Novel Gold-Functionalization of Liposomes and Its Impact on Cellular Uptake and Trafficking [0.03%]
新型金包被脂质体的制备及其对细胞摄取和内吞途径的影响研究
Agata Margielewska,Klaudia Łuków,Abdelatif Laroui et al.
Agata Margielewska et al.
Liposomes decorated with gold nanoparticles (AuNPs) represent multifunctional nanocarriers that combine high drug-loading capacity with the unique physicochemical properties of metallic nanoparticles. Here, we report a simple one-pot strate...
Chunxu Cao,Huirong Nie,Jingxuan Zhu et al.
Chunxu Cao et al.
Neuroendocrine neoplasms (NENs) are rare clinical entities that have long posed significant challenges in diagnosis and treatment due to their high histological heterogeneity, a scarcity of effective therapeutic targets, and consequently, l...
Sustained Release of Carvacrol Aldehyde from Hydroxyapatite for Osteosarcoma Inhibition [0.03%]
从羟基磷灰石中持续释放愈创香醛抑制骨肉瘤
Aditi Dahiya,Susmita Bose
Aditi Dahiya
The clinical management of bone cancer and infections remains a critical challenge due to limitations in localized drug delivery and rising antibiotic resistance. In our previous studies, we demonstrated carvacrol's (CA) osteogenic and anti...
Spectroscopic and Thermodynamic Exploration of Folic Acid's Modulatory Impact on the Bimolecular Interactions of Hemoglobin with Pemetrexed [0.03%]
叶酸对血红蛋白与培美曲塞双分子相互作用调控的光谱及热力学研究
Srinuvasu Nakka,Rashmi Prabha,Deepak Chahar et al.
Srinuvasu Nakka et al.
Pemetrexed (PEM) disrupts folate metabolism and may lead to blood-related side effects, such as anemia. Folic acid (FA) supplementation can be beneficial in reducing anemia caused by pemetrexed, as it helps replenish folate levels. FA plays...
Downstream-Induced Destabilization of Neat Amorphous Drugs: Implications on Solid-State Stability and Performance [0.03%]
下游因素引起的无定型药物的不稳定性：固态稳定性和性能的影响
Ioannis Pantazos,Afroditi Kapourani,Sofia Katsiadaki et al.
Ioannis Pantazos et al.
Amorphous drug formulations offer a powerful strategy for enhancing the apparent solubility and bioavailability of poorly water-soluble drugs. However, their inherent physical instability, particularly the tendency to recrystallize during d...
Encapsulation of Glucose Oxidase in Porous Cu(II)-Doped Zinc Phosphate@polydopamine Nanoparticles for Triple-Combination Therapy of Cancer [0.03%]
基于多巴胺的Cu(II)掺杂多孔聚磷酸锌纳米粒子封装葡萄糖氧化酶用于癌症三结合疗法
Mengxiao Fan,Xiang Wen,Jing Zhang et al.
Mengxiao Fan et al.
Designing multifunctional nanotherapeutic platforms that integrate multiple therapeutic capabilities with enhanced tumor specificity and low systemic toxicity has emerged as a promising strategy for cancer therapy. Herein, we put forward a ...
Correction to "Development of Novel Peptide-Based 68Ga-Labeled Radiotracers for Detecting ROR1 Expression in Tumors" [0.03%]
“新型肽基68镓放射性示踪剂的开发用于检测肿瘤中的ROR1表达”的纠正评论文章
Shuhui Huang,Tian Tian,Mengfang Qi et al.
Shuhui Huang et al.
Published Erratum
Molecular pharmaceutics. 2026 Apr 6. DOI:10.1021/acs.molpharmaceut.6c00406 2026
Formulation Screening of Lipid Nanoparticles Enhances mRNA Delivery to Retina [0.03%]
脂质纳米颗粒的配方筛选可增强mRNA向视网膜的递送
Jin Yu,Zesen Ma,Haiyang Tong et al.
Jin Yu et al.
Inherited retinal diseases (IRDs) are a group of genetically heterogeneous neurodegenerative disorders that cause progressive vision loss. Gene therapies based on adeno-associated virus vectors have achieved notable progress in IRDs, but th...
Development and Preclinical Evaluation of a Selinexor-Derived Radiotracer [68Ga]Ga-NOTA-Selinexor for Imaging XPO1 Expression in Multiple Myeloma [0.03%]
一种用于检测多发性骨髓瘤中XPO1表达的放射示踪剂[68Ga]Ga-NOTA-塞利努克斯的开发和临床前评估
Xinlin Zhong,Junjie Yan,Chen Su et al.
Xinlin Zhong et al.
Selinexor, an FDA-approved XPO1 inhibitor for relapsed or refractory multiple myeloma (MM), has been explored as a precursor for isotopologically 18F-labeling to enable PET imaging of XPO1 expression in MM. However, low tumor-to-muscle (T/M...
Injected Eye, Fellow Eye and Systemic Pharmacokinetic Modeling of Intravitreally Administered Bevacizumab [0.03%]
玻璃体内注射贝伐单抗的眼内及全身药动学系统模型研究
Maria Franz,Ravi Kumar Jairam,Guangda Ma et al.
Maria Franz et al.
Simulation of retinal drug concentrations after intravitreal administration is still challenging, due to knowledge gaps in ocular physiology such as the molecule-dependent permeability of ocular segments and the mechanisms determining a dru...