Effect of Drug-Polymer Interaction on Solid-State Stability and In Vitro Drug Flux of Amorphous Solid Dispersions [0.03%]
药物-聚合物相互作用对固态稳定性及无定形固体分散体中载药量的影响
N S Krishna Kumar,Corinne Jankovsky,Ewa Zimny et al.
N S Krishna Kumar et al.
Polymers play a pivotal role in amorphous solid dispersion (ASD) formulations. An ideal polymer must possess several attributes: it must maintain solid-state stability (retention of drug in the amorphous state), sustain the drug in a supers...
Facile Fabrication of Multifunctional Metal-Phenolic Network Nanoparticles for Bacterial Keratitis Treatment [0.03%]
用于细菌性角膜炎治疗的多功能金属-酚网络纳米粒子的简易制备方法
Mengting Wang,Chen Qin,Yajia Wang et al.
Mengting Wang et al.
The management of methicillin-resistant Staphylococcus aureus (MRSA) keratitis remains highly challenging due to escalating antibiotic resistance and the severe, vision-threatening damage driven by uncontrolled inflammation. In this work, E...
mRNASyner: An Integrative Framework for Full-Length mRNA Sequence Optimization via Multimodule Synergistic Design [0.03%]
mRNASyner：一种通过多模块协同设计优化全长mRNA序列的综合框架
Zijie Gu,Gang-Ao Wang,Ziyan Feng et al.
Zijie Gu et al.
Messenger RNA (mRNA) technology holds great promise in biomedicine; however, its therapeutic efficacy relies heavily on translation efficiency and the in vivo stability of mRNA sequences, both of which are governed by dynamic interactions b...
Development of Liposomal Formulations Composed of Thermoresponsive Polymers to Enhance Tumor Accumulation in Combining with Local Tumor Heating [0.03%]
基于热致响应聚合物的脂质体递药系统设计及其与局部肿瘤加热协同提高肿瘤蓄积效应的研究
Tomoya Fukada,Kohei Sano,Momoka Nakata et al.
Tomoya Fukada et al.
Liposomes, nanosized vesicles consisting of a lipid bilayer membrane, have been widely investigated as versatile drug delivery systems. Clinically, several liposomal formulations have been used as anticancer drug carriers owing to their enh...
Parallel-Competitive Absorption-Presystemic Metabolism Model for Subcutaneous Bioavailability Prediction of Monoclonal Antibodies [0.03%]
用于预测单克隆抗体皮下生物利用度的并行竞争吸收-药物转运体代谢模型
Mikolaj Milewski,Maria A Cueto,Mikhail Murashov et al.
Mikolaj Milewski et al.
Monoclonal antibody therapeutics are often administered subcutaneously rather than intravenously to improve patient compliance and reduce healthcare costs. However, systemic absorption after a subcutaneous injection is often incomplete and ...
Targeting of VISTA with Cyclic Peptide-Based PET Tracers for Immune Checkpoint Imaging [0.03%]
基于环肽的正电子发射断层显像剂靶向VISTA用于免疫检查点成像
Han Feng,Xiaoting Tian,Xiaofei Li et al.
Han Feng et al.
Given the distinct roles of VISTA in immune regulation, a better visualization of VISTA expression could clarify the tumor immune status and predict the responses to immunotherapy. However, only a few targeted probes are in development and ...
Biotin-Decorated Inulin-Based Polymeric Micelles Unveil Their Dual-Targeting Ability for the Potential Treatment of Glioblastoma Multiforme through the In Vitro and In Vivo Investigations [0.03%]
基于藻糖的聚丙烯酸微米粒揭示其双靶向能力通过体内外实验探究其潜在治疗多形性胶质母细胞瘤的能力
Paola Riccobelli,Elena Cannone,Serena Filiberti et al.
Paola Riccobelli et al.
This study evaluated biotinylated-inulin vitamin E micelles (INVITE-BIO) as a carrier for the hydrophobic drug curcumin and their biotin-mediated dual-targeting ability to the Blood-Brain Barrier (BBB) and Glioblastoma Multiforme (GBM) cell...
Ionizable Polymeric Micelles Targeting Transferrin Receptor 1 Enhance Systemic mRNA Delivery to the Brain [0.03%]
一种靶向转铁蛋白受体1的可离子化聚合物胶束，可增强脑部系统的mRNA递送
Jumpei Norimatsu,Hayato L Mizuno,Yuki Mochida et al.
Jumpei Norimatsu et al.
mRNA-based therapies hold immense potential for treating a plethora of diseases. However, their application to central nervous system (CNS) disorders remains limited due to biological barriers, such as rapid degradation in circulation, rest...
g-C3N4 Nanosheets as a Ferroptosis-Targeted Nanoprobe: Mitigating Iron Overload and Restoring Male Fertility via Nrf2 Pathway Activation [0.03%]
以g-C3N4纳米片为铁死亡靶向纳米探针通过激活Nrf2通路缓解铁过载及恢复雄性生育力
Lingling Wang,Fuyu Yang,Zhixin Ye et al.
Lingling Wang et al.
Ferroptosis induced by iron overload has been recognized as a critical factor in germ cell damage and subsequent male infertility. However, current ferroptosis inhibitors are often constrained by systemic side effects and limited targeting....
Nanostructured Lipid Carriers Enhance Brain Delivery and Antioxidant Efficacy of a Small-Molecule MAO B Inhibitor for Neurodegenerative Disease Therapy [0.03%]
纳米结构脂质载体可增强小分子MAO-B抑制剂的脑传递及抗氧化功效以治疗神经退行性疾病
Rita Mastrogiacomo,Daniela Valeria Miniero,Mariagrazia Rullo et al.
Rita Mastrogiacomo et al.
Neurodegenerative disorders, including Alzheimer's and Parkinson's diseases, urgently require new therapeutic strategies. Monoamine oxidase B (MAO B), a mitochondrial enzyme involved in oxidative stress and neurotransmitter metabolism, has ...