Mei Yao,Helen E Ritchie,Patricia D Brown-Woodman
Mei Yao
Background: Goldenseal (Hydrastis canadensis L) is a multi-purpose herb (Hobbs, 1990: Pharm Hist 32:79-82) widely used for its antibiotic properties. It is traditionally contraindicated in pregnancy based on in vivo data ...
NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of amphetamine and methamphetamine [0.03%]
美国国家毒理学计划发育与生殖专家委员会关于安非他命和冰毒的发育毒性和生殖毒性报告
Mari Golub,Lucio Costa,Kevin Crofton et al.
Mari Golub et al.
Investigation of the teratogenic potential of ochratoxin A and B using the FETAX system [0.03%]
应用FETAX系统研究OTA和OTB的致畸性
E O&#x;Brien,A Prietz,Daniel R Dietrich
E O&#x;Brien
Background: Ochratoxin A (OTA) is a mycotoxin produced by certain Aspergillus and Penicillium species. It has been observed to be teratogenic in a number of animal models including rat, mouse, hamster, and chick, with red...
NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of methylphenidate [0.03%]
NTP-CERHR专家小组关于安非他明的生殖和发育毒性的报告
Mari Golub,Lucio Costa,Kevin Crofton et al.
Mari Golub et al.
Neuronal migration is transiently delayed by prenatal exposure to intermittent hypoxia [0.03%]
宫内间歇性低氧暴露延迟神经元迁移
Jennifer L Zechel,Jorge L Gamboa,Allyn G Peterson et al.
Jennifer L Zechel et al.
Background: Neonatal neurodevelopment is influenced by a variety of external factors, although the mechanisms responsible are poorly understood. Prenatal hypoxia, from physiological or chemical sources, can have no discer...
Critical window of male reproductive tract development in rats following gestational exposure to di-n-butyl phthalate [0.03%]
孕期暴露于邻苯二甲酸二正丁酯致大鼠生殖道关键发育窗口期的毒性效应研究
Christina M Carruthers,Paul M D Foster
Christina M Carruthers
Background: Gestational exposure to di-n-butyl phthalate (DBP), a ubiquitous environmental contaminant, has been shown to interfere with the development of the male reproductive tract by acting as an antiandrogen. This st...
Effects of hyperthermia and boric acid on skeletal development in rat embryos [0.03%]
高温及硼酸对大鼠胚胎骨骼发育的影响
Wafa A Harrouk,Kellylynn E Wheeler,Gary L Kimmel et al.
Wafa A Harrouk et al.
Background: The individual effects of boric acid (BA) and hyperthermia on the development of the axial skeleton have been reported previously. Both cause an increased incidence of axial skeletal defects including a decrea...
Microarray analysis of genes in fetal central nervous system after ethylnitrosourea administration [0.03%]
亚硝基脲致胎儿中枢神经系统畸形的基因芯片分析研究
Kei-ichi Katayama,Masaki Ueno,Hirofumi Yamauchi et al.
Kei-ichi Katayama et al.
Background: Ethylnitrosourea (ENU), a monofunctional alkylating agent, induces apoptosis and cell cycle arrest in neuroepithelial cells, neural stem cells in the fetal central nervous system (CNS). These effects occur imm...
Prior exposure to indole-3-carbinol decreases the incidence of specific cyclophosphamide-induced developmental defects in mice [0.03%]
吲哚-3-甲醇的早期暴露可降低小鼠发生特定环磷酰胺致发育缺陷的几率
Melissa M Bailey,Robert D Sawyer,Jeremy E Behling et al.
Melissa M Bailey et al.
Background: Indole-3-carbinol (I3C) is a product of the hydrolysis of glucobrassicin that is found in cruciferous vegetables. I3C can intervene in toxic processes that are mediated by oxidative mechanisms because it posse...
Postnatal development of rat pups after maternal exposure to diethanolamine [0.03%]
母体接触二乙醇胺对大鼠幼仔产后发育的影响
Catherine J Price,Melissa C Marr,Christina B Myers et al.
Catherine J Price et al.
Background: Diethanolamine (DEA), a widely used surfactant, was administered to pregnant mice at the oral LD10 resulting in failure of pups to grow and thrive through postnatal day (PND) 3 [National Toxicology Program, 19...