进展
Rachel Q Muir,Jiaojiao Xu,Alexandra D Medcalf et al.
Rachel Q Muir et al.
Sex differences in blood pressure are evident from puberty through menopause, with premenopausal females exhibiting lower blood pressure than males. This review discusses key factors contributing to sex differences in blood pressure, focusi...
Chloride-Dependent Cation Transport via SLC12 Carriers at Atomic Resolution [0.03%]
基于SLC12载体的氯化物依赖性阳离子运输的原子解析结构研究
Eric Delpire
Eric Delpire
The SLC12 family of genes encodes electroneutral Cl--dependent cation transporters (i.e., Na-Cl, K-Cl, Na-K-2Cl cotransporters), which play significant roles in maintaining cell and body homeostasis. Recent resolution of their structures at...
At the Crossroads of Health and Disease: Consequences of Fat in the Liver [0.03%]
在健康与疾病十字路口：肝脏脂肪的影响
Matthew Dukewich,Liyun Yuan,Norah A Terrault
Matthew Dukewich
The liver plays a central role in regulating lipid and glucose metabolism, particularly in transitioning between energy storage and provision in fed and fasting states. Loss of metabolic flexibility, characterized by the impaired capacity t...
Exercise as Mitochondrial Medicine: How Does the Exercise Prescription Affect Mitochondrial Adaptations to Training? [0.03%]
运动作为线粒体医学：运动处方如何影响训练中的线粒体适应？
David J Bishop,Matthew J-C Lee,Martin Picard
David J Bishop
Mitochondria are multifaceted organelles with several life-sustaining functions beyond energy transformation, including cell signaling, calcium homeostasis, hormone synthesis, programmed cell death (apoptosis), and others. A defining aspect...
The Heart is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect [0.03%]
心脏是一种智能泵：Frank-Starling定律和Anrep效应的力-电转导机制
Ye Chen-Izu,Tamas Banyasz,John A Shaw et al.
Ye Chen-Izu et al.
The Frank-Starling law and Anrep effect describe two intrinsic mechanisms that regulate contraction force in the heart. Based on recent advancements and the historical literature, we propose new perspectives and address several critical iss...
Inositol 1,4,5-Trisphosphate Receptor Mutations Associated with Human Disease: Insights into Receptor Function and Dysfunction [0.03%]
与人类疾病相关的肌醇三磷酸受体突变：对受体功能和功能障碍的见解
Vikas Arige,David M MacLean,David I Yule
Vikas Arige
Inositol 1,4,5-trisphosphate receptors (IP3Rs) are ubiquitous intracellular Ca2+ release channels. Their activation, subcellular localization, abundance, and regulation play major roles in defining the spatiotemporal characteristics of intr...
Sex, Gender, and COPD [0.03%]
性别、性和慢性阻塞性肺病
Dawn L DeMeo
Dawn L DeMeo
Sex and gender have emerged as critical considerations relevant to chronic obstructive pulmonary disease (COPD). Sex differences in lung development and physiologic response to hormones and environmental exposures influence COPD susceptibil...
Kirill S Korshunov,Murali Prakriya
Kirill S Korshunov
Store-operated Ca2+ entry (SOCE) is a widespread mechanism of cellular Ca2+ signaling that arises from Ca2+ influx across the plasma membrane through the Orai family of calcium channels in response to depletion of intracellular Ca2+ stores....
A Mechanistic Rationale for Incretin-Based Therapeutics in the Management of Obesity [0.03%]
基于增量的肥胖症治疗疗法的机制原因
Ricardo J Samms,Christine M Kusminski
Ricardo J Samms
Driven by increased caloric intake relative to expenditure, obesity is a major health concern placing economic and operational strain on healthcare and social care worldwide. Pharmacologically, one of the most effective avenues for the mana...