Developmental neurotoxicity study of styrene by inhalation in Crl-CD rats [0.03%]
通过对大鼠吸入苯乙烯的发育神经毒性研究评估苯乙烯的发育神经毒性作用
George Cruzan,Willem D Faber,Keith A Johnson et al.
George Cruzan et al.
This study was conducted to assess potential adverse functional and/or morphological effects of styrene on the neurological system in the F2 offspring following F0 and F1 generation whole-body inhalation exposures. Four groups of male and f...
Two generation reproduction study of styrene by inhalation in Crl-CD rats [0.03%]
大鼠吸入正己烷的两代繁殖试验研究报告
George Cruzan,Willem D Faber,Keith A Johnson et al.
George Cruzan et al.
This study was conducted to evaluate the potential adverse effects of styrene on reproductive capability from whole-body inhalation exposure of F0 and F1 parental animals. Assessments included gonadal function, estrous cyclicity, mating beh...
Secalonic acid D blocks embryonic palatal mesenchymal cell-cycle by altering the activity of CDK2 and the expression of p21 and cyclin E [0.03%]
セカラノン酸Dは、CDK2活性およびp21とサイクリンEの発現を変化させることにより、胎児腭側間葉細胞周期進行を阻害する
V C Dhulipala,K K Maddali,W V Welshons et al.
V C Dhulipala et al.
Background: The mycotoxin, secalonic acid D (SAD), a known animal and potential human cleft palate (CP)-inducing agent, is produced by Pencillium oxalicum in corn. SAD selectively inhibits proliferation of murine embryoni...
Postnatal development of the gastrointestinal system: a species comparison [0.03%]
胃肠道系统的产后发育：一种物种的比较研究
Karen Walthall,Gregg D Cappon,Mark E Hurtt et al.
Karen Walthall et al.
Leah Klemmt,Anthony R Scialli
Leah Klemmt
Three mechanisms have been proposed for exposure of the conceptus to chemicals in semen: access of chemicals to the maternal circulation after absorption from the vagina, direct chemical exposure of the conceptus following transport from th...
Craniofacial and axial skeletal defects induced by the fungicide triadimefon in the mouse [0.03%]
一种杀菌剂处理小鼠诱发颅面和躯干骨骼缺陷
Elena Menegola,Maria Luisa Broccia,Francesca Di Renzo et al.
Elena Menegola et al.
Background: Triadimefon is an antifungal derived from triazole. In in vitro whole-rodent embryo cultures, triazole-derivatives showed specific teratogenic effects at the branchial apparatus. The aim of the present work wa...
Occupational exposures and reproductive health: 2003 Teratology Society Meeting Symposium summary [0.03%]
职业接触与生殖健康：2003年胎胚病学学会会议专题讨论会概述
Barbara Grajewski,Joseph B Coble,Linda M Frazier et al.
Barbara Grajewski et al.
Assuring reproductive health in the workplace challenges researchers, occupational safety and health practitioners, and clinicians. Most chemicals in the workplace have not been evaluated for reproductive toxicity. Although occupational exp...
Evaluation of the gene expression changes induced by 17-alpha-ethynyl estradiol in the immature uterus/ovaries of the rat using high density oligonucleotide arrays [0.03%]
高密度寡核苷酸阵列评价17α-乙烯基雌二醇对大鼠未成熟子宫/卵巢基因表达变化的影响
Jorge M Naciff,Suzanne M Torontali,Gary I Overmann et al.
Jorge M Naciff et al.
Background: In a previous study, we determined the effects of 17-alpha-ethynyl estradiol (EE) on gene expression using microarrays that represented approximately 9,000 genes, which was the state of-the-art. Higher content...
Maternal antioxidant supplementation does not reduce the incidence of phenytoin-induced cleft lip and related malformations in rats [0.03%]
母体抗氧化剂补充不能减少大鼠扑痫酮致兔唇和相关畸形的发病率
Dominique Abela,Andrew M Howe,Diana A Oakes et al.
Dominique Abela et al.
There is considerable evidence that phenytoin-induced birth defects in the rat are a consequence of a period of bradycardia and hypoxia in the embryos. Experiments were designed to test the hypothesis that phenytoin-induced birth defects re...
50-Hz magnetic field (0.1-mT) alters c-fos mRNA expression of early post implantation mouse embryos and serum estradiol levels of gravid mice [0.03%]
50赫兹磁场（0.1毫特）对小鼠早期着床胚胎c-fosmRNA表达及孕鼠血清雌二醇水平的影响
Yijun Shi,Xiuqi Bao,Xiaolin Huo et al.
Yijun Shi et al.
Background: We exposed pregnant mice to magnetic or sham fields for 24 hr/day during Gestation Day (GD) 5.5-8.5 to study the effects of 50-Hz 0.1-mT sinusoidal magnetic fields on early pregnancy in mouse embryos and mice....