ATF4 regulates PI3K/AKT signaling axis to promote angiogenesis after myocardial infarction [0.03%]
ATF4通过调节PI3K/AKT信号轴促进心肌梗死后血管生成
Pingping He,Weirong Zeng,Jiao Li et al.
Pingping He et al.
Effective neovascularization is critical for tissue repair and the enhancement of cardiac function following myocardial infarction (MI). However, the hypoxic microenvironment post-MI significantly impedes neovascular formation. Although ATF...
ALDH4A1 knockdown inhibits in vitro atherosclerosis model by modulating Trim28-mediated P53 ubiquitination to suppress ferroptosis of vascular endothelial cells [0.03%]
醛脱氢酶4家族成员A1通过调节Trim28介导的P53泛素化抑制血管内皮细胞铁死亡从而抑制体外动脉粥样硬化模型形成
Xiaoyong Xu,Xiaorong Xu,Wangzhuo Zhou et al.
Xiaoyong Xu et al.
Atherosclerosis (AS) is a primary contributor to cardiovascular disease (CVD), resulting in high mortality. Ferroptosis, triggered by lipid peroxidation, contribute to AS development. This study aimed to explore the regulatory relationships...
Lactiplantibacillus plantarum promotes lactoferrin synthesis and secretion in bovine mammary epithelial cells through STAT3 and AP-1 transcription factor pathways [0.03%]
植物乳杆菌通过信号转导和转录激活蛋白3及活化蛋白1途径促进牛乳腺上皮细胞溶菌酶合成与分泌
Jinyu Zhou,Shuai Lian,Zijian Geng et al.
Jinyu Zhou et al.
Probiotics can support the immune function of dairy cows and contribute to the synthesis of milk components in mammary gland tissue. Bovine lactoferrin (bLF) possesses immune-regulating and nutritional properties; however, the impact of pro...
KHDRBS3-mediated upregulation of circ_0024107 in gastric cancer cells and GC-MSCs synergistically drives gastric cancer cell migration and invasion [0.03%]
KHDRBS3调控胃癌细胞及GC-MSCs中共表达circ_0024107协同促进胃癌细胞迁移侵袭
Feng Huang,Lin Wang,Xiang Wang et al.
Feng Huang et al.
Gastric cancer is a significant global health concern due to its high morbidity and mortality. Gastric cancer-associated mesenchymal stem cells (GC-MSCs) significantly contribute to its progression, with circ_0024107 being notably elevated ...
Therapeutic potential of miR-10a overexpressing mesenchymal stem cell-derived extracellular vesicles in modulating inflammation in collagen-induced arthritis [0.03%]
miR-10a过表达间充质干细胞来源的细胞外囊泡在下调胶原诱导性关节炎小鼠炎症反应中的治疗潜力研究
Yaohui Bai,Jian Zhao,Mohammad Abtahi et al.
Yaohui Bai et al.
Rheumatoid arthritis (RA) is a chronic autoimmune condition that leads to joint damage. Mesenchymal stem cells (MSCs) are being recognized as a promising treatment option because of their capacity to modulate immune responses. Their therape...
Optimization of a protocol for the high-yield isolation of active muscle stem cells from bovine skeletal muscle tissue [0.03%]
一种高效分离具有活性的牛骨骼肌间充质干细胞培养体系的研究优化
Jeong Min Lee,Hyun Lee,Ye Rin Jeon et al.
Jeong Min Lee et al.
Beef is primarily made up of skeletal muscle tissue. Therefore, the cultivation of bovine muscle stem cells (MSCs) to provide a consistent supply of muscle cells would enhance the sustainability of the cultured beef industry. Here, we repor...
Embryologist versus AI in embryo selection: agreement and impact on pregnancy rates [0.03%]
胚胎学家与AI在胚胎选择上的意见一致性和对怀孕率的影响
Yael Harir,Rona Halevy Amiran,Yuval Or
Yael Harir
Can artificial intelligence match or even outperform experienced embryologists in embryo selection for IVF transfer? To explore this question, we conducted a retrospective cohort study of 82 IVF cycles comparing embryo selections by an embr...
Nuclear protein 1 protects against neonatal hypoxic-ischemic encephalopathy by inhibiting neuronal ferroptosis by improving iron storage [0.03%]
核蛋白1通过改善铁储存抑制神经元铁死亡从而防治新生儿缺氧缺血性脑病
Xining He,Simeng Wei,Yunsheng Fu et al.
Xining He et al.
Recent studies have highlighted the role of ferroptosis in neuronal damage during neonatal hypoxic-ischemic encephalopathy (HIE). Nuclear protein 1 (NUPR1), a newly identified crucial modulator of ferroptosis, remains unexplored in the cont...
Exploring the effects of roscovitine, serum starvation, and contact inhibition at G0/G1 arrest in northern tiger cat dermal fibroblasts [0.03%]
罗库维汀、饥饿血清和接触抑制在北方虎猫皮肤成纤维细胞G0/G1期停滞的影响研究
João Vitor da Silva Viana,Brenna de Sousa Barbosa,Luanna Lorenna Vieira Rodrigues et al.
João Vitor da Silva Viana et al.
Nuclear reprogramming studies are important tools in conserving wild felids, with efficacy depending on efficient G0/G1 cell cycle arrest methodologies. This study evaluated different culture conditions at G0/G1 arrest and the quality of no...
Establishment of a method to evaluate the dynamics of highly chemotactic THP-1 cells during differentiation into monocyte-M1 macrophage-like cells [0.03%]
建立评估高趋化性的单核细胞衍生的M1型类巨噬细胞分化的动态方法
Shuichiro Okamoto,Kei Miyano,Yasumitsu Nishimura et al.
Shuichiro Okamoto et al.
Differentiation of the human monocytic leukemia cell line THP-1 is widely used to analyze the function of monocyte/macrophage-like cells in vitro. Although chemotaxis, a critical function of monocytes/macrophages enabling tissue accumulatio...