Anti-EGFR Aptamer-Conjugated Erythrocyte Membrane-Derived Nanoparticles for Targeted Doxorubicin Delivery [0.03%]
抗EGFR aptamer结合红细胞膜衍生的纳米颗粒用于靶向阿霉素输送
Do Hyun Lee,Kangchan Choi,Ji Won Lee et al.
Do Hyun Lee et al.
Conventional nanomedicines frequently suffer from rapid systemic clearance via the mononuclear phagocytic system (MPS) and off-targeting, which severely limits their therapeutic index. Recently, new attempts using cell membrane-derived nano...
Influence of the Binding Valency of Anti-HER2 Biparatopic Antibodies on Biodistribution in an SK-OV-3 Tumor Xenograft Model [0.03%]
二价抗HER2双臂抗体的结合价对SK-OV-3肿瘤异种移植模型体内分布的影响
Hiroki Akiba,Kazuma Nakashima,Takayoshi Ichinose et al.
Hiroki Akiba et al.
Biparatopic antibodies (BpAbs) are an attractive format of engineered therapeutic antibodies that bind to two distinct epitopes of a single antigen. Accelerated cell internalization is anticipated in many developmental campaigns, and both b...
Lipid Nanoparticle-Mediated Delivery of 27-Hydroxycholesterol for Targeting Rhinovirus-Induced Respiratory Diseases [0.03%]
利用脂质纳米颗粒介导的27-羟基胆固醇传递靶向呼吸道病毒引起的呼吸系统疾病
Mathieu Repellin,Matteo Costantino,Rachele Francese et al.
Mathieu Repellin et al.
Human rhinovirus (HRV) is a highly widespread pathogen, the most frequent cause of the common cold, and often associated with asthma exacerbation. To date, attempts to develop direct-acting antivirals (DAAs) have proved unsuccessful, also d...
Covalent Radiopharmaceuticals: Precision Imaging and Therapy for Cancer [0.03%]
共价放射性药物在癌症精确诊断和治疗中的应用
Paul C Klauser,Lei Wang
Paul C Klauser
Covalent radiopharmaceuticals are emerging as a powerful new class of agents for cancer imaging and therapy, offering durable target engagement that overcomes the key limitations of conventional, reversible tracers. By forming covalent bond...
Investigating the Relationship between In Vitro and In Vivo Performance: The Role of Drug Loading, Release Rate, and Surface Area [0.03%]
体外和体内性能关系的研究：载药量、释放速率和表面积的作用
Emily G Benson,Hitesh S Purohit,Geoff G Z Zhang et al.
Emily G Benson et al.
Amorphous solid dispersions (ASDs) are a commonly used formulation approach for poorly water-soluble drugs to enhance release rates, generate supersaturated solutions, and improve oral absorption. Hypromellose (HPMC) has been used in commer...
Rational Selection of Chelators for Theranostic Radionuclides: Insights from Ab Initio Computational Modeling [0.03%]
基于第一性原理计算模型的放射性医用同位素药物配体的理性选择
Jeongyun Kim,Ku Kang,Kihyun Shin et al.
Jeongyun Kim et al.
Targeted radionuclide therapy (TRT) has emerged as a promising strategy for cancer treatment. While TRT offers potent therapeutic efficacy, its clinical application requires careful control due to the risk of systemic toxicity arising from ...
Cytidinyl/Cationic Lipids-siRNA Delivery Silences MYC to Reprogram Macrophages and Circadian Rhythm for Cancer Treatment [0.03%]
递送胞苷酸/阳离子脂质-siRNA以沉默MYC基因来重新编程巨噬细胞和生物钟节律以治疗癌症
Xinyang Zhou,Xiaotong Yu,Kaidi Qiu et al.
Xinyang Zhou et al.
Nonsmall cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with MYC oncogene overexpression driving tumor progression and immunosuppression. MYC has been deemed "undruggable" for a long period, and the impact of ...
Small Activating RNAs: Delivery and Therapeutic Applications in Disease Treatment [0.03%]
小型激活RNA：传递及疾病治疗中的应用
Herath Mudiyanselage Pramod Theekshana,Luyun Ni,Yuxin Zhong et al.
Herath Mudiyanselage Pramod Theekshana et al.
Over time, RNA oligonucleotides have emerged as critical tools in the field of drug discovery, offering potential therapeutic strategies for various diseases that are considered undruggable by conventional methods. Small activating RNAs (sa...
Development of a Sustainable In Situ Gel System for Ocular Delivery of p-Coumaric Acid for Corneal Wound Healing [0.03%]
一种用于角膜伤口愈合的对羟基苯甲酸眼用原位凝胶递送系统的开发研究
Subramanyam Polopalli,Achintya Saha,Pakter Niri et al.
Subramanyam Polopalli et al.
Corneal injuries are a leading cause of vision impairment, yet current therapies provide limited benefit due to poor ocular bioavailability and rapid drug clearance. To address this challenge, we developed a pH-sensitive in situ gel of p-co...
Dissolving Microneedles Loaded with Lipid Nanocarriers for Vaginal Delivery of Clotrimazole: In Vitro and Ex Vivo Evaluation [0.03%]
载有脂质纳米载体的凝胶生成型载剂溶解微针给药克霉唑：体外及皮下给药评价
Paarkavi Udayakumar,Nataša Škalko-Basnet,Veronica Rondahl et al.
Paarkavi Udayakumar et al.
Vaginal yeast infections, such as vulvovaginal candidiasis (VVC), affect nearly three out of four women worldwide. Reoccurrence is frequent and requires repeated treatments with oral, antifungal medications at high doses. Prolonged treatmen...