A co-culture system to study the effects of Poly I:C-activated microglia on the differentiation of murine primary neural stem cells [0.03%]
Poly I:C活化的小胶质细胞诱导鼠源性神经干细胞分化共培养系统的建立
Marie Pierre Manitz,Karina Violou,Malin Hedstück et al.
Marie Pierre Manitz et al.
Studies in rodents have shown that systemic inflammation induced by prenatal exposure to the viral mimetic polyinosinic:polycytidylic acid (Poly I:C) triggers maternal immune activation. Cytokines released by the maternal immune system can ...
lncRNA PVT1 regulates chondrocyte proliferation and apoptosis through the glycolysis process mediated by miR-552-3p/PKM2 to promote osteoarthritis [0.03%]
长链非编码RNA PVT1通过miR-552-3p/PKM2介导的糖酵解过程调节软骨细胞增殖和凋亡以促进骨关节炎发展
Demiao Zeng,Bin Li,Longhua Zhang et al.
Demiao Zeng et al.
Osteoarthritis (OA) is a common degenerative joint disease, and cartilage dysfunction is the main cause of OA. Long non-coding RNAs (lncRNAs) have been reported to be involved in the development of OA, but the mechanism of action of lncRNA ...
Overexpression of long non‑coding RNA H19 enhances cell viability and inhibits apoptosis in recurrent spontaneous abortion by targeting the miR-29a-3p/SOCS3 axis [0.03%]
长链非编码RNA H19通过靶向miR-29a-3p/SOCS3轴增强复发性自然流产细胞活力并抑制细胞凋亡的过表达
Zhengli Qian,Keyan Luo,Mingzhe Zhang et al.
Zhengli Qian et al.
Recurrent spontaneous abortion (RSA) represents a substantial challenge in reproductive medicine, attributed to a variety of complex factors, among which aberrations in long non-coding RNAs (lncRNAs) play a crucial role. The present study d...
The active ingredient of Ginkgo biloba extract (quercetin) improved H2O2-induced microglia injury by activating NQO1-PI3K/Akt/mTOR signaling [0.03%]
活性成分鼠李素通过激活NQO1-PI3K/Akt/mTOR信号改善银杏叶提取物内皮细胞H2O2损伤作用
Jingchi Sun,Zhousong Zheng
Jingchi Sun
Activated microglia are considered to be closely related to brain senescence and the pathogenesis of neurodegenerative diseases. Ginkgo biloba extract (GBE) is widely used to treat cognitive impairment and Alzheimer's disease (AD). This stu...
Immunomodulatory properties of mesenchymal stem cells within three-dimensional collagen matrices [0.03%]
三维胶原蛋白基质中的间充质干细胞的免疫调节特性
Yenny Yustisia,Koichi Kato
Yenny Yustisia
Mesenchymal stem cells (MSCs) hold promise for treating inflammatory and immune-related diseases; however, their clinical application is limited by poor survival and function post-transplantation. Collagen hydrogels may support MSC viabilit...
Regulation of LCN-2/PI3K/Akt on TNF-α induced inflammatory response of porcine intramuscular adipocytes [0.03%]
LCN-2/PI3K/Akt调节LCN-2/PI3K/Akt调节TNF-α诱导的猪肌间脂肪细胞炎性反应
Xiaoying Dong,Xiaona Zeng,Yongjian Li et al.
Xiaoying Dong et al.
Lipocalin-2 (LCN-2) has a variety of biological functions and produces various effects on adipocytes, such as promoting cell apoptosis, inhibiting preadipocyte differentiation, and weakening insulin signaling. Tumor necrosis factor-α (TNF-...
S100A8/A9-MCAM signaling promotes gastric cancer cell progression via ERK-c-Jun activation [0.03%]
S100A8/S100A9-MAC-1信号轴通过ERK-c-Jun激活促进胃癌细胞增殖和转移
Youyi Chen,Xu Yang,Rie Kinoshita et al.
Youyi Chen et al.
S100 protein family members S100A8 and S100A9 function primarily as a heterodimer complex (S100A8/A9) in vivo. This complex has been implicated in various cancers, including gastric cancer (GC). Recent studies suggest that these proteins pl...
The ability of the polysaccharide extract Cissus sicyoides L. leaves to maintain normal follicle structure in ovarian tissue culture [0.03%]
卡氏卷须葡萄草多糖提取物维持卵巢组织培养中卵泡结构完整性的能力研究
Camila Maria Araújo de Aguiar,Solano Dantas Martins,Alesandro Silva Ferreira et al.
Camila Maria Araújo de Aguiar et al.
The present study aimed to (1) evaluate the effects of different concentrations of the polysaccharide extract of Cissus sicyoides (PE-Cs) during in vitro culture of preantral follicles included in goat ovarian tissue on (i) follicular morph...
LncRNA TP53TG1 promotes the growth and osteo/dentinogenic differentiation of dental pulp stem cells by activating the Smad3 and JNK1/2 pathway [0.03%]
长链非编码RNA TP53TG1通过激活Smad3和JNK1/2信号通路促进牙髓干细胞的增殖及成骨/牙本质分化
Tingyue Li,Zihan Dai,Zhihua Wang et al.
Tingyue Li et al.
TP53TG1 is a long non-coding RNA related to the TP53 gene, which plays an important role in various biological processes such as tumorigenesis, cell cycle regulation, and DNA damage repair. In recent years, researchers have begun to explore...
Inhibition of cGAS-STING signaling pathway alleviates high glucose-induced mesothelial-mesenchymal transition in human peritoneal mesothelial cell line HMrSV5 [0.03%]
cGAS-STING信号通路的抑制可缓解高糖诱导的人腹膜间皮细胞系HMrSV5的间皮-间质转化
Fuxing Dong,Luli Zheng,Fuyuan Hong
Fuxing Dong
The mesothelial-mesenchymal transition (MMT) of peritoneal mesothelial cells is a critical factor contributing to the progression of peritoneal fibrosis. This study aimed to explore the effect of cGAS-STING signaling pathway on the MMT proc...