Advances in Imaging-Based Fracture Risk Assessment for Unlocking Latent Skeletal Fragility [0.03%]
基于成像的骨折风险评估的新进展：揭示潜在骨骼脆弱性
Yisak Kim,Sung Hye Kong
Yisak Kim
Purpose of Review: This review summarizes recent advancements in imaging-based fracture risk assessment utilizing routinely acquired clinical images. We explore how imaging-derived methodologies and deep learning techniqu...
Olivia X Jones,Kirsten D Kelly,Stephanie K Khoo et al.
Olivia X Jones et al.
Purpose of Review: This review explores the relationship between post-traumatic stress disorder (PTSD) and bone health, focusing on how chronic psychological stress influences skeletal integrity through neuroendocrine, im...
Steven Sims,Fazilet Sen,Funda Korkmaz et al.
Steven Sims et al.
Deep Learning for Analysis of Bone Marrow Adiposity: Breakthroughs from Recent Large-Scale Analyses in the UK Biobank [0.03%]
深度学习在骨髓脂肪分析中的应用：英国生物银行近期大规模分析的突破性进展
Wei Xu,Chengjia Wang,William P Cawthorn
Wei Xu
Purpose of Review: Bone marrow adipose tissue (BMAT) is a significant fat depot with distinct skeletal, haematological and metabolic roles. It increases with ageing, osteoporosis, metabolic disease, and cancer, and is eme...
Immune Checkpoint Inhibitors and Bone Health: Mechanisms, Clinical Implications, and Emerging Perspectives on Bone Fragility [0.03%]
免疫检查点抑制剂与骨骼健康：机制、临床意义及骨质疏松新观点
Muhammed Emin Bedir,Abdulhadi Cihangir Uguz,Ismail Beypinar et al.
Muhammed Emin Bedir et al.
Purpose of Review: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but their effects on the skeletal system, independent of the influence of bone metastases, are not fully understood. This critic...
Renee T Ormsby,Claire M Edwards
Renee T Ormsby
Purpose of review: This review highlights recent studies that investigate the metabolic reprogramming that occurs in specific types of bone metastatic cancers, including different types of breast cancer, prostate cancer a...
Lithium and the Brain-Bone Axis: A Bridge between Osteoporosis and Alzheimer's Disease [0.03%]
锂与脑骨轴：骨质疏松症和阿尔茨海默病之间的桥梁
Ji-Won Lee,Tomoka Hasegawa,Aoi Ikedo et al.
Ji-Won Lee et al.
Purpose of review: We evaluate the converging evidence positioning lithium as a systemic modulator of bone and brain health through shared molecular pathways. This review examines the molecular basis, preclinical data, an...
Kavishadhi Chandrasekaran,Sitao Hu,Kara Farstad-O&#x;Halloran et al.
Kavishadhi Chandrasekaran et al.
Purpose of review: This review aims to highlight the emerging concept that nutrients and metabolites act not merely as energy sources or biosynthetic precursors, but also as instructive signalling molecules in osteoclasts...
Noah Fine,Jason S Rockel,Mohit Kapoor
Noah Fine
Purpose of review: This review article summarizes progress made using transcriptomics, in particular RNA-seq studies such as bulk, single cell (sc) and spatial sequencing results, in the study of bone and cartilage in the...
Xiaoling Zheng,Zhangsheng Dai,Kaibin Fang
Xiaoling Zheng