Gingival Fibroblast-Driven Osteoimmunology via the IL-33-ILC2-IL-13 Axis [0.03%]
牙龈纤维母细胞介导的通过IL-33-ILC2-IL-13轴的骨免疫学效应
Y Sato,T Kondo,K Otake et al.
Y Sato et al.
Tooth extraction is a fundamental dental intervention for managing oral infections; however, the resulting tooth loss is associated with systemic health risks, including cognitive decline and increased mortality. Alveolar bone resorption fo...
L D Rock,S M Balaji,H Benzian et al.
L D Rock et al.
National oral health research strategies (NOHRSs) are increasingly recognized as critical mechanisms for aligning oral health research with public health needs, strengthening health systems, and advancing the World Health Organization's (WH...
YAP/TAZ Drive Oral Leukoplakia Progression and Confer Ferroptosis Vulnerability [0.03%]
YAP/TAZ促进口腔 leukoplakia 进展并赋予铁死亡敏感性
D Yang,L Zhang,T Zhou et al.
D Yang et al.
Oral leukoplakia (OLK), the most common potentially malignant oral disorder, poses a persistent clinical challenge due to high recurrence and malignant transformation rates, with no curative treatment currently available. Conventional inter...
Multiancestral GWAS of Dental Malocclusion Identifies Multiple Risk Loci [0.03%]
多祖先错牙合 genome-wide关联研究鉴定多个风险位点
A Alade,J M Maurer,J Anderton et al.
A Alade et al.
Malocclusion is a common oral health problem with a strong hereditary component. Previous genetic studies were limited by small sample sizes and low genomic coverage. To address these limitations, we conducted a genome-wide association stud...
H Jang,J Im,D-S Lee et al.
H Jang et al.
Periodontitis is a chronic inflammatory disease characterized by persistent inflammation, redox imbalance, and mitochondrial dysfunction, leading to progressive impairment of periodontal cellular function and tissue integrity. Current perio...
HED-Derived iPSCs Reveal Neurofunctional Defects in Ectodermal Dysplasia [0.03%]
HED源的诱导多能干细胞揭示了外胚层发育不全的神经功能缺陷
L Peng,X Song,Y Lin et al.
L Peng et al.
Ectodermal dysplasia (ED) is characterized by sparse hair, reduced sweat gland secretion, and congenital absence of teeth. While genes such as EDA and EDAR have been identified as causative factors of ED, the underlying mechanisms remain un...
P Ahmad,N E Estrin,R J Miron
P Ahmad
The regeneration of orodental and craniofacial tissues remains a primary clinical challenge owing to the requirement of harmonized integration of hard-soft tissues, immune modulation, neurogenesis, angiogenesis, and osteogenesis. Extracellu...
R Mai,X Li,X Yang et al.
R Mai et al.
The long-term success of dental implants depends critically on osseointegration and peri-implant tissue health. While local factors have been extensively investigated, the influence of systemic metabolic disorders-particularly hyperlipidemi...