Alicia Mattiazzi,Donald M Bers
Alicia Mattiazzi
Calcium (Ca)/calmodulin-dependent protein kinase II (CaMKII) is a signaling molecule with critical roles in diverse cellular functions, particularly in the brain and heart, where it is highly expressed. In the heart, CaMKII regulates key pr...
Cerebrospinal Fluid-Mediated Brain Clearance: Insights from Human Studies [0.03%]
脑脊液介导的脑清除作用：来自人类研究的新见解
Per Kristian Eide,Cesar Luis Vera Quesada,Geir Ringstad
Per Kristian Eide
Clearance of waste products from brain metabolism and by-products of brain injury is a fundamental aspect of normal brain function. Impaired clearance may cause accumulation of proteins and other substances that are harmful to the brain. Ab...
The Physiological Challenge of Climate Change for Free-Living Terrestrial Mammals [0.03%]
全球变化对陆地哺乳动物生理学的挑战
Andrea Fuller,Duncan Mitchell,Shane K Maloney
Andrea Fuller
Most scenarios that seek to predict the responses of terrestrial mammals to climate change focus on the direct thermal effects of higher ambient temperatures. Measurements from free-living mammals reveal that the physiological challenge for...
Elena Oancea,Ramses Nestor
Elena Oancea
Life on earth evolved under daily cycles of sunlight, and all species developed mechanisms for detecting and responding to solar wavelengths reaching the surface of the earth. Early phototransduction studies found that our eyes detect visib...
From Oil Spills to Air Pollution: The Emergence of Phenanthrene as a Ubiquitous Cardiac Toxicant [0.03%]
从石油泄漏到空气污染：苊烯作为普遍心脏毒物的出现
Holly A Shiels
Holly A Shiels
Polycyclic aromatic hydrocarbons (PAHs) are released into the environment primarily through industrial processes and the incomplete combustion of organic matter. Their persistence in air, water, and soil facilitates widespread environmental...
Lorenzo Fabrizi,Maria Fitzgerald
Lorenzo Fabrizi
Pain is a fundamental human experience, but how does it begin? Noxious stimuli elicit strong behavioral and physiological responses, even in the youngest newborns, reflecting early subcortical engagement, but the actual experience of pain r...
Patrick A Link,Daniel J Tschumperlin
Patrick A Link
Pulmonary fibrosis is a devastating and progressive disease marked by replacement of gas-exchanging tissue with collagen-rich scar. The mechanical environment is profoundly altered in pulmonary fibrosis and contributes to disease progressio...
Decoding Connexin Hemichannels: Structure, Function, and Regulatory Mechanisms [0.03%]
连接蛋白半通道的解码：结构、功能及调节机制
Isaac E García,Jorge E Contreras
Isaac E García
Connexin hemichannels are pivotal for cellular communication, acting as independent conduits for ion and metabolite exchange, as well as precursors to gap junction channels. While their involvement in pathophysiological conditions, includin...
Tianlu Wang,Kai Zhang,Yubin Zhou
Tianlu Wang
Optogenetics and chemogenetics have transformed how physiologists interrogate biological systems by enabling precise control over protein activity and cellular function. Optogenetics uses light-sensitive proteins for rapid and localized con...
Annika Keller
Annika Keller
Primary familial brain calcification (PFBC) is a dominantly or recessively inherited neurodegenerative disease characterized by bilateral basal ganglia calcifications. Patients affected by PFBC present with diverse motor and nonmotor sympto...