EGFR-Targeted and MMP-Activated Membranolytic Peptides Kill Cancer Cells Specifically In Vitro and Reduce Tumor Growth In Vivo [0.03%]
针对EGFR的MMP激活的溶膜肽能够特异性地杀死癌细胞并抑制肿瘤生长
Arindam Pramanik,Andrew Booth,Dagmara Kobza et al.
Arindam Pramanik et al.
Membranolytic peptides are potential cancer therapeutics, although targeting cancer cells specifically remains an unmet challenge. We have modified the membranolytic peptide MP1, from Polybia paulista, to direct its action specifically to s...
Anticancer Efficacy of HPPH-PDT Synergies with BCG-Immunotherapy or COX-2 Inhibitor in Treating Bladder Cancer [0.03%]
BCG免疫治疗或COX-2抑制剂联合光动力治疗膀胱癌的作用研究
Farukh A Durrani,Joseph Cacaccio,William Potter et al.
Farukh A Durrani et al.
Among the photosensitizers (PSs) developed in our laboratory, 3-(1'-hexyloxy) ethyl-3-devinyl pyropheophorbide-a (HPPH) is undergoing Phase-II multicenter clinical trials for the treatment of head and neck and esophageal cancers. The PS exh...
Correction to "Endplate Chondrocyte Derived Exosomal miR-133a-3p Alleviates Intervertebral Disc Degeneration by Targeting the NF-κB Signaling Pathway through the miR-133a-3p/MAML1 Axis" [0.03%]
题为“终板软骨细胞源性外泌体miR-133a-3p通过miR-133a-3p/MAML1轴靶向NF-κB信号通路缓解椎间盘退变”的更正通知
Qiuwei Li,Ruocheng Guo,Chenhao Zhao et al.
Qiuwei Li et al.
Published Erratum
Molecular pharmaceutics. 2026 Mar 31. DOI:10.1021/acs.molpharmaceut.6c00351 2026
Polygonatum sibiricum Polysaccharide and αGalCer Synergistically Act as Dual Adjuvants to Enhance Humoral and Cellular Immune Responses [0.03%]
Polygonatum sibiricum多糖和α-GalCer作为双佐剂协同增强体液免疫和细胞免疫响应
Jingwen Liu,Jian Wang,Yuancong He et al.
Jingwen Liu et al.
Adjuvants are indispensable for subunit vaccines. However, the development of safe and effective adjuvants remains a major challenge. Polysaccharides derived from traditional Chinese medicine (TCM) have recently emerged as promising sources...
Evolution of Particle Radiotherapy: From Physical to Dual Targeting in Precision Medicine [0.03%]
粒子放射治疗的发展：从物理到精准医疗中的双重靶向疗法
Heying Yao,Fan Zheng,Yan Zhong et al.
Heying Yao et al.
As cancer remains a formidable global health challenge, radiotherapy is evolving toward unprecedented levels of precision. Particle radiotherapy (PRT), utilizing charged particles such as protons and carbon ions, has emerged as a superior a...
Advanced Age-Related Changes in Intestinal Drug Transporters and Metabolising Enzymes: A Targeted Proteomics Study [0.03%]
肠道药物转运体和代谢酶的年龄相关变化：靶向蛋白组学研究
Fritz Harder,Joachim Brouwers,Tim Vanuytsel et al.
Fritz Harder et al.
This study examines the influence of aging on the protein abundance of key drug transport proteins (DTPs) and drug-metabolizing enzymes (DMEs). Duodenal and colonic biopsies were collected from 58 volunteers aged 19-85 years who underwent r...
Cationic Nanogel Coated Norovirus VLP Nasal Vaccine Induces Neutralizing Mucosal IgA and Serum IgG Antibodies [0.03%]
阳离子纳米凝胶包被的诺如病毒样颗粒鼻粘膜疫苗可诱导产生中和性分泌型IgA及血清IgG抗体
Yoshikazu Yuki,Shiho Kurokawa,Tomoyuki Yamanoue et al.
Yoshikazu Yuki et al.
Although norovirus can affect people of any age, the majority of deaths and illnesses occur in children under one year old and people over the age of 55. Currently, there is no vaccine or medication available. Previously, we developed a nas...
Yahya E Choonara,Kelly Chibale,Martin Thuo et al.
Yahya E Choonara et al.
Covalent versus Dimeric Optimization of Nectin-4-Targeted Peptide Radiotracers: A Head-to-Head Comparison in Triple-Negative Breast Cancer Mice Models [0.03%]
靶向nectin-4的肽放射性示踪剂的共价与二聚类优化：三阴性乳腺癌小鼠模型中的头对头比较研究
Yang Pei,Xu Zhou,Fei Gao et al.
Yang Pei et al.
Nectin-4 is highly expressed in several malignancies, including triple-negative breast cancer, and it represents an attractive target for molecular imaging and therapy. In this study, we report the first head-to-head comparison of two struc...
Comparative Study
Molecular pharmaceutics. 2026 Apr 6;23(4):2693-2703. DOI:10.1021/acs.molpharmaceut.5c01816 2026
Addressing the Release and Permeation Challenges of High- Tg Drugs in Amorphous Solid Dispersions [0.03%]
高Tg药物在无定形固体分散体中释放和渗透的挑战及解决方案
Dishan D Shah,Zhuangyan Xu,Gregory T Knipp et al.
Dishan D Shah et al.
The goal of the current study was to assess the release rate of model high glass transition temperature (Tg) drugs from amorphous solid dispersions (ASDs) as a function of drug loading, and then to evaluate the permeation rate of the result...