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Exosomal miR-590-3p derived from bone marrow mesenchymal stem cells promotes osteoblast differentiation and osteogenesis by targeting TGFBR1 [0.03%] 骨髓间充质干细胞衍生的外泌体miR-590-3p通过靶向TGFBR1促进成骨细胞分化和骨骼生成
Dandan Luo,Wantao Xie,Xiaoli He et al. Dandan Luo et al.
Bone marrow mesenchymal stem cells (BMSCs) have been verified to be essential factors regulating osteogenic functions, which is mainly attributed to their secretion of extracellular vesicles. Exosomes derived from BMSCs (BMSCs-Exo) contribu...
Exploring the osteogenic potential of semisynthetic triterpenes from Combretum leprosum: An in vitro and in silico study [0.03%] 半合成越桔素衍生物促骨形成作用的体外及分子对接研究
Valdo Nogueira-Júnior,Fátima Regina N Sousa,Conceição da S M Rebouças et al. Valdo Nogueira-Júnior et al.
Combretum leprosum Mart. is a plant of the Combretaceae family, widely distributed in the Northeast region of Brazil, popularly used as an anti-inflammatory agent, and rich in triterpenes. This study evaluated in vitro and in silico potenti...
Decellularized leaf-based biomaterial supports osteogenic differentiation of dental pulp mesenchymal stem cells [0.03%] 脱细胞叶基生物材料支持牙髓间充质干细胞向成骨细胞分化
Kaustubh Raundal,Avinash Kharat,Avinash Sanap et al. Kaustubh Raundal et al.
Decellularized tissues are an attractive scaffolds for 3D tissue engineering. Decellularized animal tissues have certain limitations such as the availability of tissue, high costs and ethical concerns related to the use of animal sources. P...
MiR-483-3p promotes dental pulp stem cells osteogenic differentiation via the MAPK signaling pathway by targeting ARRB2 [0.03%] microRNA-483-3p通过靶向ARRB2促进牙髓干细胞成骨分化 via MAPK信号通路
Xin Yu,Juan Ge,Huimin Xie et al. Xin Yu et al.
Human dental pulp stem cells (DPSCs) have become an important component for bone tissue engineering and regenerative medicine due to their ability to differentiate into osteoblast precursors. Two miRNA chip datasets (GSE138180 and E-MTAB-30...
Evaluating osteogenic potential of a 3D-printed bioceramic-based scaffold for critical-sized defect treatment: an in vivo and in vitro investigation [0.03%] 一种基于生物陶瓷的3D打印支架的促骨生长潜能评估：体内外研究
Hannaneh Safiaghdam,Sahar Baniameri,Hossein Aminianfar et al. Hannaneh Safiaghdam et al.
The integration of precision medicine principles into bone tissue engineering has ignited a wave of research focused on customizing intricate scaffolds through advanced 3D printing techniques. Bioceramics, known for their exceptional biocom...
Polycaprolactone/poly L-lactic acid nanofibrous scaffold improves osteogenic differentiation of the amniotic fluid-derived stem cells [0.03%] 聚ε-己内酯/聚L乳酸纳米纤维支架提高羊膜来源干细胞的成骨分化能力
Seyyedeh Masoumeh Pishnamazi,Sayyed Mohammad Hossein Ghaderian,Shiva Irani et al. Seyyedeh Masoumeh Pishnamazi et al.
Using stem cells is one of the most important determining factors in repairing lesions using regenerative medicine. Obtaining adult stem cells from patients is a perfect choice, but it is worth noting that their differentiation and prolifer...
Ubiquitination of ASCL1 mediates CD47 transcriptional activation of the AKT signaling pathway, and glycolysis promotes osteogenic differentiation of hBMSCs [0.03%] ASCL1泛素化介导CD47激活AKT信号通路及糖酵解促进人骨髓间充质干细胞成骨分化
Jimei Zhang,Ling Zhu,Jianping Zhou et al. Jimei Zhang et al.
Bones are extremely dynamic organs that continually develop and remodel. This process involves changes in numerous gene expressions. hBMSC cells can promote osteogenic differentiation. The purpose of this study was to elucidate the mechanis...
Effects of vitamin A in promoting proliferation and osteogenic differentiation of human periodontal ligament cells [0.03%] 维生素A通过促进人牙周膜细胞增殖和成骨分化的作用促进牙周组织再生
Jing Wang,Zhaobao Li Jing Wang
Human periodontal ligament cells (hPDLCs) are known as ideal seed cells for the regeneration of periodontal tissues. Several factors (i.e., vitamin D3, luteolin, and 6-bromoindirubin-3'-oxime) have been shown to promote osteogenic different...
microRNA-29b-3p/sirtuin-1/peroxisome proliferator-activated receptor γ suppress osteogenic differentiation [0.03%] miR-29b-3p/SIRT1/PPARγ抑制成骨分化
Huanxin Xie,Lei Cao,Linlin Ye et al. Huanxin Xie et al.
Osteoporosis is described as an age-associated impairment of bone formation. microRNA (miR)-29b-3p was thought to be linked to osteoblast differentiation; however, the underlying molecular pathways are yet unknown. The study's goal was to l...
SOX2 suppresses osteoblast differentiation of MC3T3-E1 cells through activating the transcription of LGR4 [0.03%] SOX2通过激活LGR4的转录来抑制MC3T3-E1细胞的成骨分化
Sunyu Chen,Zhanhao Xiao,Wenjin Jiang Sunyu Chen
Osteogenic differentiation is a crucial process of new bone formation. This study aimed to explore the roles and mechanism of SRY-Box Transcription Factor 2 (SOX2) on proliferation and osteogenic differentiation of MC3T3-E1 cells. Bone morp...