Kai Xiao,Li Wang,Yuqing Liu et al.
Kai Xiao et al.
Background: Aconitum is widely used in traditional medicine for its anti-inflammatory, analgesic, and cardiotonic properties. Knowledge is limited, however, on its effects on embryonic development. ...
Mildred S Christian,Oscar L Laskin,Valerie Sharper et al.
Mildred S Christian et al.
Background: Lenalidomide, a thalidomide analog, is indicated for treatment of patients with deletion-5q myelodysplastic syndromes or multiple myeloma. NZW rabbits were used because of sensitivity to thalidomide's teratoge...
Estrous cycle-dependent histology and review of sex steroid receptor expression in dog reproductive tissues and mammary gland and associated hormone levels [0.03%]
与性激素周期依赖性组织学及犬生殖道和乳腺性别甾体受体表达相关的激素水平及其综述
Sabine Rehm,Dinesh J Stanislaus,Ann M Williams
Sabine Rehm
This report describes normal histology of tissues from immature female dogs and sequential microscopic changes that occur during different stages of the estrous cycle in ovary, uterus, vagina and mammary glands. These observations are assoc...
Histologic changes in ovary, uterus, vagina, and mammary gland of mature beagle dogs treated with the SERM idoxifene [0.03%]
成熟比格犬给予选择性雌激素受体调节剂依曲昔酚后的卵巢、子宫、阴道和乳腺的组织学改变
Sabine Rehm,Henk A Solleveld,Samm T Portelli et al.
Sabine Rehm et al.
Background: Idoxifene is a selective estrogen receptor modulator similar to tamoxifen but is no longer in pharmaceutical development due to adverse genitourinary effects in the clinic. Histologic observations of the repro...
High-throughput staining for the evaluation of fetal skeletal development in rats and rabbits [0.03%]
高通量染色技术在评估大鼠和家兔胎儿骨骼发育中的应用
Brian G Redfern,L David Wise
Brian G Redfern
Typical developmental toxicity studies require the assessment of fetal skeletal development. Regulatory guidelines require the assessment of bone ossification and indicate preferences for an assessment of both ossified bone as well as carti...
Ralph L Cooper,Susan C Laws,Parikshit C Das et al.
Ralph L Cooper et al.
Atrazine, a chlorotriazine herbicide, is used to control annual grasses and broadleaf weeds. In this review, we summarize our laboratory's work evaluating the neuroendocrine toxicity of atrazine (and related chlorotriazines) from an histori...
Assessing the mammary gland of nonhuman primates: effects of endogenous hormones and exogenous hormonal agents and growth factors [0.03%]
非人灵长类乳fang的评估：内源性激素及外源性激素和生长因子的作用
J Mark Cline
J Mark Cline
This review provides a summary of the normal biology, development, and morphology of the breast in nonhuman primates (macaques), and of the major published work addressing hormonally-induced changes in the breast of these animals. The mamma...
Evaluation of aflatoxin B1 embryotoxicity using the frog embryo teratogenesis assay-Xenopus and bio-activation with microsome activation systems [0.03%]
采用WTO毒性胚胎试验和微粒体活化系统评价黄曲霉素B1的致胚胎毒作用
Claudio Vismara,Francesca Caloni
Claudio Vismara
Background: Aflatoxins are a group of mycotoxins produced by Aspergillus, A. flavus, and A. parasiticus. Aflatoxin B1 (AFB1) should be a strong teratogen in hamsters, but its effect in rats is equivocal and extremely limi...
An alternative Alcian Blue dye variant for the evaluation of fetal cartilage [0.03%]
一种用于评估胎儿软骨的替代苯胺蓝染料变异型
Brian G Redfern,L David Wise,Stan Spence
Brian G Redfern
Background: The most comprehensive evaluation of vertebrate skeletal development involves the use of Alizarin Red S dye to stain ossified bone and various other dyes to stain cartilage. The dye used most widely to stain f...