KLF5 drives granulosa cell apoptosis and inflammatory injury in polycystic ovary syndrome via transcriptional activation of TXNIP [0.03%]
KLF5通过转录激活TXNIP驱动多囊卵巢综合征颗粒细胞凋亡和炎症损伤
Ying Wang,Jiahui Liu,Yiqun Jiang et al.
Ying Wang et al.
Polycystic ovary syndrome (PCOS), a common endocrine disorder affecting over 10% of women, is characterized by hyperandrogenism and ovarian dysfunction. While linked to chronic inflammation and granulosa cell apoptosis, its molecular mechan...
M2 macrophages alleviate podocyte apoptosis induced by supernatant of glomerular mesangial cells with aIgA1 via targeting UCHL1 [0.03%]
M2型巨噬细胞通过靶向UCHL1缓解系膜细胞培养上清诱导的足细胞凋亡
Yuanjie Lin,Bingqing Liu,Zhengjie Wang et al.
Yuanjie Lin et al.
Immunoglobulin A (IgA) nephropathy (IgAN) is characterized by the deposition of IgA1 in the glomerular mesangium, which induces secondary glomerular and tubulointerstitial inflammation and subsequently leads to podocyte apoptosis and fibros...
ARP2/3 protein complex regulates myoblast proliferation, morphology, migration, and fusion during embryonic chick skeletal myogenesis [0.03%]
肌节蛋白复合体调节鸡胚骨骼肌发生过程中肌管细胞的增殖、形态、迁移及融合等功能
Kayo Moreira Bagri,Paloma de Carvalho Vieira,Manoel Luis Costa et al.
Kayo Moreira Bagri et al.
ARP2/3 is a seven-subunit protein complex involved in the formation of actin filament branching, which is essential for the formation of membrane protrusions, cell migration, and establishment of cell polarity. Among these functions, ARP2/3...
Comparative effect of goat and fetal bovine serum on goat muscle stem cell proliferation in vitro [0.03%]
胎牛血清和山羊血清对山羊肌干细胞体外增殖效果的影响比较研究
Nungnuch Saipin,Sasipat Teerawongsuwan,Natthima Suwan et al.
Nungnuch Saipin et al.
Culturing stem cells in species-specific serum ensures physiological relevance, reduces variability, and supports safer clinical use, highlighting the urgent need to develop reliable, species-matched systems for research and therapy. To add...
MOF promotes cisplatin resistance in lung cancer cells by enhancing WSTF acetylation [0.03%]
金属有机框架通过增强WSTF乙酰化促进肺癌细胞对顺铂的耐药性
Qian Sui,Dongsheng Lin,Fang Huang et al.
Qian Sui et al.
Cisplatin-based chemotherapy is the first-line treatment for lung cancer. However, cisplatin resistance (CR) remains a major challenge, leading to treatment failure. A key driver of CR is enhanced DNA damage repair. Although males absent on...
Co-cultured adipocytes alter the expression of genes involved in extracellular matrix remodeling and metabolic adaptation in muscle cells [0.03%]
共培养的脂肪细胞改变了肌肉细胞中参与细胞外基质重塑和代谢适应的基因的表达
Koichi Ojima,Susumu Muroya,Mika Oe et al.
Koichi Ojima et al.
Skeletal muscle tissue consists of not only myofibers, i.e., muscle cells, but also intramuscular adipocytes. Our previous study demonstrated that adipocytes produce secretory factors during differentiation, leading us to hypothesize that s...
In vitro replication efficiency of tilapia parvovirus (TiPV) using different fish cell lines [0.03%]
不同鱼类细胞系中 tilapia 小 DNA 病毒的复制效率研究
Gani Taju,Seepoo Abdul Majeed,Mohamed Jaffer Abdul Wazith et al.
Gani Taju et al.
Bergapten protects chondrocytes against sodium nitroprusside-induced dedifferentiation and apoptosis through NF-κB and p38 signaling pathway [0.03%]
bergapten通过NF-κB和p38信号途径保护软骨细胞免受硝普钠引起的去分化和凋亡的影响
Rok Su Shim,Young Seok Eom,Song Ja Kim
Rok Su Shim
Bergapten (BG), a furanocoumarin compound, has demonstrated diverse pharmacological properties, including the reduction of oxidative stress and inflammation in osteoarthritic chondrocytes. However, the mechanisms underlying BG's effects on ...
Growth hormone therapy promotes bone growth in idiopathic short stature children by activating the IGF-1 pathway via IGFBP2-mediated inhibition of THBS1 [0.03%]
生长激素通过IGFBP2介导的THBS1抑制活化IGF-1途径促进特发性身材矮小儿童骨增长
Haiyan Liu,Qin Zhao
Haiyan Liu
The molecular mechanisms underlying growth hormone (GH) therapy in children with idiopathic short stature (ISS) remain incompletely understood. This study investigated how GH promotes bone growth in children with ISS, focusing on insulin-li...
Isolation of coelomocyte from sea urchin Echinometra mathaei: optimization of culture condition [0.03%]
海胆Mathaei Coelomocyte的分离培养条件优化研究
Fatemeh Piryaei,Pargol Ghavam Mostafavi,Razieh Dalirfardouei et al.
Fatemeh Piryaei et al.
Rapid growth of the aquaculture industry is hampered by infectious diseases in marine invertebrates, causing economic losses. Marine invertebrate cell cultures offer tools to evaluate biological properties and cellular responses in differen...