Effects of tert-butyl acetate on maternal toxicity and embryo-fetal development in Sprague-Dawley rats [0.03%]
特丁基醋酸对大鼠母体毒性和胎仔发育的影响
Y S Yang,T H Ahn,J C Lee et al.
Y S Yang et al.
This study investigated the potential adverse effects of tert-butyl acetate (TBAc) on maternal toxicity and embryo-fetal development after maternal exposure of pregnant rats from gestational days 6 through 19. TBAc was administered to pregn...
Retinoic acid-mediated differentiation protects against nitrofen-induced apoptosis [0.03%]
视黄酸介导的分化对硝基苯诱导的细胞凋亡具有保护作用
Jeremy T Aidlen,Pradeep P Nazarey,T Bernard Kinane et al.
Jeremy T Aidlen et al.
Background: Nitrofen is a diphenyl ether that induces a spectrum of birth defects subsequent to administration to pregnant rodents, in which the molecular etiology of these defects are poorly characterized. Because previo...
Developmental toxicity and uterotrophic studies with di-2-ethylhexyl terephthalate [0.03%]
关于新致畸试验和二烷基磷酸酯增乳研究中的迪乙基己二铵_terephthalate
Willem D Faber,James A Deyo,Donald G Stump et al.
Willem D Faber et al.
Background: These studies were conducted to evaluate the potential adverse effects of di-2-ethylhexyl terephthalate (DEHT) exposure on in utero development in mice and rats. In addition, a uterotrophic assay for estrogeni...
NTP-CERHR expert panel report on the reproductive and developmental toxicity of hydroxyurea [0.03%]
NTP-CERHR羟脲专题报告：羟脲的生殖和发育毒性
Erica L Liebelt,Sophie J Balk,Willem Faber et al.
Erica L Liebelt et al.
Comparative proteome analysis of the embryo proper and yolk sac membrane of day 11.5 cultured rat embryos [0.03%]
培养大鼠胚胎第11.5天胚体和卵黄囊膜的比较蛋白质组分析
Makoto Usami,Katsuyoshi Mitsunaga,Ken Nakazawa
Makoto Usami
Background: Proteomic analysis of cultured postimplantation rat embryos is expected to be useful for investigation into embryonic development. Here we analyzed protein expression in cultured postimplantation rat embryos b...
Comment on developmental toxicity evaluation on Vorinostat and relationship with HDAC inhibition [0.03%]
关于组蛋白脱乙酰酶抑制剂伏立诺汉发育毒性的评价及其与HDAC抑制作用的关系
Erminio Giavini
Erminio Giavini
Deleterious effects of polynuclear aromatic hydrocarbon on blood vascular system of the rat fetus [0.03%]
多环芳烃对大鼠胎儿血液血管系统不良影响
Mrinal K Sanyal,You-Lan Li
Mrinal K Sanyal
Background: Polynuclear aromatic hydrocarbons (PAH), benzo[alpha]pyrene (B[alpha]P) and 7,12-dimethylbenz[alpha]anthracene (DMBA) are toxic environmental agents distributed widely. The relative deleterious effects of thes...
Refinement of a morphological scoring system for postimplantation rabbit conceptuses [0.03%]
完善兔植入后胚胎的形态评分系统
Edward W Carney,Belen Tornesi,Charles Keller et al.
Edward W Carney et al.
Background: The rabbit is used extensively in developmental toxicity testing, yet basic information on rabbit embryo development is lacking. The goals of this study were to refine a rabbit embryo morphology scoring system...
Identification of drug-induced hyper- or hypoprolactinemia in the female rat based on general and reproductive toxicity study parameters [0.03%]
基于一般和生殖毒性参数识别雌性大鼠药物引起的高泌乳素血症或低泌乳素血症
Sabine Rehm,Dinesh J Stanislaus,Patrick J Wier
Sabine Rehm
Observations associated with drug-induced hyper- or hypoprolactinemia in rat toxicology studies may be similar and include increased ovarian weight due to increased presence of corpora lutea. Hyperprolactinemia may be distinguished if mamma...
Shaunfang Li,Barbara Davis
Shaunfang Li
Interpreting histopathology of the female rodent reproductive tract can be challenging in toxicity studies. However, diagnosis can be relatively uncomplicated with an understanding of the relationship between form and function. We describe ...