ALKBH4 confers ferroptosis resistance and drives tumorigenesis via dysregulation of GPX4 in breast cancer cells [0.03%]
ALKBH4通过调节乳腺癌细胞中的GPX4表达赋予铁死亡抵抗并促进肿瘤发生
Mengyuan Wu,Fanlong Meng,Meiqi Xu et al.
Mengyuan Wu et al.
Breast cancer (BC) remains a predominant source of cancer-related fatalities among women globally. While the AlkB homolog family member ALKBH4 has been implicated in cancer, its role and mechanism in BC are unknown. Its role within BC and i...
Influence of puerarin upon mouse hippocampal neurons involved in corticosterone-induced dysfunction [0.03%]
普鲁士朵对皮质酮所致小鼠海马神经元损伤的保护作用研究
Bo Jiang,Fenyu Fu,Shiqiang Yu et al.
Bo Jiang et al.
Corticosterone (CORT) is a glucocorticoid hormone whose prolonged elevation during stress can generate excessive reactive oxygen species (ROS), leading to hippocampal neuron dysfunction. Puerarin, a natural isoflavone extracted from Puerari...
PstS1-loaded exosomes promote Mycobacterium tuberculosis infection via miR-122-mediated PI3K/AKT/mTOR activation and autophagy suppression [0.03%]
负载PstS1的外泌体通过miR-122介导的PI3K/AKT/mTOR活化和自噬抑制促进结核分枝杆菌感染
JiPing Yang,Wei Qiu,MeiZhen Xu et al.
JiPing Yang et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a chronic respiratory infectious disease. With the continuous increase in new cases, TB has become the second leading infectious disease worldwide, posing a significant chall...
Ex vivo engineering of neural tissue structure and growth using sequential 2D and 3D solid scaffolds [0.03%]
基于二维和三维固体支架的离体工程技术用于神经组织结构及生长发育的研究
Orly E Weiss,Danny Baranes
Orly E Weiss
Brain injury disrupts tissue integrity, creating wounds with complex boundaries that hinder effective repair. Regeneration and reconnection require guiding deformed tissue along proper growth pathways. Pre-engineered scaffold implants made ...
Corydaline overcomes doxorubicin resistance in oral cancer by activating the p53-Bax-caspase axis and inhibiting MMP-driven invasion: an in vitro, in vivo, and in silico study [0.03%]
矛头草内酯通过激活p53-Bax-半胱天冬酶轴并抑制基质金属蛋白酶驱动的侵袭克服多柔比星耐药性：体外、体内和分子对接研究
Siwei Zhou,Xin Fu,Xu Wang
Siwei Zhou
Corydaline (COR), a natural isoquinoline alkaloid, was evaluated for its anticancer potential against doxorubicin-resistant Cal27 (Dox-Cal27) oral squamous carcinoma cells. Cells treated with increasing concentrations of COR (0-5 µM) were ...
Characterisation of Lates calcarifer primary myoblast proliferation and differentiation from direct cell isolation [0.03%]
斑点鲬原代肌细胞的增殖与分化特征研究
Angela Trace,Miriam Wankell,Craig McFarlane et al.
Angela Trace et al.
Cell type characterisation is pivotal for scientific research and discovery. In the literature, multiple fish cell types have been investigated. Nonetheless, primary myoblasts from barramundi (Lates calcarifer) remain poorly characterised, ...
miR-135a-5p exerts tumor-suppressive effects in 769P renal carcinoma cells through the TFAP2A/KRT8 signaling axis [0.03%]
微RNA-135a-5p通过转录因子AP-2α/角蛋白8信号轴在769P肾癌细胞中发挥抑癌作用
Delong Xie,Jizhe Zhou,Yueyue Guo et al.
Delong Xie et al.
The oncogenic roles of microRNAs have been extensively documented across various cancer types. In the present study, we aimed to investigate the functional impact of miR-135a-5p on the clear cell renal cell carcinoma (ccRCC) cell line 769P....
Isoliquiritin alleviates sepsis-induced intestinal barrier dysfunction in mice potentially by promoting autophagy [0.03%]
甘草素通过促进自噬可能改善脓毒症诱导的小鼠肠屏障功能障碍
Qian Ye,Lingxuan Zhang,Xiuzhen Wang et al.
Qian Ye et al.
Intestinal barrier function protection is essential to ameliorate sepsis. Isoliquiritin (ILQ) is a natural compound with broad biological activities. However, whether ILQ attenuates sepsis-induced intestinal damage remains unclear. An LPS-i...
The effects of omentin on estradiol and progesterone release in human granulosa cell culture [0.03%]
omentin对人颗粒细胞雌二醇和孕酮释放的影响
Pınar Tarıkahya,Burcu Baba,Leyla Özer et al.
Pınar Tarıkahya et al.
Adipokines serve as a link between energy metabolism and reproduction, helping to explain infertility related to polycystic ovary syndrome (PCOS). Granulosa cells are known to produce adipokines such as omentin; however, research on the pot...
Establishment of a novel immortalized cell line derived from porcine plasmacytoid dendritic cells [0.03%]
一种新的猪浆细胞样树突状细胞永生化细胞系的建立
Shunichi Suzuki,Takato Takenouchi,Hirohide Uenishi
Shunichi Suzuki