NTP-CERHR expert panel report on the reproductive and developmental toxicity of soy formula [0.03%]
美国国家毒理学项目儿童生殖健康与环境报告专家组关于豆基配方奶的生殖和发育毒性报告
Karl K Rozman,Jatinder Bhatia,Antonia M Calafat et al.
Karl K Rozman et al.
Claudio Vismara,Renato Bacchetta,Andrea Di Muzio et al.
Claudio Vismara et al.
Background: Since MYS is a microtubular poison with a reversible activity, Xenopus blastulae were exposed to MYS to verify the eventual drug-related developmental suspension and the reversibility of this effect. ...
Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study [0.03%]
一项嵌套病例对照研究：孕期使用非甾体抗炎药导致先天性畸形的风险
Benjamin Ofori,Driss Oraichi,Lucie Blais et al.
Benjamin Ofori et al.
Background: Many women take non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy but the risks for the infant remain controversial. We carried out a study to quantify the association between those women prescri...
Intrauterine death, fetal malformation, and delayed pregnancy in Ljungan virus-infected mice [0.03%]
Ljunlan病毒感染小鼠的宫内死亡、胎儿畸形和妊娠延迟
Annika Samsioe,Ricardo Feinstein,George Saade et al.
Annika Samsioe et al.
Background: A picornavirus (Ljunganvirus [LV]) has recently been associated with disease during pregnancy in its natural rodent reservoir and in humans. A study of laboratory mice infected under controlled conditions was ...
Exposure of pregnant mice to chromium picolinate results in skeletal defects in their offspring [0.03%]
怀孕小鼠接触氯化吡哆醇会导致其后代出现骨骼缺陷
M M Bailey,J G Boohaker,R D Sawyer et al.
M M Bailey et al.
Background: Chromium(III) picolinate, [Cr(pic)(3)], is a widely marketed dietary supplement. However, Cr(pic)(3) has been associated with oxidative damage to DNA in rats and mutations and DNA fragmentation in cell culture...
Teratology study of derivatives of tetramethylcyclopropyl amide analogues of valproic acid in mice [0.03%]
丙二酸衍生物四甲基环丙胺类似物的致畸试验
Akinobu Okada,Yuko Onishi,Yoshinobu Aoki et al.
Akinobu Okada et al.
Background: Although valproic acid (VPA) is used extensively for treating various kinds of epilepsies, it is well known that it causes neural tube and skeletal defects in both humans and animals. The amide and urea deriva...
Prenatal developmental toxicity evaluation of 2',3'-dideoxyinosine (ddI) and 2',3'-didehydro-3'-deoxythymidine (d4T) co-administered to Swiss Albino (CD-1) mice [0.03%]
2',3'-双脱氧鸟苷与2',3'-双脱氢-3'-双脱氧胸腺嘧啶核苷合用的致畸试验
Catherine J Price,Julia D George,Melissa C Marr et al.
Catherine J Price et al.
Background: In pregnant women, antiretroviral drugs improve maternal health and reduce vertical transmission of human immunodeficiency virus to the infant. However, few nonclinical studies have examined the potential for ...
H2O2 induces abnormal tail flexure in Xenopus embryos: similarities with Paraquat teratogenic effects [0.03%]
双氧水诱导的非洲爪蟾胚胎尾部弯曲异常：与除草剂Paraquat致畸作用的相似性研究
Claudio Vismara,Renato Bacchetta,Andrea Di Muzio et al.
Claudio Vismara et al.
Background: As previously shown, Paraquat (PQ) treatments of Xenopus developing embryos mainly induce a characteristic developmental alteration we named "abnormal tail flexure." PQ oxidative activity has been indicated as...
Claudio Vismara,Andrea Di Muzio,Silvia Tarca et al.
Claudio Vismara et al.
Background: The principal Aflatoxin B(1) (AFB(1)) hydroxylated metabolite excreted in milk is Aflatoxin M(1) (AFM(1)) classified in group 2B by the International Agency for Research on Cancer (IARC). Human exposure to AFM...
Interaction of maternal protein and carbon monoxide on pup mortality in mice: implications for global infant mortality [0.03%]
母体蛋白和一氧化碳对小鼠幼崽死亡率的相互作用及其对全球婴儿死亡率的意义
Jarnail Singh
Jarnail Singh
Background: The United States Surgeon General declared 2005 as the "Year of Healthy Child." To improve the health of all children, we need to start before pregnancy, with their mothers. Unfortunately, protein deficiency i...