Developmental toxic effects of antifungal flusilazole administered by gavage to mice [0.03%]
口服供鼠使用的抗真菌剂氟硅唑的发育毒性效应研究
Amina T Farag,Hala H Ibrahim
Amina T Farag
Background: The developmental toxicity of flusilazole was studied in CD-1 mice after oral administration. Methods: Pregnant mice were g...
NTP-CERHR expert panel report on the reproductive and developmental toxicity of genistein [0.03%]
NTP-CERHR专家小组关于染料木素生殖和发育毒性的报告
Karl K Rozman,Jatinder Bhatia,Antonia M Calafat et al.
Karl K Rozman et al.
Effects of copper deficiency on mouse yolk sac vasculature and expression of angiogenic mediators [0.03%]
铜缺乏对小鼠卵黄囊血管和促血管生成介质表达的影响
Soo Jin Yang,Janet Y Uriu-Adams,Carl L Keen et al.
Soo Jin Yang et al.
Background: Cu deficiency results in embryonic defects and yolk sac (YS) vasculature abnormalities. In diverse model systems, Cu treatment modulates angiogenesis, perhaps by influencing the activity of angiogenic mediator...
Postnatal growth and morphological development of the brain: a species comparison [0.03%]
产后脑生长和形态发育的种属差异比较研究
Rebecca E Watson,John M Desesso,Mark E Hurtt et al.
Rebecca E Watson et al.
The objective of this report is to summarize the available literature regarding the postnatal growth and morphological development of the brain and compare the timelines for these events between humans and experimental species. While not th...
Mari S Golub,Farla L Kaufman,Marlissa A Campbell et al.
Mari S Golub et al.
Background: A variety of progestational agents have been used therapeutically and evaluated for adverse effects over the last 50 years. However, progesterone itself has come into use as a therapeutic agent only recently w...
PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells [0.03%]
血小板源性生长因子C调控增殖并通过视黄酸下调腭突间充质细胞中的表达
Jing Han,Ying Xiao,Jiuxiang Lin et al.
Jing Han et al.
Background: Platelet-derived growth factor C (PDGF-C) was recently identified as a member of the PDGF ligand family. Some observation suggests that PDGF-C could play an important role in palatogenesis highlighted by the P...
Artesunate-induced depletion of embryonic erythroblasts precedes embryolethality and teratogenicity in vivo [0.03%]
体内青蒿琥酯诱导胚胎血红细胞耗竭先于胚胎致死和致畸现象发生
Tacey E K White,Paul B Bushdid,Sandra Ritter et al.
Tacey E K White et al.
Background: Artesunate (ART), an artemisinin antimalarial, is embryolethal and teratogenic in rats, with the most sensitive days being 10 and 11 postcoitum (pc), respectively (Clark et al.: Birth Defects Res B 71:380-394,...
Developmental immunotoxicity investigations in the SD rat following pre- and post-natal exposure to cyclosporin [0.03%]
环孢菌素大鼠发育免疫毒性研究
Paul C Barrow,Françoise Horand,Guillaume Ravel
Paul C Barrow
Background: The development and function of the immune system was assessed in juvenile SD rats following pre- or post-natal exposure to cyclosporin. The main objective was to assess the feasibility of the methods availabl...
Developmental toxicity studies in Crl:CD (SD) rats following inhalation exposure to trichloroethylene and perchloroethylene [0.03%]
三氯乙烯和全氯乙烷吸入暴露对Crl:CD（SD）大鼠发育毒性研究
E W Carney,B A Thorsrud,P H Dugard et al.
E W Carney et al.
The potential for trichloroethylene (TCE) and perchloroethylene (PERC) to induce developmental toxicity was investigated in Crl:CD (SD) rats whole-body exposed to target concentrations of 0, 50, 150 or 600 ppm TCE or 0, 75, 250 or 600 ppm P...
HGPRT mutation induction by N-ethyl-N-nitrosourea as measured by 6-thioguanine resistance is higher in male than in female Syrian hamster fetuses [0.03%]
N-乙基-N-亚硝基尿素诱发的大鼠胎儿羟蝶呤鸟嘌呤核糖转移酶突变的性别差异性
Paul J Donovan,George T Smith,Lee F Dove et al.
Paul J Donovan et al.
Background: The consequences of mutations in embryonic and fetal cells are serious and contribute to high prenatal sensitivity to mutagenic agents. An understanding of the factors that influence the yield of such mutation...