Katharine M Dibb,William E Louch,Andrew W Trafford
Katharine M Dibb
In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma but also a network of membrane invaginations called transverse (t-) tubules. These structures carry the action potential deep into the cell interior, allowin...
Jose A Munoz,Anne-Catrin Uhlemann,Jonathan Barasch
Jose A Munoz
Urinary tract infection (UTI) is the most common type of urogenital disease. UTI affects the urethra, bladder, ureter, and kidney. A total of 13.3% of women, 2.3% of men, and 3.4% of children in the United States will require treatment for ...
Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling [0.03%]
跨越生命周期通过脑雌激素信号传递运行的女性电力网
Holly A Ingraham,Candice B Herber,William C Krause
Holly A Ingraham
The role of central estrogen in cognitive, metabolic, and reproductive health has long fascinated the lay public and scientists alike. In the last two decades, insight into estrogen signaling in the brain and its impact on female physiology...
Ambre M Bertholet,Yuriy Kirichok
Ambre M Bertholet
Mitochondria of all tissues convert various metabolic substrates into two forms of energy: ATP and heat. Historically, the primary focus of research in mitochondrial bioenergetics was on the mechanisms of ATP production, while mitochondrial...
Arianne Papa,Jared Kushner,Steven O Marx
Arianne Papa
Each heartbeat is initiated by the action potential, an electrical signal that depolarizes the plasma membrane and activates a cycle of calcium influx via voltage-gated calcium channels, calcium release via ryanodine receptors, and calcium ...
Geneviève Marcelin,Emmanuel L Gautier,Karine Clément
Geneviève Marcelin
Obesity is a chronic and progressive process affecting whole-body energy balance and is associated with comorbidity development. In addition to increased fat mass, obesity induces white adipose tissue (WAT) inflammation and fibrosis, leadin...
Heather N Turner,Emily R Liman
Heather N Turner
Sour taste, the taste of acids, is one of the most enigmatic of the five basic taste qualities; its function is unclear and its receptor was until recently unknown. Sour tastes are transduced in taste buds on the tongue and palate epitheliu...
Jin-Ah Park,Laura E Crotty Alexander,David C Christiani
Jin-Ah Park
The use of electronic (e)-cigarettes was initially considered a beneficial solution to conventional cigarette smoking cessation. However, paradoxically, e-cigarette use is rapidly growing among nonsmokers, including youth and young adults. ...
Derek W Russell,Kristopher R Genschmer,J Edwin Blalock
Derek W Russell
Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, smoking-related disease of significant global impact. The complex biology of COPD is ultimately driven by a few interrelated processes, including proteolytic tissue r...
Jeffrey W Brown,Charles J Cho,Jason C Mills
Jeffrey W Brown
Complex multicellular organisms have evolved specific mechanisms to replenish cells in homeostasis and during repair. Here, we discuss how emerging technologies (e.g., single-cell RNA sequencing) challenge the concept that tissue renewal is...