Coarse-Grained Molecular Dynamics Simulation of Heterogeneous Polysorbate 80 Surfactants and their Interactions with Small Molecules and Proteins [0.03%]
聚山梨酯80界面吸附及其与小分子和蛋白质相互作用的粗粒化分子动力学模拟研究
Hao Lou,Yaqi Wu,Krzysztof Kuczera et al.
Hao Lou et al.
Polysorbate 80 (PS80) is widely used in pharmaceutical formulations, and its commercial grades exhibit certain levels of structural heterogeneity. The objective of this study was to apply coarse-grained molecular dynamics simulations to bet...
Development and Characterization of a Peptide-Bisphosphonate Nanoparticle for the Treatment of Breast Cancer [0.03%]
乳腺癌治疗用肽-双膦酸盐纳米粒子的开发与表征
Kimberley Glass,Cory Fines,Paula Coulter et al.
Kimberley Glass et al.
In women, breast cancer (BC) is the most common cancer, and despite advancements in diagnosis and treatment, 20-30% of early stage BC patients develop metastatic disease. Metastatic BC is deemed an incurable disease, which accounts for 90% ...
Unravelling Microarray Patch Performance: The Role of In Vitro Release Medium and Biorelevant Testing [0.03%]
微阵列贴片性能解析：体外释放介质和生物相关测试的作用
Maja Railic,Abina M Crean,Sonja Vucen
Maja Railic
The absence of established protocols for studying the in vitro performance of dissolvable microarray patches (MAPs) poses a significant challenge within the field. To overcome this challenge, it is essential to optimize testing methods in a...
Additive Manufacturing of SmartEx QD 100 Designed Oral Three-Dimensional Printlets Containing Isoniazid for Immediate Gastric Release by Selective Laser Sintering [0.03%]
选择性激光烧结法制备含有异烟肼的智能型QD 100设计口服三维打印制剂用于胃立即释放
Tukaram Karanwad,Sachin B Jorvekar,Santa Mandal et al.
Tukaram Karanwad et al.
The selection of appropriate materials and compatibility of selected materials with drugs and formulations are limiting steps in three-dimensional printing technology. In this study, SmartEx QD 100 (SM QD 100) was introduced as a novel, cop...
Imaging Pulmonary Fibrosis and Treatment Efficacy In Vivo with Autotaxin-Specific PET Ligand [18F]ATX-1905 [0.03%]
具有特异性靶向自分泌运动因子的放射性正电子发射断层显像示踪剂[18F]ATX-1905在体成像评估肺纤维化及其治疗效果研究
Xiaoyun Deng,Junyi Liu,Jianyuan Zhou et al.
Xiaoyun Deng et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by unpredictable progression and limited therapeutic options. Current diagnosis relies on high resolution computed tomography (HRCT), which may not adequately capture earl...
Acute Neuroinflammation Alters the Transport of a Model Therapeutic Protein from the Brain into Lymph and Blood [0.03%]
急性神经炎症改变模型治疗蛋白从大脑转运至淋巴和血液中通路
Thu A Hoang,Liang Jin,Joseph A Nicolazzo et al.
Thu A Hoang et al.
The drainage of fluid and solutes along lymphatic pathways from the brain has been found to be impaired in mouse models of multiple sclerosis, Alzheimer's disease, and Parkinson's disease where neuroinflammation is present. We recently demo...
Octa-Arginine-Conjugated Liposomal Nimodipine Incorporated in a Temperature-Responsive Gel for Nasoencephalic Delivery [0.03%]
用于鼻脑递送的八精氨酸修饰载尼莫地平脂质体温敏凝胶制剂
Shuai Hong,Changxiu Lin,Junsheng Hu et al.
Shuai Hong et al.
Nimodipine is the primary clinical drug used to treat cerebral vasospasm following subarachnoid hemorrhage. Currently, tablets have low bioavailability when taken orally, and injections contain ethanol. Therefore, we investigated a new meth...
Development of Alginate-Based Biodegradable Radioactive Microspheres Labeled with Positron Emitter through Click Chemistry Reaction: Stability and PET Imaging Study [0.03%]
通过点击化学反应开发基于海藻酸盐的可生物降解放射性微球及其稳定性及PET成像研究
Arun Gupta,Ji Yong Park,Hyunjun Choi et al.
Arun Gupta et al.
Biodegradable radioactive microspheres labeled with positron emitters hold significant promise for diagnostic and therapeutic applications in cancers and other diseases, including arthritis. The alginate-based polymeric microspheres offer a...
Correction to "Novel Synergistic Approach: Tazarotene-Calcipotriol-Loaded-PVA/PVP-Nanofiber Incorporated in Hydrogel Film for Management and Treatment of Psoriasis" [0.03%]
关于“用于管理和治疗银屑病的新型协同方法：负载在PVA/PVP纳米纤维中的他扎罗汀-卡泊三醇-载药水凝胶薄膜”的勘误通知
Sunita Thakur,Md Meraj Anjum,Shweta Jaiswal et al.
Sunita Thakur et al.
Published Erratum
Molecular pharmaceutics. 2024 Sep 2;21(9):4754-4756. DOI:10.1021/acs.molpharmaceut.4c00635 2024
Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion Clearance [0.03%]
白蛋白介导的有机阴离子转运蛋白1/3结合药物摄取吸收：对主动肾分泌清除预测的意义
Shawn Pei Feng Tan,Annika Tillmann,Susan J Murby et al.
Shawn Pei Feng Tan et al.
Modulation of the transport-mediated active uptake by human serum albumin (HSA) for highly protein-bound substrates has been reported and improved the in vitro-to-in vivo extrapolation (IVIVE) of hepatic clearance. However, evidence for the...