Gloria D Jahnke,Catherine J Price,Melissa C Marr et al.
Gloria D Jahnke et al.
Background: Berberine, a plant alkaloid, is found in some herbal teas and health-related products. It is a component of goldenseal, an herbal supplement. Berberine chloride dihydrate (BCD) was evaluated for developmental ...
Amina T Farag,Tarek Abdel-Zaher Karkour,Ahmed El Okazy
Amina T Farag
Background: Chlorothalonil (2,4,5,6-tetrachloroisophthalonitril), the nephrotoxic fungicide, was examined for its potential to produce developmental toxicity in mice after oral administration. ...
Inhibiting matrix metalloproteinases with prinomastat produces abnormalities in fetal growth and development in rats [0.03%]
猫毛蛋白酶抑制剂prinomastat可致大鼠胎仔发育异常
Husam S Younis,Bart A Jessen,Ellen Y Wu et al.
Husam S Younis et al.
Background: Matrix metalloproteinases (MMPs) play key roles in remodeling of the extracellular matrix during embryogenesis and fetal development. The objective of this study was to determine the effects of prinomastat, a ...
Failure of homocysteine to induce neural tube defects in a mouse model [0.03%]
同型半胱氨酸在一个动物模型中不能诱导神经管畸形失败
Gregory D Bennett,Janee Vanwaes,Kristine Moser et al.
Gregory D Bennett et al.
Background: Folate deficiencies have been associated with many adverse congenital abnormalities. It is not clear, however, whether these defects are due to a folate deficiency or to an increase in homocysteine. Homocystei...
Maternal and fetal distribution of a phosphorothioate oligonucleotide in rats after intravenous infusion [0.03%]
静脉注射后磷硫化寡核苷酸在大鼠母体和胎儿内的分布
Nicole V Soucy,Jason P Riley,Michael V Templin et al.
Nicole V Soucy et al.
Background: Fetal uptake of an antisense oligonucleotide was evaluated after intravenous (i.v.) dosing of ISIS 2105, a 20-base phosphorothioate oligonucleotide, in timed-pregnant Sprague-Dawley rats. ...
Monomethylarsonic acid and dimethylarsinic acid: developmental toxicity studies with risk assessment [0.03%]
单甲基砷酸和二甲基砷酸的发育毒性及风险评估研究
Lorraine Irvine,Ivan J Boyer,John M DeSesso
Lorraine Irvine
Background: The toxicity of arsenic compounds is highly dependent on the valence and methylation state of the compound. Although there is extensive published literature on the potential developmental toxicity of inorganic...
Japanese medaka (Oryzias latipes): developmental model for the study of alcohol teratology [0.03%]
斑马鱼(Oryzias latipes)，发育模型在日本医学上的应用——酒精畸形学研究的例子
Xueqing Wang,Erin Williams,Mary L Haasch et al.
Xueqing Wang et al.
Background: Animal models are necessary to investigate the mechanism of alcohol-induced birth defects. We have used Japanese medaka (Oryzias latipes) as a non-mammalian model to elucidate the molecular mechanism(s) of eth...
Neuroembryopathic effect of trichloroacetic acid in rats exposed during organogenesis [0.03%]
三氯乙酸的神经胚胎毒性效应研究
Royana Singh
Royana Singh
Background: Halogenated hydrocarbons such as trichloroacetic acid (TCA) are among the most common water supply contaminants in the world. This study examines the effect of TCA on the developing brain of the Charles Foster...
Environmental tobacco smoke and sudden infant death syndrome: a review [0.03%]
环境烟草烟雾与婴儿猝死综合症的关系综述分析
Margaret A Adgent
Margaret A Adgent
Environmental tobacco smoke (ETS), containing the developmental neurotoxicant, nicotine, is a prevalent component of indoor air pollution. Despite a strong association with active maternal smoking and sudden infant death syndrome (SIDS), in...
Developmental toxicity of orally administered technical dimethoate in rats [0.03%]
口服有效敌敌畏对大鼠的发育毒性作用研究
Amina T Farag,Tarek Abdel-Zaher Karkour,Ahmed El Okazy
Amina T Farag
Background: Dimethoate (O,O-dimethyl-S-(N-methylcarbamoyl-methyl) phosphorodithioate), an organophosphate insecticide, was examined for its potential to produce developmental toxicity in rats after oral administration. ...