The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies [0.03%]
小鼠动情周期：阴道涂片细胞学特征及其在毒理学研究中的应用
Jerome M Goldman,Ashley S Murr,Ralph L Cooper
Jerome M Goldman
While an evaluation of the estrous cycle in laboratory rodents can be a useful measure of the integrity of the hypothalamic-pituitary-ovarian reproductive axis, it can also serve as a way of insuring that animals exhibiting abnormal cycling...
Two-generation reproduction study of di-2-ethylhexyl terephthalate in Crl:CD rats [0.03%]
迪苯二甲酸二(2-乙基己)酯的两代生殖毒性研究
Willem D Faber,James A Deyo,Donald G Stump et al.
Willem D Faber et al.
Background: This study was conducted to evaluate the potential adverse effects of di-2-ethylhexyl terephthalate (DEHT) on reproductive capability from exposure of F(0) and F(1) parental animals. ...
Development of an animal model for ovotoxicity using 4-vinylcyclohexene: a case study [0.03%]
建立四乙烯环己烯诱导的动物卵毒性模型并进行机制研究——以小鼠为例
Patricia B Hoyer,I Glenn Sipes
Patricia B Hoyer
Background: The occupational chemical 4-vinylcyclohexene (VCH) has been shown to cause destruction of small pre-antral follicles in ovaries of mice. Further, its monoepoxide metabolites, 1,2-VCH epoxide, 7,8-VCH epoxide, ...
Spontaneous lesions in the reproductive tract and mammary gland of female non-human primates [0.03%]
非人灵长类动物生殖道和乳腺的自发性损伤
Timothy K Cooper,Kathleen L Gabrielson
Timothy K Cooper
Because of their close phylogenic relationship with humans, the use of non-human primates (NHP) as experimental subjects has a long history in biomedical research. Although research topics have shifted focus and species used have changed, N...
Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague-Dawley rats and Dutch Belted rabbits [0.03%]
评估组蛋白脱乙酰酶抑制剂伏立诺他在Sprague-Dawley大鼠和Dutch Belted兔中的发育毒性
L David Wise,Katie J Turner,Janet S Kerr
L David Wise
Background: The developmental toxicity potential of vorinostat (suberoylanilide hydroxamic acid [SAHA], ZOLINZA), a potent inhibitor of histone deacetylase (HDAC), was assessed in Sprague-Dawley rats and Dutch Belted rabb...
Differential metabolism of benzo[alpha]pyrene in vitro by human placental tissues exposed to active maternal cigarette smoke [0.03%]
人胎盘组织对吸烟母亲香烟中苯并[a]芘的不同代谢作用
Mrinal K Sanyal,You Lan Li
Mrinal K Sanyal
Objectives: Generation of different metabolites and DNA-adduct(s) of metabolites of benzo[alpha]pyrene (B[alpha]P) in vitro by placental tissues (microsomes) of mothers who actively smoked cigarettes (tobacco) and those w...
Production of axial skeletal malformations with the nitric oxide synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in the mouse [0.03%]
用一氧化氮合成酶抑制剂NG-硝基-L-精氨酸甲酯(L-NAME)诱导小鼠发生轴旁骨骼畸形
Gian Mario Tiboni,Francesca Marotta,Lisa Barbacane
Gian Mario Tiboni
Background: To test whether the differentiating embryo is susceptible to the teratogenic effects of the nitric oxide (NO) synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME). ...
Inhalation developmental neurotoxicity study of ethylbenzene in Crl-CD rats [0.03%]
Crl株系Sprague-Dawley大鼠正己烷吸入发育神经毒性试验研究报告
Willem D Faber,Linda S G Roberts,Donald G Stump et al.
Willem D Faber et al.
Background: This study was conducted to evaluate the potential adverse effects of whole-body inhalation exposure of F0 and F1 parental animals from a 2-generation reproduction study of ethylbenzene on nervous system funct...
Antifungal triazole derivative triadimefon induces ectopic maxillary cartilage by altering the morphogenesis of the first branchial arch [0.03%]
三唑类抗真菌衍生物丙环唑通过改变第一咽弓的形态发生诱导上颌软骨异位形成
Francesca Di Renzo,Maria L Broccia,Erminio Giavini et al.
Francesca Di Renzo et al.
Background: The triazole derivative, triadimefon (FON), induces branchial arch abnormalities in post-implantation rat embryos cultured in vitro, and cranio-facial malformations in mouse fetuses. Ectopic maxillary cartilag...
First trimester exposure to paroxetine and risk of cardiac malformations in infants: the importance of dosage [0.03%]
孕期早期接触帕罗西汀与婴儿心脏畸形风险的关系：剂量的重要性
Anick Bérard,Elodie Ramos,Evelyne Rey et al.
Anick Bérard et al.
Background: Conflicting findings with regard to the teratogenic risks of first trimester use of paroxetine have prompted the FDA, Health Canada, and the manufacturer of the drug to issue warnings against its use during pr...