Quercetin, an ingredient of Jiedu Xiaozheng Yin, alleviates hepatocellular carcinoma progression by regulating CYP1A2/PTEN/PI3K/Akt axis [0.03%]
檞皮素通过调节CYP1A2/PTEN/PI3K/Akt轴缓解肝癌进展
Zhenhua Zhou,Zhenliang Xiao,Wu Wen et al.
Zhenhua Zhou et al.
Hepatocellular carcinoma (HCC) has a poor prognosis and limited treatment options. This study investigated the role and mechanism of Jiedu Xiaozheng Yin (JXY) in HCC using network pharmacology and in vivo/in vitro experiments. Active compon...
Enhancing adipogenic differentiation efficiency and gene expression in yak stromal vascular cells through 3D spheroid culture [0.03%]
三维球体培养提高牦牛基质血管细胞的成脂分化效率和基因表达水平
Yannan Ma,Lei Zheng,Pengjia He et al.
Yannan Ma et al.
Intramuscular fat deposition is a key determinant of meat quality in livestock species; however, yak (Bos grunniens) stromal vascular cells (SVCs) exhibit relatively low adipogenic differentiation efficiency under conventional in vitro cond...
Bletilla striata polysaccharide inhibits osteoclast differentiation by suppressing macrophage glycolysis and MMP9 expression [0.03%]
白及多糖通过抑制巨噬细胞糖酵解和MMP9表达抑制破骨细胞分化
Zhiya Wang,Yanjie Li,Shu Zhang et al.
Zhiya Wang et al.
Utilizing single-cell RNA sequencing and network pharmacology, this study explored the mechanism by which Bletilla striata polysaccharide (BSP) mitigates peri-implantitis-associated osteolysis. Integrated analyses revealed a significant exp...
Comparison of periapical cyst- and dental pulp-derived mesenchymal stem cells: an in vitro study on proliferation, differentiation, migration, and odontogenic potential [0.03%]
牙源性间充质干细胞的比较：关于增殖、分化、迁移和成牙本质潜力的体外研究
Burcu Pirimoğlu,Cangül Keskin,Melek Yüce et al.
Burcu Pirimoğlu et al.
The aim of this study was to isolate human periapical cyst-derived mesenchymal stem cells (PC-MSCs) and compare their immunophenotypic profiles, clonogenic capacity, metabolic activity, migration capacity, and differentiation characteristic...
Thermal stimulation promotes myogenic differentiation through enhanced glucose uptake and transient lipid droplet accumulation in C2C12 cells [0.03%]
热刺激通过增强葡萄糖摄取和瞬时脂滴积累促进C2C12细胞肌源性分化
Rumana Mahzabin,Satoko Hayashi,Md Rezwanul Habib et al.
Rumana Mahzabin et al.
Mild thermal stimulation enhances skeletal muscle differentiation; however, its underlying metabolic basis remains unclear. Here, we demonstrate that thermal stimulation promotes myogenic differentiation through enhanced glucose uptake and ...
Apigenin in TMG inhibits colorectal tumorigenesis by targeting GSK3β/APC/β-catenin signaling pathway [0.03%]
阿皮金在TMG中通过靶向GSK3β/APC/β-连环蛋白信号通路抑制结直肠肿瘤发生
Mei Li,Wei Wang,Renjing Lin et al.
Mei Li et al.
Colorectal cancer (CRC) is a malignant tumor with a high global incidence. Tianma granule (TMG) is a traditional Chinese medicine compound. However, its pharmacodynamic material basis and mechanism of action against CRC remained unclear. Th...
Role of GPCR41 silencing in conjugated linoleic acid-induced adipogenesis of bovine intramuscular preadipocytes [0.03%]
肌间前脂肪细胞中GPCR41沉默在共轭亚油酸诱导的成脂分化中的作用研究
Rong Wan,Chuanfang Zhang,Qingxiang Meng et al.
Rong Wan et al.
The present study examined the impact of conjugated linoleic acid (CLA) on the differentiation and proliferation of bovine intramuscular preadipocyte (BIP) cells, specifically exploring the role of G protein-coupled receptor 41 (GPCR41). Ce...
Paclitaxel-induced cytoskeletal and focal adhesion reorganisation alters connexin43 and α-smooth muscle actin in cardiac cells [0.03%]
紫杉醇通过重塑细胞骨架和焦粘附改变心脏细胞中的连接子43和α-平滑肌肌动蛋白
Neethu Mohan,Sruthi Radhakrishnan,Dhakshmi Sasankan et al.
Neethu Mohan et al.
Paclitaxel, a microtubule-stabilising anticancer drug, exhibits cardiotoxicity; however, the impact of microtubule stabilisation on cytoskeletal and focal adhesion proteins and their consequences on key proteins in cardiac cells remains inc...
Endothelial cell-derived microRNAs-containing extracellular vesicles and diabetic retinopathy in a mouse model of diabetes [0.03%]
糖尿病小鼠模型中内皮细胞源性含微小核糖核酸的细胞外囊泡与糖尿病视网膜病变的关系
Meili Wu,Haoyuan Zhou,Tianyi Zong et al.
Meili Wu et al.
Diabetic retinopathy (DR) is a leading cause of visual impairment and blindness in industrialized countries, resulting from diabetes mellitus. Prostaglandin E2 (PGE2), synthesized by cyclooxygenases, contributes to inflammation and apoptosi...