PstS1-loaded exosomes promote Mycobacterium tuberculosis infection via miR-122-mediated PI3K/AKT/mTOR activation and autophagy suppression [0.03%]
JiPing Yang,Wei Qiu,MeiZhen Xu et al.
JiPing Yang et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a chronic respiratory infectious disease. With the continuous increase in new cases, TB has become the second leading infectious disease worldwide, posing a significant chall...
Ex vivo engineering of neural tissue structure and growth using sequential 2D and 3D solid scaffolds [0.03%]
Orly E Weiss,Danny Baranes
Orly E Weiss
Brain injury disrupts tissue integrity, creating wounds with complex boundaries that hinder effective repair. Regeneration and reconnection require guiding deformed tissue along proper growth pathways. Pre-engineered scaffold implants made ...
Corydaline overcomes doxorubicin resistance in oral cancer by activating the p53-Bax-caspase axis and inhibiting MMP-driven invasion: an in vitro, in vivo, and in silico study [0.03%]
Siwei Zhou,Xin Fu,Xu Wang
Siwei Zhou
Corydaline (COR), a natural isoquinoline alkaloid, was evaluated for its anticancer potential against doxorubicin-resistant Cal27 (Dox-Cal27) oral squamous carcinoma cells. Cells treated with increasing concentrations of COR (0-5 µM) were ...
Characterisation of Lates calcarifer primary myoblast proliferation and differentiation from direct cell isolation [0.03%]
Angela Trace,Miriam Wankell,Craig McFarlane et al.
Angela Trace et al.
Cell type characterisation is pivotal for scientific research and discovery. In the literature, multiple fish cell types have been investigated. Nonetheless, primary myoblasts from barramundi (Lates calcarifer) remain poorly characterised, ...
miR-135a-5p exerts tumor-suppressive effects in 769P renal carcinoma cells through the TFAP2A/KRT8 signaling axis [0.03%]
Delong Xie,Jizhe Zhou,Yueyue Guo et al.
Delong Xie et al.
The oncogenic roles of microRNAs have been extensively documented across various cancer types. In the present study, we aimed to investigate the functional impact of miR-135a-5p on the clear cell renal cell carcinoma (ccRCC) cell line 769P....
Isoliquiritin alleviates sepsis-induced intestinal barrier dysfunction in mice potentially by promoting autophagy [0.03%]
Qian Ye,Lingxuan Zhang,Xiuzhen Wang et al.
Qian Ye et al.
Intestinal barrier function protection is essential to ameliorate sepsis. Isoliquiritin (ILQ) is a natural compound with broad biological activities. However, whether ILQ attenuates sepsis-induced intestinal damage remains unclear. An LPS-i...
The effects of omentin on estradiol and progesterone release in human granulosa cell culture [0.03%]
Pınar Tarıkahya,Burcu Baba,Leyla Özer et al.
Pınar Tarıkahya et al.
Adipokines serve as a link between energy metabolism and reproduction, helping to explain infertility related to polycystic ovary syndrome (PCOS). Granulosa cells are known to produce adipokines such as omentin; however, research on the pot...
Establishment of a novel immortalized cell line derived from porcine plasmacytoid dendritic cells [0.03%]
Shunichi Suzuki,Takato Takenouchi,Hirohide Uenishi
Shunichi Suzuki
Pro-myogenic and anti-atrophic effects of Padina arborescens extract through Akt/mTOR signaling in dexamethasone-induced C2C12 cells and zebrafish model [0.03%]
Padina arborescens提取物通过Akt/mTOR信号通路在地塞米松诱导的C2C12细胞和斑马鱼模型中产生促肌源性和抗萎缩效应
Kyeong Min Lee,Wook-Chul Kim,Yun-Su Lee et al.
Kyeong Min Lee et al.
Muscle atrophy, which is characterized by the loss and dysfunction of skeletal muscle proteins, is a major degenerative condition that is associated with aging and glucocorticoid therapy. Marine-derived compounds, particularly polyphenols, ...