NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene [0.03%]
美国国家毒物学规划处儿童生殖与环境健康研究计划专家工作组关于苯乙烯生殖和发育毒性的报告
Ulrike Luderer,Thomas F X Collins,George P Daston et al.
Ulrike Luderer et al.
Two generation reproduction study of ethylbenzene by inhalation in Crl-CD rats [0.03%]
以太基苯对大鼠两代生殖毒性吸入染毒试验研究
Willem D Faber,Linda S G Roberts,Donald G Stump et al.
Willem D Faber et al.
Background: This study was conducted to evaluate the potential adverse effects of ethylbenzene (EB) on reproductive capability from whole-body inhalation exposure of F0 and F1 parental animals. ...
Reduction in diabetes-induced craniofacial defects by maternal immune stimulation [0.03%]
母体免疫刺激对糖尿病引起的颅面缺陷的改善作用
Terry C Hrubec,M Renee Prater,Kimberly A Toops et al.
Terry C Hrubec et al.
Background: Maternal diabetes can induce a number of developmental abnormalities in laboratory animals and humans, including facial deformities and defects in neural tube closure. The incidence of birth defects in newborn...
Effects of feed restriction during organogenesis on embryo-fetal development in rabbit [0.03%]
妊娠器官发生期限食对兔胚胎-胎仔发育的影响
G D Cappon,T L Fleeman,R E Chapin et al.
G D Cappon et al.
Background: Appropriate maternal nutrition and body weight gain during pregnancy is well established as a major factor in healthy prenatal development in humans. Given the role of nutrition and body weight gain in normal ...
Effects of prenatal perfluorooctane sulfonate (PFOS) exposure on lung maturation in the perinatal rat [0.03%]
孕鼠暴露全氟辛烷磺酸(PFOS)对子代大鼠胎肺成熟度的影响
R C Grasty,J A Bjork,K B Wallace et al.
R C Grasty et al.
Background: Perfluorooctane sulfonate (PFOS), found widely in wildlife and humans, is environmentally and metabolically stable. Environmental PFOS may be from its use as a surfactant, hydrolysis of perfluorooctanesulfonyl...
K K Terry,L A Chatman,G L Foley et al.
K K Terry et al.
Background: Feed restriction with its resultant body weight loss impacts the rodent estrous cycle; however, the manifestation of these changes in a regulatory study design has not been documented. This study reports the e...
Nicotine-induced embryonic malformations mediated by apoptosis from increasing intracellular calcium and oxidative stress [0.03%]
尼古丁诱导的胚胎畸形通过增加细胞内钙离子和氧化应激诱发的细胞凋亡实现
Zhiyong Zhao,E Albert Reece
Zhiyong Zhao
Background: Tobacco smoking by women during pregnancy increases the risk of congenital birth defects in the infants. Among the smoke products, nicotine is believed to be the major teratogenic factor that perturbs embryoni...
The effects of feed restriction during organogenesis on embryo-fetal development in the rat [0.03%]
妊娠早期食物限制对大鼠胎仔发育影响的研究
T L Fleeman,G D Cappon,R E Chapin et al.
T L Fleeman et al.
Background: Given the role of nutrition and body weight gain in normal development, pharmaceuticals intended to reduce appetite and promote weight loss will generate safety data that may be challenging to interpret. To ai...
Inhibition of histone deacetylase activity on specific embryonic tissues as a new mechanism for teratogenicity [0.03%]
组蛋白去乙酰酶活性特异性抑制胚胎组织作为致畸新机制
Elena Menegola,Francesca Di Renzo,Maria L Broccia et al.
Elena Menegola et al.
Background: the inhibition of histone deacetylase (HDAC) has been reported as an effective mechanism on therapy in neoplastic diseases. Among HDAC inhibitors, Trichostatin A (TSA) and Valproic Acid (VPA) prevent the tumor...
Review on testicular development, structure, function, and regulation in common marmoset [0.03%]
关于常见狨猴睾丸发育、结构、功能及调节的研究综述
Ling-Hong Li,James M Donald,Mari S Golub
Ling-Hong Li
Background: The common marmoset (Callithrix jacchus) is a New World primate that has been used increasingly in toxicological evaluations including testing for testicular toxicity of pharmaceutical and environmental chemic...