Pathology associated with human CAR T cell administration in NOD.Cg- PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice: A retrospective analysis [0.03%]
人源CAR-T细胞输注相关的小鼠病理改变：回顾性分析
Renata M Mammone,Elinor Willis,Pedro Ruivo et al.
Renata M Mammone et al.
Chimeric antigen receptor (CAR) T-cell therapy is a promising treatment for neoplasia and autoimmune diseases. Immunocompromised mice are a common model to test the efficacy and safety of CAR T cells of human origin. Preclinical toxicity as...
A comprehensive review of humanized mice applications in regulatory submissions for cell and gene therapy products [0.03%]
人源化小鼠在细胞和基因治疗产品监管申报中的应用综述
Giovanni Pellegrini,Lucia Minoli,Sara Degl&#x;Innocenti et al.
Giovanni Pellegrini et al.
The emergence of cell and gene therapies has transformed the therapeutic landscape, offering curative potential for a range of previously intractable diseases. However, their biological complexity and patient-specific mechanisms of action p...
Cutaneous malignant melanomas in pet rabbits (Oryctolagus cuniculus): Histological and immunohistochemical characteristics and prognostic factors [0.03%]
家兔(Oryctolagus cuniculus)皮肤恶性黑色素瘤的组织病理学和免疫组化特征及预后因素
Hirotaka Kondo,Taiki Kondo,Atsuya Takekubo et al.
Hirotaka Kondo et al.
Cutaneous malignant melanomas from 81 rabbits were retrospectively evaluated, and 51 cases were re-examined to elucidate their histopathological and immunohistochemical characteristics and to identify potential associated prognostic factors...
Development and implementation of a data parsing protocol for companion animal cancer data [0.03%]
伴侣动物癌症数据解析协议的开发与实施
Chiara Palmieri,Matt Taylor,Mike Rickerby et al.
Chiara Palmieri et al.
Companion animal cancer diagnostic reports are text-based documents containing essential information on tumor classification and diagnosis. Establishing an animal cancer registry requires integrating and extracting structured data from dive...
Morphological characterization of a novel model of steatohepatitis in the FAH-/- pig [0.03%]
FAH基因敲除猪新生仔猪NASH模型的病理特征研究
Silvana N Wilken,Philipp Felgendreff,Anna Minshew et al.
Silvana N Wilken et al.
Metabolic dysfunction-associated steatohepatitis (MASH) is a global health care burden. Appropriate large animal models mimicking the main MASH characteristics of steatosis, inflammation, and hepatocyte damage alongside progression of fibro...
Spontaneous ovarian epithelial neoplasms in guinea pigs (Cavia porcellus) [0.03%]
Guinea猪(Cavia porcellus)的卵巢上皮肿瘤自发生成
Emily K Swan,Robert A Foster,Michael M Garner et al.
Emily K Swan et al.
Diagnosis and classification of ovarian epithelial neoplasms in guinea pigs (Cavia porcellus) are challenging due to inconsistent terminology and few available diagnostic criteria. This study evaluated 23 ovarian epithelial neoplasms in 15 ...
Characterization of tumor-associated macrophages in canine soft tissue sarcomas reveals histotype-dependent immune microenvironments and correlations with mitotic count and histological grade [0.03%]
犬软组织肉瘤相关巨噬细胞的特征鉴定揭示了基于谱系的不同免疫微环境及与有丝分裂计数和组织学分级的相关性
Giancarlo Avallone,Elena Brigandì,Antonella Rigillo et al.
Giancarlo Avallone et al.
The tumor-immune microenvironment (TIME) plays a pivotal role in cancer progression, yet its characterization in veterinary oncology remains limited. Eighty-five soft tissue sarcomas (STSs), comprising fibrosarcomas, leiomyosarcomas, liposa...
Analysis of histologic patterns of dermatitis in cattle in the diagnostic process [0.03%]
皮肤病诊断过程中的牛皮炎组织学模式分析
Stella Maris P Melo,Igor R Santos,Carolina B Brunner et al.
Stella Maris P Melo et al.
The histologic diagnosis of some cases of bovine dermatitis can be challenging. We investigated the predominant histologic patterns of dermatitis in cattle, to propose histologic pattern analysis as a diagnostic approach. Sixty-two cases of...
Immunohistochemical expression of ΔNp63 versus pan-p63 in normal and neoplastic feline tissues [0.03%]
正常和肿瘤性猫组织中ΔNp63与泛p63的免疫组化表达
Igor R Santos,Carolina B Brunner,Milena C Paz et al.
Igor R Santos et al.
ΔNp63 is an isoform of p63 that plays an essential role in the development and growth of some epithelial tissues. In this study, we investigated the expression of ΔNp63 in normal and neoplastic tissues of cats and compared the results wit...
Spontaneous and experimentally induced lesions in NOD-scid gamma and other NOD-derived mouse strains [0.03%]
NOD-scid gamma及其他NOD衍生小鼠品系的自发和实验性损伤
Pedro Ruivo,Renata Mammone,Ileana Miranda et al.
Pedro Ruivo et al.
Immunodeficient mice, particularly the NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) strain and other non-obese diabetic (NOD)-derived lines are widely used in biomedical research due to their profound immunosuppression, which enables stable engraf...