A phlorotannin-rich seaweed extract activates AMPK/PGC-1α signaling and antioxidant defences in skeletal muscle cells [0.03%]
一种富含褐藻素的海带提取物可激活骨骼肌细胞中的AMPK/PGC-1α信号通路和抗氧化防御功能
Anaïs Marandeau,Morgane Pengam,Solène Connan et al.
Anaïs Marandeau et al.
Sedentary behaviour, ageing and chronic diseases represent major public health burdens associated with impaired skeletal muscle function and increased oxidative stress. Identifying bioactive compounds capable of mimicking the molecular adap...
E3 ubiquitin ligase SYVN1 promotes the malignant phenotype of A549 cells by upregulating GATA3 expression via NRP1 [0.03%]
E3连接酶SYVN1通过NRP1上调GATA3表达促进A549细胞恶性表型
Shan Wang,Suli Lu,Zhen Wang et al.
Shan Wang et al.
Lung cancer remains one of the most lethal and prevalent malignancies worldwide. Although E3 ubiquitin ligase SYVN1 is frequently amplified in lung cancer, its functional role has not been fully elucidated. This study investigates the mecha...
Establishment of a stable three-dimensional fibrotic cell culture model for reproducible baseline and experimental applications [0.03%]
建立稳定的三维细胞纤维化模型用于基线和实验研究
Ayse Kocak-Sezgin,Elif Aydin,Meliha Koldemir-Gündüz et al.
Ayse Kocak-Sezgin et al.
Systemic sclerosis (SSc) is characterized by progressive fibrosis and complex alterations in extracellular matrix dynamics; however, experimental modeling of fibrotic processes remains limited by poor control of baseline signaling and spont...
FTO suppresses PRTN3 translation via m⁶A demethylation to block the CXCL9/CXCR3 axis and attenuate atherosclerosis [0.03%]
FTO通过去甲基化抑制PRTN3翻译，以阻断CXCL9/CXCR3轴并减轻动脉粥样硬化病情
Gulizibaer Mamuti,Buajieerguli Nasier,Aliye Ainiwa et al.
Gulizibaer Mamuti et al.
Coronary artery disease (CAD) involves intricate immune-related pathways; however, the contribution of epigenetic mechanisms remains inadequately defined. The fat mass and obesity-associated protein (FTO), which functions as an N⁶-methylad...
Quercetin, an ingredient of Jiedu Xiaozheng Yin, alleviates hepatocellular carcinoma progression by regulating CYP1A2/PTEN/PI3K/Akt axis [0.03%]
檞皮素通过调节CYP1A2/PTEN/PI3K/Akt轴缓解肝癌进展
Zhenhua Zhou,Zhenliang Xiao,Wu Wen et al.
Zhenhua Zhou et al.
Hepatocellular carcinoma (HCC) has a poor prognosis and limited treatment options. This study investigated the role and mechanism of Jiedu Xiaozheng Yin (JXY) in HCC using network pharmacology and in vivo/in vitro experiments. Active compon...
Enhancing adipogenic differentiation efficiency and gene expression in yak stromal vascular cells through 3D spheroid culture [0.03%]
三维球体培养提高牦牛基质血管细胞的成脂分化效率和基因表达水平
Yannan Ma,Lei Zheng,Pengjia He et al.
Yannan Ma et al.
Intramuscular fat deposition is a key determinant of meat quality in livestock species; however, yak (Bos grunniens) stromal vascular cells (SVCs) exhibit relatively low adipogenic differentiation efficiency under conventional in vitro cond...
Bletilla striata polysaccharide inhibits osteoclast differentiation by suppressing macrophage glycolysis and MMP9 expression [0.03%]
白及多糖通过抑制巨噬细胞糖酵解和MMP9表达抑制破骨细胞分化
Zhiya Wang,Yanjie Li,Shu Zhang et al.
Zhiya Wang et al.
Utilizing single-cell RNA sequencing and network pharmacology, this study explored the mechanism by which Bletilla striata polysaccharide (BSP) mitigates peri-implantitis-associated osteolysis. Integrated analyses revealed a significant exp...
Comparison of periapical cyst- and dental pulp-derived mesenchymal stem cells: an in vitro study on proliferation, differentiation, migration, and odontogenic potential [0.03%]
牙源性间充质干细胞的比较：关于增殖、分化、迁移和成牙本质潜力的体外研究
Burcu Pirimoğlu,Cangül Keskin,Melek Yüce et al.
Burcu Pirimoğlu et al.
The aim of this study was to isolate human periapical cyst-derived mesenchymal stem cells (PC-MSCs) and compare their immunophenotypic profiles, clonogenic capacity, metabolic activity, migration capacity, and differentiation characteristic...
Thermal stimulation promotes myogenic differentiation through enhanced glucose uptake and transient lipid droplet accumulation in C2C12 cells [0.03%]
热刺激通过增强葡萄糖摄取和瞬时脂滴积累促进C2C12细胞肌源性分化
Rumana Mahzabin,Satoko Hayashi,Md Rezwanul Habib et al.
Rumana Mahzabin et al.
Mild thermal stimulation enhances skeletal muscle differentiation; however, its underlying metabolic basis remains unclear. Here, we demonstrate that thermal stimulation promotes myogenic differentiation through enhanced glucose uptake and ...