Carmen A Mannella,Pawel Swietach,Liron Boyman
Carmen A Mannella
Mitochondrial ATP production dynamically adapts to cellular energy demands, with calcium (Ca2+) playing a crucial regulatory role. In this review, we critically evaluate the evidence for intramitochondrial Ca2+ ([Ca2+]m) sensitivity in key ...
Clemence Blouet,Gary J Schwartz
Clemence Blouet
Whole-body nutrient homeostasis is critical for healthy growth, successful reproduction, and survival. We propose a conceptual framework emphasizing the role of brain nutrient sensing in mediating adaptive responses for the maintenance of n...
Coordinated Remodeling of Ca2+ Signaling and Intracellular Organelles During Cell Division [0.03%]
细胞分裂过程中钙信号转导及胞器的协调重塑
Fang Yu,Lama Assaf,Khaled Machaca
Fang Yu
Cell division is essential for organismal growth and development and is associated with changes in signaling dynamics, including Ca2+ signaling, to meet structural, functional, and energetic needs. The process of cell division must ensure e...
Niels Pietsch,Sonia R Singh,Lucie Carrier
Niels Pietsch
Hypertrophic cardiomyopathy (HCM) is the most common myocardial genetic disease characterized by left ventricular hypertrophy (LVH) and diastolic dysfunction with preserved or elevated ejection fraction. Thirty-five years after the identifi...
The Proton-Activated Chloride Channel: Molecular Identification, Structure, and Role in Organelle Physiology [0.03%]
质子激活的氯通道：分子识别、结构及其在细胞器生理学中的作用
Kevin Hong Chen,Tatsuya Hagino,Zhaozhu Qiu
Kevin Hong Chen
In 2019, a novel membrane protein, PAC (also known as TMEM206), was identified as the long-sought molecular carrier of an acid- or proton-activated chloride current observed ubiquitously in mammalian cells. This discovery has led to rapid p...
Juliana H Boukhaled,Emily M Martin,Nathalie Gayrard et al.
Juliana H Boukhaled et al.
Cardiorenal syndrome (CRS) represents a complex interplay of pathophysiological processes that create a self-perpetuating cycle of heart and kidney dysfunction. While it is clearly understood how hemodynamic changes connect pathogenesis in ...
Role of Diverse Smooth Muscle Cell Phenotypic Transitions in Atherosclerosis Development and Late-Stage Pathogenesis [0.03%]
血管平滑肌细胞表型转化在动脉粥样硬化发生发展中的作用及晚期病理学意义研究进展
Vlad Serbulea,James M Martin,Gary K Owens
Vlad Serbulea
Major adverse cardiovascular events resulting from atherosclerotic plaque instability account for a plurality of deaths worldwide despite the use of highly effective lipid lowering therapies. Over the last three decades, the role of inflamm...
Leptin: 30 Years Later [0.03%]
瘦素研究三十载
Rexford S Ahima,Jeffrey S Flier
Rexford S Ahima
The discovery of leptin as an adipocyte-secreted hormone encoded by the ob gene whose absence produces severe obesity that is corrected by leptin repletion in both mice and humans was a transformative event in metabolic science. Leptin's di...
Amit Grover,Evgenii N Tcyganov,Dmitry I Gabrilovich
Amit Grover
Plasticity of myeloid cells, characterized by their ability to undergo reprogramming in response to environmental cues, is a fundamental feature enabling their versatile functions during immune responses. Macrophages and neutrophils, the pr...
Francesca Polverino,Don D Sin
Francesca Polverino
Approximately two-thirds of cases of chronic obstructive pulmonary disease (COPD) and adult asthma are in part driven by impaired lung development related to early-life events. Many children who suffer insults to their lungs during the firs...